NOTCH4 and NFYA

		NOTCH4	NFYA
Description		notch receptor 4	nuclear transcription factor Y subunit alpha
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Membrane	Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Coactivator Activity Notch Binding Calcium Ion Binding Protein Binding Signaling Receptor Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Luteolysis Branching Involved In Blood Vessel Morphogenesis Cell Fate Determination Morphogenesis Of A Branching Structure Epithelial To Mesenchymal Transition Endothelial Cell Morphogenesis Vasculature Development Regulation Of DNA-templated Transcription Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Tissue Development Hemopoiesis Cell Differentiation Mammary Gland Development Endothelial Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development Regulation Of Developmental Process Positive Regulation Of Developmental Process Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Negative regulation of NOTCH4 signaling	PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		A body shape index ( 34021172) Age-related macular degeneration ( 22694956) Aspartate aminotransferase levels ( 29403010) Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Circulating myeloperoxidase levels (serum) ( 23620142) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Colorectal cancer ( 30529582) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Femur bone mineral density x serum urate levels interaction ( 34046847) Food antigen IgG levels ( 24962563) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Iron status biomarkers (iron levels) ( 28334935) Joint mobility (Beighton score) ( 27182965) Longevity ( 30294719) Lung cancer ( 31577861 28604730) Lung cancer in ever smokers ( 28604730) Lupus nephritis in systemic lupus erythematosus ( 24925725) Migraine ( 27322543) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Obesity-related traits ( 23251661) Objective response to lithium treatment in bipolar disorder ( 26503763) Prostate cancer ( 23535732) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 23894747 19571808 30285260) Soluble receptor for advanced glycation end-product levels ( 26083729) Squamous cell lung carcinoma ( 28604730) Systemic lupus erythematosus ( 32771030 21408207) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Type 1 diabetes (age at diagnosis) ( 33179336) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908 24837172) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Mean spheric corpuscular volume ( 32888494) White blood cell count ( 27863252)
Interacting Genes		22 interacting genes: DLL4 EGFL7 ELOC FBXW7 MAML1 MAML2 MAML3 MSH5 NEU1 NFKBIL1 NFYA PBX2 PSEN1 PSEN2 PSMB8 RBPJ SLC27A4 SMAD2 SMAD3 SMAD4 TDP2 WWP2	52 interacting genes: APP APPBP2 ATF6 ATF6B ATXN1 BANP BRCA1 CCNA2 CDC25A CDK2 CDKN1A CEBPA CSNK2A1 DVL3 E2F6 ELF1 EP300 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NEU1 NFYB NFYC NOTCH4 NR5A1 PAPOLG POGZ POU2F1 POU3F2 PWP1 QRICH1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TCAF1 TOPBP1 TP53 UBL5 USF1 USF2 VEZF1 ZC3H10 ZHX1 ZHX2 ZHX3
Entrez ID		4855	4800
HPRD ID		01290	01793
Ensembl ID		ENSG00000204301	ENSG00000001167
Uniprot IDs		A0A1U9X983 Q99466	P23511
PDB IDs		7OR3 7OR5 7OR7	4AWL 6QMP 6QMQ 6QMS 8QU2 8QU3 8QU4
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process SMAD Protein Complex Positive Regulation Of Transcription By RNA Polymerase II Heteromeric SMAD Protein Complex Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regionalization I-SMAD Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Blood Vessel Lumenization Anterior/posterior Pattern Specification Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding MAML1-RBP-Jkappa- ICN1 Complex Activin Responsive Factor Complex SMAD Protein Signal Transduction Paraxial Mesoderm Morphogenesis R-SMAD Binding Regulation Of Notch Signaling Pathway Activin Receptor Signaling Pathway Pattern Specification Process Tissue Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Endoderm Development Positive Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Transcription Regulator Complex Epithelial Tube Morphogenesis Embryonic Morphogenesis Regulation Of Gene Expression Mesoderm Morphogenesis Regulation Of Macromolecule Biosynthetic Process Neuron Fate Commitment Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Primary Metabolic Process Negative Regulation Of Ossification Pericardium Development Aspartic Endopeptidase Activity, Intramembrane Cleaving Negative Regulation Of Macromolecule Biosynthetic Process Ventricular Cardiac Muscle Tissue Morphogenesis	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Primary Metabolic Process Chromatin Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Protein Heterodimerization Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Metabolic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Initiation Transcription Cis-regulatory Region Binding DNA-templated Transcription Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Cellular Senescence Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Metabolic Process ER-nucleus Signaling Pathway
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