NME2 and HERC6

Number of citations of the paper that reports this interaction (PubMedID 18535780)
0

Data Source:
BioGRID (two hybrid)

		NME2	HERC6
Description		NME/NM23 nucleoside diphosphate kinase 2	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
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GO Annotations	Cellular Component	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Focal Adhesion Lamellipodium Secretory Granule Lumen Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Ficolin-1-rich Granule Lumen	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding DNA-binding Transcription Activator Activity DNA Binding Nuclease Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity GDP Binding Identical Protein Binding Metal Ion Binding G-quadruplex DNA Binding	Ubiquitin-protein Transferase Activity Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Cell Adhesion Integrin-mediated Signaling Pathway Nucleotide Metabolic Process Nucleoside Triphosphate Biosynthetic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Keratinocyte Differentiation Regulation Of Epidermis Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II ITP Biosynthetic Process Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of DNA-templated Transcription Initiation	Hematopoietic Progenitor Cell Differentiation Ubiquitin-dependent Protein Catabolic Process Response To Bacterium Protein Ubiquitination
Pathways		Interconversion of nucleotide di- and triphosphates Neutrophil degranulation Azathioprine ADME Ribavirin ADME	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Guanosine-5'-Diphosphate
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Height ( 20881960)	Lean body mass ( 28552196) Metabolite levels ( 22916037) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: BNIPL CEBPA CTBP1 DNM1 GIT2 HERC3 HERC5 HERC6 MOB4 NME3 PPP2CA RAB5A RORA RORB SVIL TBXA2R TERF1 VIM	4 interacting genes: HERC3 HERC4 NME2 UBE2L3
Entrez ID		4831	55008
HPRD ID		01132	13647
Ensembl ID		ENSG00000243678	ENSG00000138642
Uniprot IDs		F6XY72 P22392 Q6FHN3	Q8IVU3
PDB IDs		1NSK 1NUE 3BBB 3BBC 3BBF 7KPF 8PIE 8PYW	5W87
Enriched GO Terms of Interacting Partners?		White Fat Cell Differentiation Regulation Of Vesicle Size GDP Binding FAR/SIN/STRIPAK Complex Synaptic Vesicle Recycling Response To Lipid RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Integrated Stress Response Signaling Transcription Coregulator Binding Clathrin Coat Assembly Involved In Endocytosis Mitochondrial Outer Membrane Fusion Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Transcription Corepressor Binding Cellular Response To Lipid Nuclear Receptor Activity	Ubiquitin-protein Transferase Activity Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation ITP Biosynthetic Process Protein Histidine Kinase Activity Post-translational Protein Modification Macromolecule Catabolic Process ITP Metabolic Process Proteolysis UTP Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process G-quadruplex DNA Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin Protein Ligase Activity Nucleoside Diphosphate Kinase Activity CTP Metabolic Process CTP Biosynthetic Process Protein Modification Process Positive Regulation Of Keratinocyte Differentiation Ubiquitin-like Protein Transferase Activity GTP Metabolic Process Catabolic Process Pyrimidine Ribonucleotide Biosynthetic Process DNA-binding Transcription Activator Activity Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Epidermis Development Pyrimidine Nucleotide Biosynthetic Process Positive Regulation Of Protein Targeting To Mitochondrion Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Keratinocyte Differentiation Protein K11-linked Ubiquitination Pyrimidine-containing Compound Biosynthetic Process Regulation Of Protein Targeting To Mitochondrion
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