NPHP1 and PAK2

Number of citations of the paper that reports this interaction (PubMedID 16374509)
24

Data Source:
HPRD (in vitro)

		NPHP1	PAK2
Description		nephrocystin 1	p21 (RAC1) activated kinase 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Bicellular Tight Junction Cilium Membrane Motile Cilium Photoreceptor Connecting Cilium Cell Projection Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Postsynaptic Density Membrane Nuclear Speck Secretory Granule Perinuclear Region Of Cytoplasm Glutamatergic Synapse
	Molecular Function	Structural Molecule Activity Protein Binding	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Small GTPase Binding Identical Protein Binding Cadherin Binding Protein Serine Kinase Activity
	Biological Process	Signal Transduction Spermatogenesis Visual Behavior Cell Projection Organization Actin Cytoskeleton Organization Cell Differentiation Spermatid Differentiation Retina Development In Camera-type Eye Protein Localization Involved In Establishment Of Planar Polarity Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly	Stimulatory C-type Lectin Receptor Signaling Pathway Cardiac Muscle Hypertrophy Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Starvation Cell Migration Adherens Junction Assembly Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Maturation Dendritic Spine Development Bicellular Tight Junction Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Execution Phase Of Apoptosis Regulation Of Actin Filament Organization Protein Localization To Cell-cell Junction Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Anchoring of the basal body to the plasma membrane	Nef and signal transduction Generation of second messenger molecules Regulation of PAK-2p34 activity by PS-GAP/RHG10 Regulation of activated PAK-2p34 by proteasome mediated degradation Stimulation of the cell death response by PAK-2p34 FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFA-VEGFR2 Pathway Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle
Drugs			Fostamatinib
Diseases		Joubert syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Senior-Loken syndrome
GWAS			Asthma ( 31959851) Atrial fibrillation ( 29892015) Eosinophil count ( 32888494 27863252) Glucose homeostasis traits ( 25524916) Lymphocyte count ( 27863252 32888494) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum eosinophil basophil counts ( 27863252) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) White blood cell count ( 27863252 32888494)
Interacting Genes		18 interacting genes: ADAM15 ARHGAP32 BCAR1 BCL2L11 COX5B FBXO7 FLNA FLNB FLNC INVS KHDRBS1 NPHP3 NPHP4 PAK2 PTK2B TNK2 TUBB UBQLN4	54 interacting genes: ABI1 ABI2 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 CEBPA DOCK2 DSCR9 DST EIF4B EIF4G1 EP300 FYN GRB2 H4C6 HCK LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NPHP1 OGT PACSIN3 PPM1A RAC1 RAF1 RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1
Entrez ID		4867	5062
HPRD ID		09524	05428
Ensembl ID		ENSG00000144061	ENSG00000180370
Uniprot IDs		B4DQY0 C9JNM7 O15259	A8K5M4 Q13177
PDB IDs		1S1N 6O1Q	3PCS
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Anchoring Junction Vascular Endothelial Growth Factor Receptor Signaling Pathway Focal Adhesion Cell Surface Receptor Signaling Pathway Cytosol Cell Projection Cell Cortex Signal Transduction Endothelin Receptor Signaling Pathway Apical Dendrite Integrin-mediated Signaling Pathway Protein Localization To Cell-cell Junction Actin Cytoskeleton SH3 Domain Binding Developmental Process Cytoplasm Regulation Of Apoptotic Process Cytoskeleton Organization Immune System Process Z Disc Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Programmed Cell Death Actin Cytoskeleton Organization Neurotransmitter Receptor Regulator Activity Perinuclear Region Of Cytoplasm Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Actin Filament-based Process Kidney Development BIM-BCL-2 Complex BIM-BCL-xl Complex Grb2-Sos Complex Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Determination Of Stomach Left/right Asymmetry Photoreceptor Cell Maintenance Determination Of Intestine Left/right Asymmetry Negative Regulation Of Wnt Signaling Pathway Ciliary Base Protein Localization To Ciliary Inversin Compartment Protein Kinase Binding Actin Filament Binding Cell-cell Junction Regulation Of Cell-substrate Adhesion Cell Adhesion Positive Regulation Of Cellular Component Biogenesis Regulation Of Signal Transduction	Regulation Of Cellular Component Organization Cytosol Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Regulation Of Vesicle-mediated Transport Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Fc-gamma Receptor Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Cytoplasm Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Enzyme-linked Receptor Protein Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of MAPK Cascade Focal Adhesion Protein Phosphorylation Ephrin Receptor Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Organelle Organization Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Fc Receptor Signaling Pathway Phosphorylation Positive Regulation Of Cytoskeleton Organization Signal Transduction Anchoring Junction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Organelle Organization Cell Surface Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Immune Response-activating Signaling Pathway Actin Cytoskeleton Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Endocytosis Regulation Of Cell Activation Regulation Of Transport Regulation Of Immune System Process Positive Regulation Of Immune System Process Phosphotyrosine Residue Binding Regulation Of Supramolecular Fiber Organization Regulation Of Endocytosis Regulation Of T Cell Activation Ephrin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Supramolecular Fiber Organization Actin Filament-based Process Protein Kinase Activity Lamellipodium
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