NVL and OSGEP

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		NVL	OSGEP
Description		nuclear VCP like	O-sialoglycoprotein endopeptidase
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Membrane	EKC/KEOPS Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Protein-containing Complex Binding Preribosome Binding	Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Metal Ion Binding TRNA N(6)-L-threonylcarbamoyladenine Synthase Activity
	Biological Process	RRNA Processing Positive Regulation Of Protein Binding Positive Regulation Of Telomere Maintenance Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Regulation Of Protein Localization To Nucleolus Telomerase Holoenzyme Complex Assembly	TRNA Threonylcarbamoyladenosine Modification TRNA Modification TRNA Processing
Pathways			tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		HDL cholesterol levels in HIV infection ( 33109212) Major depressive disorder ( 21042317) Mean corpuscular hemoglobin ( 32888494)	Food addiction ( 27106561)
Interacting Genes		12 interacting genes: ADARB1 CRMP1 FBXO7 HSPB1 LINC00839 NDUFAF1 OSGEP RNF10 RNF4 RPL5 TTF2 UBE2I	25 interacting genes: CIAPIN1 CRIP2 EMCN GP1BA HPS6 LAGE3 LENG1 LGALS4 MUC1 NR3C1 NVL OPTC PDE4DIP PKP4 RBM48 REX1BD SF3B3 SHC1 SP110 SPRED1 TNS1 WDR82 WIZ ZNF579 ZNF775
Entrez ID		4931	55644
HPRD ID		03887	10133
Ensembl ID		ENSG00000143748	ENSG00000092094
Uniprot IDs		B4DF43 O15381	Q9NPF4
PDB IDs		2X8A 6RO1	6GWJ
Enriched GO Terms of Interacting Partners?		Hypoglossal Nerve Morphogenesis Negative Regulation Of Protein Kinase C Signaling Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process SUMO Conjugating Enzyme Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Autoubiquitination Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Double-stranded RNA Adenosine Deaminase Activity Cytoplasm Adenosine To Inosine Editing RNA Processing Spinal Cord Ventral Commissure Morphogenesis Facial Nerve Morphogenesis Cytosol Regulation Of Protein Kinase C Signaling Unfolded Protein Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Kinase C Inhibitor Activity Ubiquitin Binding Regulation Of Kinetochore Assembly Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process SUMO Polymer Binding Protein K48-linked Ubiquitination PML Body Cytosolic Ribosome Negative Regulation Of Protein Neddylation RING-like Zinc Finger Domain Binding SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Lewy Body Core EKC/KEOPS Complex TRNA N(6)-L-threonylcarbamoyladenine Synthase Activity TRNA Threonylcarbamoyladenosine Modification TRNA-specific Adenosine Deaminase Activity Dihydropyrimidinase Activity Regulation Of Centromere Complex Assembly Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization To Chromatin
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