NDUFS1 and CFC1

		NDUFS1	CFC1
Description		NADH:ubiquinone oxidoreductase core subunit S1	cryptic, EGF-CFC family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane Respiratory Chain Complex I	Extracellular Region Plasma Membrane Cell Surface Membrane Side Of Membrane
	Molecular Function	Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Nodal Binding Activin Receptor Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Mitochondrial Respiratory Chain Complex I Assembly ATP Synthesis Coupled Electron Transport Proton Motive Force-driven Mitochondrial ATP Synthesis Cellular Respiration Proton Transmembrane Transport	Blood Vessel Development Signal Transduction Determination Of Left/right Symmetry Gastrulation Heart Development Anterior/posterior Pattern Specification Nodal Signaling Pathway
Pathways		Respiratory electron transport Complex I biogenesis Mitochondrial protein degradation	Signaling by NODAL Regulation of signaling by NODAL
Drugs		NADH
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome	Conotruncal heart malformations, including: Double-outlet right ventricle; Persistent truncus arteriosus; Conotruncal anomaly face syndrome Heterotaxy; Situs ambiguus
GWAS		Body mass index ( 26426971) Chronotype ( 30696823) Daytime nap ( 33568662) Frontotemporal dementia with GRN mutation ( 29724592) Morning person ( 30696823)
Interacting Genes		7 interacting genes: C1QTNF9 CASP3 CFC1 CFLAR KDM1A MDH2 MDM2	9 interacting genes: CCDC74B ELF4 MSN MZT2B NDUFS1 PFDN6 PLEKHB2 SMPD4 TSN
Entrez ID		4719	55997
HPRD ID		01145	05548
Ensembl ID		ENSG00000023228	ENSG00000136698
Uniprot IDs		E5KRK5 P28331	A0A087WWV2 A0A087WX98 P0CG37
PDB IDs		5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Death-inducing Signaling Complex Death Receptor Binding Response To Ionizing Radiation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To UV Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Gamma Radiation Cellular Response To Alkaloid Response To Steroid Hormone Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Apoptotic Signaling Pathway Response To Antibiotic Heart Development Negative Regulation Of Signal Transduction By P53 Class Mediator Response To Hypoxia Response To Decreased Oxygen Levels Response To Light Stimulus Response To Gamma Radiation Response To Oxygen Levels Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process L-malate Dehydrogenase (NADP+) Activity P53 Binding Cellular Response To Ionizing Radiation Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Apoptotic Signaling Pathway Enzyme Activator Activity Response To Alkaloid Response To Radiation Cellular Response To UV Regulation Of Neuron Projection Development Protease Binding Response To Hydrogen Peroxide Phospholipase A2 Activator Activity Cellular Response To Light Stimulus Response To Toxic Substance Skeletal Myofibril Assembly Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Response To Estradiol Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Cysteine-type Peptidase Activity Response To Glucocorticoid L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Response To Vitamin B1 Response To Water-immersion Restraint Stress
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