NUMA1 and F2RL1

		NUMA1	F2RL1
Description		nuclear mitotic apparatus protein 1	F2R like trypsin receptor 1
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Plasma Membrane Cell Cortex Membrane Lateral Plasma Membrane Nuclear Matrix Dendrite Spindle Pole Centrosome Protein-containing Complex Microtubule Plus-end Microtubule Minus-end Neuronal Cell Body Cortical Microtubule Mitotic Spindle Astral Microtubule Extracellular Exosome Mitotic Spindle Microtubule Bundle Mitotic Spindle Pole Lateral Cell Cortex Cell Cortex Region Cytoplasmic Microtubule Bundle Mitotic Spindle Midzone	Early Endosome Golgi Apparatus Plasma Membrane Membrane Pseudopodium
	Molecular Function	Structural Molecule Activity Protein Binding Microtubule Binding Lipid Binding Tubulin Binding Protein Domain Specific Binding Phosphatidylinositol Binding Protein-containing Complex Binding Microtubule Plus-end Binding Microtubule Minus-end Binding Dynein Complex Binding Disordered Domain Specific Binding	Proteinase-activated Receptor Activity G-protein Alpha-subunit Binding Protease Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding Signaling Receptor Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule Bundle Formation Nucleus Organization Chromosome Segregation Positive Regulation Of BMP Signaling Pathway Astral Microtubule Organization Positive Regulation Of Microtubule Polymerization Positive Regulation Of Intracellular Transport Positive Regulation Of Keratinocyte Differentiation Cell Division Meiotic Cell Cycle Positive Regulation Of Hair Follicle Development Positive Regulation Of Chromosome Segregation Anastral Spindle Assembly Regulation Of Mitotic Spindle Organization Regulation Of Metaphase Plate Congression Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Chromosome Separation Positive Regulation Of Spindle Assembly	T Cell Activation Involved In Immune Response Immune System Process Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Glomerular Filtration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Chemokine Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Rho Protein Signal Transduction Neutrophil Activation Vasodilation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Eosinophil Degranulation Positive Regulation Of GTPase Activity Innate Immune Response Cell-cell Junction Maintenance Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Positive Chemotaxis Defense Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phagocytosis, Engulfment Establishment Of Endothelial Barrier Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Leukocyte Proliferation Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Renin Secretion Into Blood Stream Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Recruitment of NuMA to mitotic centrosomes Mitotic Prophase	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		Antibody level in response to infection ( 25758998) Microalbuminuria ( 31511532) Severe influenza A (H1N1) infection ( 26379185) Urinary albumin-to-creatinine ratio ( 31511532 31630189)	Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171)
Interacting Genes		27 interacting genes: ABRAXAS2 ACTR1A BRAP BRCC3 CCDC57 CDK6 EPB41 EPB41L1 EPB41L2 ERG F2RL1 GMCL1 GNAI1 GPSM2 NCOA6 PIM1 RAD21 RAE1 RNF10 SMC1A SUMO2 TERF1 TERF2 TNKS USP7 YEATS4 YWHAQ	84 interacting genes: ABCC8 ABHD14A ADCY2 ANKRA2 ARL6IP1 ATP2A2 ATP2B1 ATP2C1 BSG CANX CAPN1 CAPN2 CAPNS1 CBL CD63 CD81 CLPTM1 CNN3 COPS5 CRLS1 CTNNA1 CTSG CYFIP2 DNMT3L ELANE ERGIC3 F2 F2R GJB6 GJC2 GPRASP1 HERPUD1 HLA-E HMOX2 HSPA1B ICAM2 JMY KDELR1 KLC1 LMNA MAP1B MORN4 NAT14 NBPF15 NUMA1 OSTC P4HTM PCBD2 PHLDA1 PIGU PLG PPM1J PRNP PRRT2 PRTN3 PSMC3 PTDSS2 QSER1 R3HDM1 RAD17 RGR RTN1 RTN4 SCN1B SDHD SLC12A5 SLC18B1 SLC1A4 SLC31A2 SLC32A1 SLC35A1 SLC39A13 SLC43A2 SLC75A1 ST14 SYNGR2 TMBIM1 TMED1 TMEM161A TMEM62 TMX2 WFS1 YIPF1 YIPF6
Entrez ID		4926	2150
HPRD ID		01236	02960
Ensembl ID		ENSG00000137497	ENSG00000164251
Uniprot IDs		Q14980 Q3SYK8	P55085
PDB IDs		3RO2 5GXW 6HC2 6QJA	5NDD 5NDZ 5NJ6
Enriched GO Terms of Interacting Partners?		Cell Division Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Protein Localization To Cell Cortex Cytoskeleton Regulation Of Cell Cycle Spindle Pole Mitotic Spindle Pole Regulation Of Cell Cycle Process Regulation Of Telomere Capping Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Organelle Organization Positive Regulation Of Protein Localization To Cell Periphery Establishment Of Meiotic Sister Chromatid Cohesion Negative Regulation Of Chromosome Organization Cell Cortex Nucleoplasm Cytoskeleton Organization Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cortical Actin Cytoskeleton Organization Mitotic Spindle Organization Negative Regulation Of Cell Cycle Positive Regulation Of Chromosome Organization Meiotic Cohesin Complex Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex BRISC Complex Regulation Of Mitotic Spindle Organization Positive Regulation Of Metabolic Process Centrosome Cortical Cytoskeleton Organization Regulation Of Organelle Organization Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Nuclear Matrix Mitotic Cohesin Complex Regulation Of Telomere Maintenance Via Telomerase Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Microtubule Cytoskeleton Organization Involved In Mitosis Negative Regulation Of Cell Cycle Process Establishment Of Sister Chromatid Cohesion Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding	Membrane Plasma Membrane Cellular Homeostasis Intracellular Chemical Homeostasis Endoplasmic Reticulum Calpain Complex Endoplasmic Reticulum Tubular Network Formation Endoplasmic Reticulum Membrane Intracellular Monoatomic Cation Homeostasis Synaptic Vesicle Membrane Intracellular Monoatomic Ion Homeostasis Regulation Of Transport Inorganic Ion Homeostasis Endoplasmic Reticulum Tubular Network Membrane Organization Transmembrane Transport P-type Calcium Transporter Activity Calcium-dependent Cysteine-type Endopeptidase Activity Neutrophil-mediated Killing Of Bacterium Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Inorganic Ion Transmembrane Transport Biological Process Involved In Interaction With Symbiont Serine-type Peptidase Activity Intracellular Calcium Ion Homeostasis Inorganic Cation Transmembrane Transport Positive Regulation Of Transport Monoatomic Cation Transmembrane Transport Regulation Of Metal Ion Transport Cytoplasmic Vesicle Endoplasmic Reticulum Membrane Organization Regulation Of Postsynapse Assembly Monoatomic Ion Transmembrane Transport Chemical Homeostasis Dendrite Calcium Ion Homeostasis Serine-type Endopeptidase Activity Acidic Amino Acid Transport Endoplasmic Reticulum Tubular Network Organization Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Negative Regulation Of Apoptotic Signaling Pathway Neutrophil Mediated Immunity Regulation Of Monoatomic Ion Transport Golgi Apparatus Endoplasmic Reticulum Calcium Ion Homeostasis Neutrophil-mediated Killing Of Gram-negative Bacterium Negative Regulation Of Amyloid-beta Formation Monoatomic Cation Transport Positive Regulation Of Blood Coagulation Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Protein Localization
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