NPPC and NPR1

Number of citations of the paper that reports this interaction (PubMedID 1660465)
0

Data Source:
BioGRID (pull down)

		NPPC	NPR1
Description		natriuretic peptide C	natriuretic peptide receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule Protein-containing Complex	Plasma Membrane Membrane Receptor Complex ANPR-A Receptor Complex
	Molecular Function	Signaling Receptor Binding Hormone Activity Guanylate Cyclase Activator Activity Hormone Receptor Binding	Nucleotide Binding Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity ATP Binding GTP Binding G Protein-coupled Peptide Receptor Activity Lyase Activity Phosphorus-oxygen Lyase Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding
	Biological Process	Ossification Angiogenesis Ovarian Follicle Development Cumulus Cell Differentiation Response To Hypoxia Blood Vessel Remodeling Response To Ischemia Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation CGMP Biosynthetic Process Protein Folding Intracellular Calcium Ion Homeostasis Receptor Guanylyl Cyclase Signaling Pathway Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Wounding Post-embryonic Development Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Negative Regulation Of Collagen Biosynthetic Process Gastric Emptying Response To Decreased Oxygen Levels Regulation Of Multicellular Organism Growth Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Osteoblast Differentiation Animal Organ Development Oocyte Development Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Chromosome Organization Meiotic Cell Cycle Negative Regulation Of Meiotic Cell Cycle C-di-GMP Signaling Multicellular Organismal Locomotion Response To Oxygen-glucose Deprivation Blood Vessel Diameter Maintenance Bone Growth Negative Regulation Of Oocyte Maturation Meiotic Cell Cycle Process Involved In Oocyte Maturation Cellular Response To Glycoprotein Negative Regulation Of DNA Biosynthetic Process	CGMP Biosynthetic Process Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Body Fluid Secretion Blood Circulation Regulation Of Blood Pressure Cyclic Nucleotide Biosynthetic Process Positive Regulation Of CGMP-mediated Signaling Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Dopamine Metabolic Process Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Cell Proliferation Blood Vessel Diameter Maintenance
Pathways		Physiological factors	Physiological factors
Drugs			Nitroprusside Nitroglycerin Isosorbide dinitrate Amyl Nitrite Erythrityl tetranitrate Nesiritide Ularitide
Diseases
GWAS		Height ( 18391951 19570815 20881960 25282103 25429064) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172)	Mean arterial pressure ( 27618448) Systolic blood pressure ( 27618448)
Interacting Genes		4 interacting genes: MME NPR1 NPR2 NPR3	7 interacting genes: ATF7IP MTDH NPPA NPPB NPPC PRKG1 UBE2D2
Entrez ID		4880	4881
HPRD ID		08975	00165
Ensembl ID		ENSG00000163273	ENSG00000169418
Uniprot IDs		E5LCN7 P23582	A0A140VJE6 P16066
PDB IDs		1JDP	8TG9 8TGA 9BCL 9BCN 9BCO 9BCP 9BCQ 9BCS 9BCV
Enriched GO Terms of Interacting Partners?		Natriuretic Peptide Receptor Activity CGMP Biosynthetic Process Hormone Binding CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Peptide Hormone Binding Cyclic Purine Nucleotide Metabolic Process Guanylate Cyclase Activity Purine Ribonucleotide Biosynthetic Process Positive Regulation Of Urine Volume Receptor Guanylyl Cyclase Signaling Pathway Ribose Phosphate Biosynthetic Process Regulation Of Blood Pressure Purine Nucleotide Biosynthetic Process Nucleotide Biosynthetic Process Phosphorus-oxygen Lyase Activity Regulation Of Urine Volume Purine-containing Compound Biosynthetic Process Peptide Binding Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process G Protein-coupled Peptide Receptor Activity Blood Circulation Purine Nucleotide Metabolic Process Blood Vessel Remodeling Small Molecule Metabolic Process System Process Nucleotide Metabolic Process Carbohydrate Derivative Biosynthetic Process Purine-containing Compound Metabolic Process Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Tissue Remodeling Neuropeptide Processing ANPR-A Receptor Complex Vestibulocochlear Nerve Maturation Renal System Process Carbohydrate Derivative Metabolic Process Oligopeptidase Activity Creatinine Metabolic Process Cumulus Cell Differentiation C-di-GMP Signaling Activation Of Meiosis Involved In Egg Activation Gastric Emptying Lyase Activity Nucleobase-containing Compound Biosynthetic Process Regulation Of Biological Quality	Hormone Receptor Binding CGMP-mediated Signaling Guanylate Cyclase Activator Activity Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Cyclic Purine Nucleotide Metabolic Process Regulation Of Vascular Permeability Vasodilation Vascular Process In Circulatory System Positive Regulation Of CGMP-mediated Signaling Circulatory System Process Cell Growth Involved In Cardiac Muscle Cell Development Hormone Activity Regulation Of CGMP-mediated Signaling Purine Ribonucleotide Biosynthetic Process Cardiac Conduction System Development Bone Growth Ribose Phosphate Biosynthetic Process Purine Nucleotide Biosynthetic Process Negative Regulation Of Systemic Arterial Blood Pressure Nucleotide Biosynthetic Process Protein Folding Purine-containing Compound Biosynthetic Process Protein-containing Complex Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Negative Regulation Of Blood Pressure Organ Growth Ribonucleotide Metabolic Process Intracellular Signaling Cassette Ribose Phosphate Metabolic Process Cardiac Muscle Tissue Development Purine Nucleotide Metabolic Process Developmental Growth Negative Regulation Of Collecting Lymphatic Vessel Constriction Signaling Receptor Binding Diuretic Hormone Activity Nucleotide Metabolic Process Carbohydrate Derivative Biosynthetic Process Neuropeptide Signaling Pathway Neuropeptide Receptor Binding Response To 3-methylcholanthrene Purine-containing Compound Metabolic Process Cumulus Cell Differentiation C-di-GMP Signaling Multicellular Organismal Locomotion
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