NGF and A2M

Number of citations of the paper that reports this interaction (PubMedID 10681572)
0

Data Source:
HPRD (in vitro)

		NGF	A2M
Description		nerve growth factor	alpha-2-macroglobulin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Golgi Lumen Cytosol Synaptic Vesicle Axon Dendrite Endosome Lumen	Extracellular Region Extracellular Space Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Enzyme Inhibitor Activity Signaling Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Lipid Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Peptidase Inhibitor Activity Death Receptor Agonist Activity	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Peptidase Inhibitor Activity Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Peripheral Nervous System Development Circadian Rhythm Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Sensory Perception Of Pain Nerve Development Neuron Projection Development Positive Regulation Of Protein Ubiquitination Nerve Growth Factor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Collateral Sprouting Axon Extension Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Complement Activation, Lectin Pathway Stem Cell Differentiation
Pathways		PLC-gamma1 signalling Signalling to RAS NGF processing NGF processing Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Retrograde neurotrophin signalling Retrograde neurotrophin signalling TRKA activation by NGF TRKA activation by NGF Signalling to p38 via RIT and RIN NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling PI3K/AKT activation PI3K/AKT activation Signalling to STAT3 NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix HDL assembly
Drugs		Clenbuterol RI 624 Polaprezinc Fasinumab Oleandrin	Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Coronary artery disease ( 33020668) Diastolic blood pressure ( 27841878) Dysmenorrheic pain ( 27454463) Dysmenorrheic pain severity ( 29855537) Menstruation quality of life impact (dysmenorrhea) ( 29855537) Migraine ( 27182965 27322543) Migraine without aura ( 27322543) Obstetric antiphospholipid syndrome ( 28424481) Pain medicine use during menstruation ( 29855537) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Red blood cell count ( 32888494) Schizophrenia ( 30285260) Systolic blood pressure ( 27841878)	Refractive error ( 32231278)
Interacting Genes		11 interacting genes: A2M CRYAB ITGA9 ITGB1 LRP1 MMP7 NGFR NTRK1 PLG SORCS3 SORT1	99 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSP90AA1 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SLC6A4 SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS USP40
Entrez ID		4803	2
HPRD ID		08874	00072
Ensembl ID		ENSG00000134259	ENSG00000175899
Uniprot IDs		A0A346FYQ1 P01138	P01023
PDB IDs		1SG1 1WWW 2IFG 4EDW 4EDX 4ZBN 5JZ7 6YW8	1BV8 2P9R 6TAV 7O7L 7O7M 7O7N 7O7O 7O7P 7O7Q 7O7R 7O7S 7VON 7VOO
Enriched GO Terms of Interacting Partners?		Nerve Growth Factor Binding Cell Surface Integrin Alpha9-beta1 Complex Nerve Growth Factor Receptor Activity Neurotrophin Binding Integrin Binding Involved In Cell-matrix Adhesion Cellular Response To Amyloid-beta Synaptic Membrane Cerebellar Climbing Fiber To Purkinje Cell Synapse Modulation Of Chemical Synaptic Transmission Response To Amyloid-beta Signaling Receptor Activity Amyloid-beta Binding Negative Regulation Of Vasoconstriction Enzyme-linked Receptor Protein Signaling Pathway Nerve Growth Factor Signaling Pathway Protease Binding Neurotrophin TRK Receptor Signaling Pathway Apolipoprotein Binding Detection Of Temperature Stimulus Dendritic Spine Response To Temperature Stimulus System Process Integrin Complex Neurotrophin Signaling Pathway Plasma Membrane Myoblast Differentiation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Migration Receptor Complex Regulation Of Cell Motility Regulation Of Locomotion Extracellular Matrix Disassembly Nerve Development Extracellular Matrix Organization Extracellular Structure Organization Vascular Process In Circulatory System Myoblast Fate Specification Learning Or Memory Coreceptor Activity Integrin Alpha7-beta1 Complex Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Antibacterial Peptide Secretion Neurotrophin P75 Receptor Binding Neurotensin Receptor Activity, Non-G Protein-coupled Cell Surface Receptor Signaling Pathway Endosome Membrane Platelet Alpha Granule Lumen	Negative Regulation Of Multicellular Organismal Process Extracellular Exosome Extracellular Space Peptidase Activity Ovulation From Ovarian Follicle Regulation Of Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hydrolase Activity Ovulation Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Blood Coagulation Negative Regulation Of Platelet Activation Regulation Of Hemostasis Extracellular Region Regulation Of Amyloid-beta Clearance Positive Regulation Of Cell Adhesion Smooth Muscle Adaptation Regulation Of Programmed Cell Death Regulation Of Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Positive Regulation Of Amyloid-beta Clearance Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Proteolysis Negative Regulation Of Coagulation Regulation Of Cell Adhesion Regulation Of Biological Quality Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Process Positive Regulation Of Cell Activation Identical Protein Binding Positive Regulation Of Protein Metabolic Process Protein Refolding Positive Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Lymphocyte Activation Regulation Of Transport Melanosome Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Serine-type Endopeptidase Activity Positive Regulation Of Cell Motility Extracellular Matrix Lipoprotein Particle Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process
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