NFIB and FOXL1

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (pull down)

		NFIB	FOXL1
Description		nuclear factor I B	forkhead box L1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Cerebellar Mossy Fiber	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity DNA Binding, Bending Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Tissue Homeostasis Chondrocyte Differentiation Glandular Epithelial Cell Differentiation DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Cell Population Proliferation Response To Wounding Response To Bacterium Glial Cell Differentiation Exit From Mitosis Gene Expression Glial Cell Proliferation Stem Cell Population Maintenance Principal Sensory Nucleus Of Trigeminal Nerve Development Glial Cell Fate Specification Cell Proliferation In Forebrain Anterior Commissure Morphogenesis Neurogenesis Lung Development Forebrain Development Hindbrain Development Regeneration Negative Regulation Of DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Generation Of Neurons Retina Development In Camera-type Eye Club Cell Differentiation Type I Pneumocyte Differentiation Type II Pneumocyte Differentiation Salivary Gland Cavitation Cell Differentiation Involved In Salivary Gland Development Lung Ciliated Cell Differentiation Neural Precursor Cell Proliferation Commissural Neuron Axon Guidance Stem Cell Proliferation Negative Regulation Of MiRNA Transcription Negative Regulation Of Stem Cell Proliferation Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Visceral Mesoderm-endoderm Interaction Involved In Midgut Development Heart Development Anatomical Structure Morphogenesis Regulation Of Wnt Signaling Pathway Cell Differentiation Proteoglycan Biosynthetic Process Peyer's Patch Morphogenesis
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Alcoholic chronic pancreatitis ( 28754779) Alzheimer's disease biomarkers ( 23419831) Ankle injury ( 28957384) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels ( 32203549) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Metastasis at diagnosis in osteosarcoma ( 26084801) Red blood cell count ( 32888494)	Bone mineral density ( 24249740) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Bone properties (heel) ( 24430505) Colorectal cancer ( 25990418) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 33020668) Dentures ( 31235808) Diverticular disease ( 30177863) Femoral neck bone mineral density ( 22504420 29499414) Haemorrhoidal disease ( 33888516) Incident myocardial infarction ( 26950853) Lateral ventricular volume in normal aging ( 30258056) Lumbar spine bone mineral density ( 29499414) Mild to moderate chronic kidney disease ( 31178898) Multiple system atrophy ( 27629089) Nonsyndromic cleft palate ( 31609978) Nose size ( 27182965) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obesity-related traits ( 23251661) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Sepsis in extremely premature infants ( 28283553) Systemic juvenile idiopathic arthritis ( 27927641) Urinary albumin-to-creatinine ratio ( 32600054) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		18 interacting genes: ELK3 ERG ETV7 FLT3 FOS FOXL1 GATA2 GATA3 KLF16 KLF8 LHX2 LHX3 NFIC NFIX NHLH1 RFX1 SFN TBXT	4 interacting genes: BMPR2 NFIA NFIB NFIC
Entrez ID		4781	2300
HPRD ID		09008	07219
Ensembl ID		ENSG00000147862	ENSG00000176678
Uniprot IDs		A0A0A0MRX8 A0A1B0GU97 A0A1B0GVN4 A0A1B0GW37 A0A1B0GWB8 A0A2R8Y7V8 O00712 Q5VW26 Q5VW27 Q5VW28 Q5VW30 Q5W0Y9 U3KQE8	Q12952 Q498Y4
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Cellular Developmental Process Negative Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-templated Transcription DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Coregulator Binding Positive Regulation Of Biosynthetic Process Thyroid-stimulating Hormone-secreting Cell Differentiation Negative Regulation Of Metabolic Process Transcription Coactivator Binding Positive Regulation Of Metabolic Process Positive Regulation Of MiRNA Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Neuron Differentiation Developmental Process	Retina Development In Camera-type Eye Glial Cell Fate Specification DNA Replication Exit From Mitosis Generation Of Neurons Neuron Fate Specification Glial Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process BMP Signaling Pathway Cell Fate Specification Positive Regulation Of Nucleobase-containing Compound Metabolic Process Neural Precursor Cell Proliferation Lung Development DNA-binding Transcription Factor Activity Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Lung Ciliated Cell Differentiation Neurogenesis Cell Population Proliferation DNA Metabolic Process Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Mitotic Cell Cycle Phase Transition Cell Differentiation Involved In Salivary Gland Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Positive Regulation Of Macromolecule Biosynthetic Process Fibrillar Center Cell Cycle Phase Transition Positive Regulation Of Biosynthetic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Activity, Type II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Principal Sensory Nucleus Of Trigeminal Nerve Development Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Lung Blood Pressure Cell Junction Pulmonary Valve Development Tricuspid Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Chromatin Response To Wounding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Club Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process
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