NF1 and DNAJC7

Number of citations of the paper that reports this interaction (PubMedID 8836031)
0

Data Source:
HPRD (in vivo)

		NF1	DNAJC7
Description		neurofibromin 1	DnaJ heat shock protein family (Hsp40) member C7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane Axon Dendrite Presynapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Lipid Binding Phosphatidylethanolamine Binding Phosphatidylcholine Binding	ATPase Activator Activity Protein Binding Heat Shock Protein Binding
	Biological Process	MAPK Cascade Angiogenesis Osteoblast Differentiation Metanephros Development Response To Hypoxia Liver Development Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Leukocyte Migration Protein Import Into Nucleus Apoptotic Process Cell Communication Ras Protein Signal Transduction Neurotransmitter Secretion Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Brain Development Peripheral Nervous System Development Heart Development Skeletal Muscle Tissue Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Visual Learning Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Negative Regulation Of Schwann Cell Proliferation Glial Cell Proliferation Schwann Cell Proliferation Schwann Cell Development Cell Migration Negative Regulation Of Angiogenesis Rac Protein Signal Transduction Spinal Cord Development Amygdala Development Forebrain Astrocyte Development Neural Tube Development Cerebral Cortex Development Myelination In Peripheral Nervous System Actin Cytoskeleton Organization Extracellular Matrix Organization Collagen Fibril Organization Osteoclast Differentiation Adrenal Gland Development Negative Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Mast Cell Apoptotic Process Positive Regulation Of Mast Cell Apoptotic Process Myeloid Cell Apoptotic Process Positive Regulation Of Myeloid Cell Apoptotic Process Cellular Response To Heat Negative Regulation Of Rac Protein Signal Transduction Schwann Cell Migration Wound Healing Regulation Of Cell Population Proliferation Negative Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of MAPK Cascade Pigmentation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Neuron Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Regulation Of Bone Resorption Negative Regulation Of Osteoclast Differentiation Regulation Of Glial Cell Differentiation Regulation Of Angiogenesis Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotransmitter Secretion Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Sympathetic Nervous System Development Camera-type Eye Morphogenesis Astrocyte Differentiation Oligodendrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Smooth Muscle Tissue Development Hair Follicle Maturation Artery Morphogenesis Forebrain Morphogenesis Regulation Of Developmental Process Cognition Neuron Apoptotic Process Negative Regulation Of Glial Cell Proliferation Long-term Synaptic Potentiation Gamma-aminobutyric Acid Secretion, Neurotransmission Glutamate Secretion, Neurotransmission Regulation Of ERK1 And ERK2 Cascade Mast Cell Proliferation Negative Regulation Of Mast Cell Proliferation Leukocyte Apoptotic Process Stem Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Myeloid Leukocyte Migration Observational Learning Regulation Of Postsynapse Organization Negative Regulation Of Schwann Cell Migration Regulation Of Long-term Synaptic Potentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Leukocyte Apoptotic Process Negative Regulation Of Stem Cell Proliferation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Folding Regulation Of Cellular Response To Heat
Pathways		Regulation of RAS by GAPs RAS signaling downstream of NF1 loss-of-function variants	Regulation of HSF1-mediated heat shock response
Drugs
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Adventurousness ( 30643258) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Bitter alcoholic beverage consumption ( 31046077) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Familial squamous cell lung carcinoma ( 29924316) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Haemorrhoidal disease ( 33888516) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 34021172) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Oily fish consumption ( 32066663) Platelet count ( 32888494) Plateletcrit ( 32888494) Pork consumption ( 32066663) Total cholesterol levels ( 29083408) Type 2 diabetes ( 32499647 30297969)	Major depressive disorder x sex interaction ( 34099189)
Interacting Genes		18 interacting genes: AKT1 APP CLK1 CRYBA1 DNAJC7 EFS EPHA2 GRIN1 GRIN2D HRAS HTR6 LIMK2 MAP2K3 RAF1 SDC2 SOX4 TBPL1 VCP	17 interacting genes: BTG3 DISC1 HSP90AA1 HUS1 LCOR MKNK1 NF1 OGT PGR RAD1 RAD9A RSPH1 SMAD2 SMAD9 SMURF1 TP53 UBE4B
Entrez ID		4763	7266
HPRD ID		01203	07046
Ensembl ID		ENSG00000196712	ENSG00000168259
Uniprot IDs		P21359	Q99615
PDB IDs		1NF1 2D4Q 2E2X 3P7Z 3PEG 3PG7 6OB2 6OB3 6V65 6V6F 7MOC 7MP5 7MP6 7PGP 7PGQ 7PGR 7PGS 7PGT 7PGU 7R03 7R04 8E20 8EDL 8EDM 8EDN 8EDO
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Positive Regulation Of Signal Transduction Regulation Of Neuronal Synaptic Plasticity Glial Cell Development Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Signal Transduction Protein Kinase Activity Regulation Of Intracellular Signal Transduction Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Cellular Response To Oxygen-containing Compound Modulation Of Excitatory Postsynaptic Potential Regulation Of Protein Localization Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Activity Glutamate Binding Protein Serine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Excitatory Postsynaptic Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Regulation Of MAPK Cascade Regulation Of Cell Projection Organization Protein Serine/threonine Kinase Activity Excitatory Chemical Synaptic Transmission Regulation Of Synaptic Plasticity Regulation Of Membrane Potential Positive Regulation Of Protein Localization Response To Radiation Insulin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Projection Assembly Positive Regulation Of Intracellular Signal Transduction Regulation Of Postsynaptic Membrane Potential Nucleotide Binding Schwann Cell Development Cell Development Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Migration Developmental Process Regulation Of Phosphorus Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Peptidyl-serine Phosphorylation	Checkpoint Clamp Complex Intracellular Signal Transduction I-SMAD Binding Cellular Response To Ionizing Radiation Disordered Domain Specific Binding Response To Radiation DNA Damage Checkpoint Signaling Nucleoplasm Histone Deacetylase Binding Signal Transduction Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Neuroblast Proliferation Double-stranded DNA 3'-5' DNA Exonuclease Activity Negative Regulation Of Cell Cycle Nucleus Cellular Response To Radiation SMAD Protein Complex Protein Localization To Organelle Meiotic Cell Cycle Checkpoint Signaling Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Neuroblast Proliferation Cytoplasm Striated Muscle Cell Apoptotic Process Transforming Growth Factor Beta Receptor Binding Regulation Of Neural Precursor Cell Proliferation Neural Precursor Cell Proliferation Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Cell Cycle Process Transforming Growth Factor Beta Receptor Signaling Pathway Response To Salt Stress Muscle Cell Apoptotic Process DNA Replication Checkpoint Signaling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Light Stimulus Apoptotic Signaling Pathway SMAD Protein Signal Transduction Establishment Of Protein Localization To Organelle Regulation Of Cellular Response To Growth Factor Stimulus R-SMAD Binding
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