OSM and COL4A4

Number of citations of the paper that reports this interaction (PubMedID 11711546)
0

Data Source:
HPRD (in vitro)

		OSM	COL4A4
Description		oncostatin M	collagen type IV alpha 4 chain
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Cytokine Activity Oncostatin-M Receptor Binding Protein Binding Growth Factor Activity	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Molecular Adaptor Activity
	Biological Process	Positive Regulation Of Acute Inflammatory Response Immune Response Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Interleukin-17 Production Positive Regulation Of Peptidyl-serine Phosphorylation Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Hematopoietic Stem Cell Differentiation	Glomerular Basement Membrane Development
Pathways		Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells
Drugs			TRC093
Diseases			Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
GWAS		Coronary artery disease ( 29212778 33020668) Delirium ( 29631748) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233) Myocardial infarction ( 33532862) Nephropathy ( 21399633) Suicidal ideation ( 30145303) Tonsillectomy ( 27941131)	Birth weight ( 31043758) Body mass index ( 25673413 28270201) Coronary artery disease ( 29212778) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Macular thickness ( 30535121) Systolic blood pressure ( 30578418) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532 31630189)
Interacting Genes		14 interacting genes: APP COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 IL6ST LIFR NF2 OSMR S100P TNNT1 ZNF410	13 interacting genes: ANTXR2 CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 MTDH OSM SAA1 SERPINE2 TGFBI
Entrez ID		5008	1286
HPRD ID		01300	00360
Ensembl ID		ENSG00000099985	ENSG00000081052
Uniprot IDs		B5MCX1 P13725	P53420
PDB IDs		1EVS 8V29 8V2A	5NB1 6WKU
Enriched GO Terms of Interacting Partners?		Collagen Type IV Trimer Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Signaling Pathway Collagen Trimer Basement Membrane Extracellular Matrix Structural Constituent Oncostatin-M Receptor Activity Endoplasmic Reticulum Lumen Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Binding Extracellular Matrix Organization Extracellular Structure Organization Enzyme-linked Receptor Protein Signaling Pathway Extracellular Region Extracellular Matrix Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Complex Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Cell Surface Receptor Signaling Pathway Cytokine Binding Growth Factor Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Cytokine Receptor Activity Receptor Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Glomerular Basement Membrane Development Cell Body Transition Metal Ion Binding External Side Of Plasma Membrane Positive Regulation Of Acute Inflammatory Response Integrin Binding Positive Regulation Of Inflammatory Response Signal Transduction Cell Junction Organization Neuromuscular Junction Development Regulation Of Acute Inflammatory Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Cytokine Slow-twitch Skeletal Muscle Fiber Contraction Response To Peptide Synapse Organization Regulation Of Cell Population Proliferation Acetylcholine Receptor Activator Activity Lipoprotein Particle	Extracellular Matrix Extracellular Region Glycosaminoglycan Binding Extracellular Matrix Binding Extracellular Matrix Structural Constituent Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Collagen Binding Extracellular Structure Organization Extracellular Matrix Organization Extracellular Space Basement Membrane Regulation Of Cell Adhesion Heparin Binding Endodermal Cell Differentiation Acute-phase Response Response To Wounding Oncostatin-M Receptor Binding Cerebellar Granular Layer Morphogenesis Mating Plug Formation Seminal Vesicle Epithelium Development Calcium Ion Binding Acute Inflammatory Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Platelet Activation Angiogenesis Dendrite Regeneration Extracellular Vesicle Regulation Of Intracellular Signal Transduction Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Development Calcium-independent Cell-matrix Adhesion Signaling Receptor Binding Regulation Of Protein Phosphorylation Matrilin Complex Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Monoatomic Ion Transport Oncostatin-M-mediated Signaling Pathway Cell Adhesion Regulation Of Mitochondrion Organization Regulation Of Inflammatory Response Cell Migration Regulation Of Phosphorylation Negative Regulation Of Transport
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