CNOT2 and CNOT3

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical)
HPRD (in vivo, two hybrid)

		CNOT2	CNOT3
Description		CCR4-NOT transcription complex subunit 2	CCR4-NOT transcription complex subunit 3
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane CCR4-NOT Complex CCR4-NOT Core Complex	P-body Nucleus Cytoplasm Cytosol CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Transcription Corepressor Binding Transcription Coregulator Activity Poly(A)-specific Ribonuclease Activity Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Translation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Stem Cell Population Maintenance	Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Cold-induced Thermogenesis Regulation Of Stem Cell Population Maintenance
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Diastolic blood pressure ( 27841878) Ovarian cancer ( 30557369) Triglyceride levels ( 32154731)	PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575)
Interacting Genes		27 interacting genes: ARMC5 BCL6 BEX1 CCHCR1 CFAP68 CIMIP1 CNOT1 CNOT3 CNOT8 CSTF2 DDB1 DSCR9 GALNT10 GCSAM GPS1 GPS2 HSF2BP MTFR1L NCOR1 NCOR2 OBI1 PRR35 PSMB4 RACK1 TBX2 TEKT3 ZFHX3	11 interacting genes: CAND1 CAND2 CNOT1 CNOT2 CNOT4 CNOT8 CREBBP ID3 LAIR1 OBI1 RUNX1
Entrez ID		4848	4849
HPRD ID		05367	05368
Ensembl ID		ENSG00000111596	ENSG00000088038
Uniprot IDs		B2RDX7 B3KTL6 F8VUB4 F8VV52 Q9NZN8	O75175
PDB IDs		4C0D 4C0F 5FU6 5FU7	4C0D 4C0G 5FU6 5FU7 9C3H 9C3I
Enriched GO Terms of Interacting Partners?		CCR4-NOT Core Complex CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening Rhythmic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction GTPase Inhibitor Activity Transcription Repressor Complex Poly(A)-specific Ribonuclease Activity RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nuclear Retinoic Acid Receptor Binding Trophectodermal Cell Differentiation Negative Regulation Of Androgen Receptor Signaling Pathway Nucleus P-body Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cellular Senescence Regulation Of B Cell Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process Axonemal A Tubule Inner Sheath Negative Regulation Of MiRNA Transcription Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process MRNA Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of JNK Cascade Cyclin Binding Negative Regulation Of Cardiac Chamber Formation Histone Deacetylase Binding Negative Regulation Of Heart Looping Regulation Of Androgen Receptor Signaling Pathway Regulation Of Brood Size Outer Acrosomal Membrane Adrenal Cortex Development Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process	CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening CCR4-NOT Core Complex Poly(A)-specific Ribonuclease Activity Nuclear-transcribed MRNA Catabolic Process SCF Complex Assembly MRNA Catabolic Process RNA Catabolic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly P-body Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nucleobase-containing Compound Catabolic Process Trophectodermal Cell Differentiation Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Negative Regulation Of Macromolecule Biosynthetic Process TBP-class Protein Binding Negative Regulation Of Biosynthetic Process Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Transcription Corepressor Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression MRNA Metabolic Process Protein Ubiquitination Transcription Coactivator Binding Negative Regulation Of Metabolic Process Cellular Response To Leptomycin B Leptomycin B Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Autoubiquitination Regulation Of Stem Cell Population Maintenance Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
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