ROR1 and STYX

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		ROR1	STYX
Description		receptor tyrosine kinase like orphan receptor 1	serine/threonine/tyrosine interacting protein
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GO Annotations	Cellular Component	Stress Fiber Cytoplasm Plasma Membrane Cell Surface Membrane Axon Cell Projection Receptor Complex Axon Terminus	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Signaling Receptor Activity Wnt Receptor Activity	Pseudophosphatase Activity Protein Binding F-box Domain Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Sensory Perception Of Sound Cell Population Proliferation Astrocyte Development Wnt Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Inner Ear Development Positive Regulation Of NF-kappaB Transcription Factor Activity	Negative Regulation Of Protein Binding Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Regulation Of ERK1 And ERK2 Cascade
Pathways		WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Pancreatic cancer ( 26098869) Severe bacterial meningitis ( 31092817) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Prostate cancer ( 23535732)
Interacting Genes		15 interacting genes: APP DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 ILKAP JUN MFHAS1 PPM1B PPM1F PTN PTPN6 PTPRR STYX	24 interacting genes: AATK CARHSP1 EGFR EPHA2 EPHA3 EPHA7 EPHB6 ERBB2 ERBB3 ERBB4 FBXO7 FBXW7 IGF1R INSR INSRR KDR KIT LMTK2 MAPK1 MUSK PTK7 ROR1 ROR2 TEK
Entrez ID		4919	6815
HPRD ID		03821	10258
Ensembl ID		ENSG00000185483	ENSG00000198252
Uniprot IDs		Q01973	Q8WUJ0
PDB IDs		5Z55 6BA5 6BAN 6TU9 7TNG	2R0B
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Dephosphorylation Dephosphorylation Protein Tyrosine/serine/threonine Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Cation Binding Peptidyl-tyrosine Dephosphorylation Regulation Of Intracellular Signal Transduction Negative Regulation Of MAPK Cascade Regulation Of Epithelial Cell Migration Peptidyl-threonine Dephosphorylation Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of JNK Cascade Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Phosphatase Activity Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Response To Auditory Stimulus Negative Regulation Of Cell Communication Myeloid Leukocyte Activation Molecular Function Activator Activity Regulation Of JNK Cascade Positive Regulation Of Chemotaxis Neuron Projection Regeneration Regulation Of Signal Transduction Microglial Cell Activation Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Leukocyte Activation Involved In Inflammatory Response Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Long-term Synaptic Potentiation Response To Mechanical Stimulus Dendrite Development Phosphate-containing Compound Metabolic Process Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Chemotaxis Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Protein Localization	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Kinase Activity Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway ATP Binding Nucleotide Binding Transferase Activity Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Phosphorylation Protein Phosphorylation Growth Factor Binding ERBB2 Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade Protein Autophosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Insulin Receptor Activity Signal Transduction Ephrin Receptor Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphate Metabolic Process Peptidyl-tyrosine Phosphorylation Animal Organ Development Insulin Receptor Complex Coreceptor Activity Positive Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Basal Plasma Membrane Positive Regulation Of Cell Migration Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Locomotion ERBB Signaling Pathway Regulation Of Phosphorylation Regulation Of Developmental Process Phosphate-containing Compound Metabolic Process Plasma Membrane Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling
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