NME4 and TRAPPC2B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NME4	TRAPPC2B
Description		NME/NM23 nucleoside diphosphate kinase 4	trafficking protein particle complex subunit 2B
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane	Nucleus Nuclear Outer Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment TRAPP Complex Perinuclear Region Of Cytoplasm TRAPPII Protein Complex TRAPPIII Protein Complex
	Molecular Function	Nucleotide Binding Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding Phospholipid Binding Lipid Binding Kinase Activity Transferase Activity Protein-containing Complex Binding Metal Ion Binding GTPase Binding Phosphatidylglycerol Transfer Activity Mitochondrion-mitochondrion Outer Membrane Tether Activity Cardiolipin Binding	Transcription Corepressor Binding Protein Binding Transcription Regulator Inhibitor Activity
	Biological Process	GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Lipid Transport Nucleoside Metabolic Process Nucleotide Metabolic Process Protein Hexamerization Intermembrane Phospholipid Transfer	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Coating Positive Regulation Of Gene Expression Vesicle-mediated Transport COPII Vesicle Coating Vesicle Tethering
Pathways		Interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS		Body mass index ( 26426971) Red blood cell traits ( 23446634)
Interacting Genes		39 interacting genes: ABI2 AIRIM ARMC7 ATPAF2 C14orf119 CABP2 CABP5 CCDC102B CCDC57 CDKN2D CFAP206 CIB1 CIB3 CIDEB CLNK DTX2 HDAC7 HSF2BP LMO4 LSM8 MKRN3 MLH1 NME1 NME7 NUTF2 NXF1 POLR1C PSMB1 SOCS3 SPG21 SUV39H2 TNS4 TRAPPC2 TRAPPC2B TRIP13 TSSK3 TTC19 UBL5 ZBTB16	19 interacting genes: EPS15L1 INCA1 JOSD2 KCTD1 LSM3 MBD3L1 NICN1 NME4 SLC25A35 SNAPC5 TEPSIN TRAPPC3 TRAPPC5 TRIM42 UQCC2 ZBED1 ZNF438 ZNF655 ZRANB1
Entrez ID		4833	10597
HPRD ID		03489
Ensembl ID		ENSG00000103202	ENSG00000256060
Uniprot IDs		A0A087WVT9 O00746	P0DI82
PDB IDs		1EHW
Enriched GO Terms of Interacting Partners?		Protein Binding Male Meiotic Nuclear Division Male Germ Cell Nucleus UTP Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process 3'-5'-DNA Exonuclease Activity Female Meiosis I CTP Metabolic Process CTP Biosynthetic Process TRAPPII Protein Complex TRAPPIII Protein Complex Meiosis I Cell Cycle Process Nucleoside Diphosphate Kinase Activity TRAPP Complex Meiotic Nuclear Division Filopodium Tip Female Meiotic Nuclear Division	TRAPPII Protein Complex TRAPPIII Protein Complex TRAPP Complex COPII Vesicle Coating Deubiquitinase Activity Vesicle Tethering Intermembrane Phospholipid Transfer Protein Autosumoylation Vesicle Coating TRAPPI Protein Complex Coated Vesicle Membrane
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