NDUFB2 and PFKM

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NDUFB2	PFKM
Description		NADH:ubiquinone oxidoreductase subunit B2	phosphofructokinase, muscle
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I	Nucleus Cytoplasm Cytosol 6-phosphofructokinase Complex Membrane Apical Plasma Membrane Sperm Principal Piece
	Molecular Function	NADH Dehydrogenase (ubiquinone) Activity	Nucleotide Binding Catalytic Activity 6-phosphofructokinase Activity Protein Binding ATP Binding Phosphofructokinase Activity Kinase Activity Transferase Activity Kinase Binding Identical Protein Binding Metal Ion Binding Fructose Binding Fructose-6-phosphate Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport	Glycogen Catabolic Process Fructose 6-phosphate Metabolic Process Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Insulin Secretion Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Carbohydrate Phosphorylation Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis Glycolysis From Storage Polysaccharide Through Glucose-1-phosphate
Pathways		Respiratory electron transport Complex I biogenesis	Glycolysis
Drugs		NADH
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS			Glycated hemoglobin levels ( 34059833) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 32888494) Longevity (90 years and older) ( 25199915) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Pulse pressure ( 30578418) Red blood cell count ( 32888494)
Interacting Genes		6 interacting genes: AGR2 CDC7 LCN2 MEOX2 NDUFB7 PFKM	20 interacting genes: ATP6V0A4 CAV3 CEBPA DLC1 DYNLL1 FHL2 HGS LSM7 MAPK3 NDUFB2 NOS1 PCNA PDGFRL PFKL SFRP2 SFRP4 SIAH1 SUMO2 TEAD4 UBTD1
Entrez ID		4708	5213
HPRD ID		11953	01988
Ensembl ID		ENSG00000090266	ENSG00000152556
Uniprot IDs		A4D1T5 O95178	A0A024R0Y5 A0A0S2Z4I1 A0A2R8Y891 F8VTQ3 P08237
PDB IDs		5XTC 5XTD 5XTH 5XTI	4OMT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Response To Herbicide Positive Regulation Of Metabolic Process Regulation Of Hippocampal Neuron Apoptotic Process Positive Regulation Of Iron Ion Import Across Plasma Membrane Positive Regulation Of Hippocampal Neuron Apoptotic Process Siderophore Transport Cytoplasmic Vesicle Lumen Response To Mycotoxin Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Somite Specification ATP Metabolic Process Energy Derivation By Oxidation Of Organic Compounds 6-phosphofructokinase Activity Fructose-6-phosphate Binding Phosphofructokinase Activity Glycolysis From Storage Polysaccharide Through Glucose-1-phosphate 6-phosphofructokinase Complex Lung Goblet Cell Differentiation Positive Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Endothelial Cell Migration Regulation Of Iron Ion Transport Response To Blue Light Response To Iron(II) Ion Regulation Of Endothelial Tube Morphogenesis Fructose Binding Positive Regulation Of Nuclear Cell Cycle DNA Replication Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of IRE1-mediated Unfolded Protein Response Cellular Response To X-ray Response To Fructose Dystroglycan Binding Purine Ribonucleotide Metabolic Process Short-term Memory Cellular Response To Increased Oxygen Levels Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Double-strand Break Repair Via Break-induced Replication Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Generation Of Precursor Metabolites And Energy Fructose 6-phosphate Metabolic Process Cellular Response To Interleukin-6 Segment Specification Somite Development Positive Regulation Of DNA-templated DNA Replication	Caveola Regulation Of Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Heart Trabecula Formation Negative Regulation Of Signaling Negative Regulation Of Transport Negative Regulation Of Cell Communication Negative Regulation Of Potassium Ion Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Z Disc Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cell Development Myoblast Fusion Regulation Of Cell Communication Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hematopoietic Stem Cell Proliferation Response To Hormone Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Canonical Wnt Signaling Pathway Wnt-protein Binding Ubiquitin-like Protein Ligase Binding Protein-containing Complex Binding Cellular Developmental Process Sodium Channel Regulator Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Membrane Repolarization T-tubule Cardiac Muscle Cell Development Regulation Of Sodium Ion Transmembrane Transport Regulation Of Nerve Growth Factor Receptor Activity Regulation Of Proteolysis Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Signal Transduction Negative Regulation Of Sarcomere Organization Cell-cell Fusion Regulation Of Signal Transduction By Receptor Internalization Cardiac Cell Development Syncytium Formation Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Cell Population Proliferation Regulation Of Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Response To Dexamethasone Positive Regulation Of Macromolecule Biosynthetic Process PCNA Complex
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