MYL6 and ADAMTS12

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MYL6	ADAMTS12
Description		myosin light chain 6	ADAM metallopeptidase with thrombospondin type 1 motif 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Brush Border Membrane Myosin Complex Myosin II Complex Unconventional Myosin Complex Vesicle Extracellular Exosome	Extracellular Region Extracellular Matrix
	Molecular Function	Microfilament Motor Activity Cytoskeletal Motor Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Muscle Contraction Skeletal Muscle Tissue Development Muscle Filament Sliding	Ossification Chondrocyte Differentiation Proteoglycan Metabolic Process Proteolysis Cell-matrix Adhesion Cell Migration Proteoglycan Catabolic Process Extracellular Matrix Organization Collagen Fibril Organization Negative Regulation Of Chondrocyte Differentiation Ossification Involved In Bone Maturation Regulation Of Inflammatory Response Proteolysis Involved In Protein Catabolic Process Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To BMP Stimulus Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Cellular Response To Hepatocyte Growth Factor Stimulus
Pathways		EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Asthma ( 31619474)	Blond vs. brown/black hair color ( 30531825) Height ( 31217584) Metabolite levels ( 23823483) Mortality in heart failure ( 20400778) Neurofibrillary tangles ( 31497858) Seasonality and depression ( 30217971) Stroke (pediatric) ( 22990015)
Interacting Genes		12 interacting genes: ADAMTS12 CEBPA CYP27B1 DNAJB9 EWSR1 FNDC3B GLP1R GSK3B HMGB2 MLH1 MOB4 NUDT21	7 interacting genes: CALM2 COIL IHO1 MEOX2 MYL6 TP53BP2 TRIM14
Entrez ID		4637	81792
HPRD ID		17618	05862
Ensembl ID		ENSG00000092841	ENSG00000151388
Uniprot IDs		P60660	D6REX0 P58397
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Peptide Response To Cytokine Positive Regulation Of Developmental Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Cell Differentiation Response To Hormone Regulation Of Cell Differentiation Regulation Of Developmental Process Calcidiol 1-monooxygenase Activity Secalciferol 1-monooxygenase Activity Glucagon-like Peptide 1 Receptor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Condensed Chromosome Somatic Cell DNA Recombination Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Positive Regulation Of Pro-B Cell Differentiation Negative Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Response To Hepatocyte Growth Factor Stimulus Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Immunoglobulin Production Positive Regulation Of Gene Expression Response To Vitamin Response To Vitamin B2 C/EBP Complex Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Apoptotic Signaling Pathway Non-sequence-specific DNA Binding, Bending Regulation Of Immunoglobulin Production Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Stem Cell Differentiation Regulation Of Multicellular Organismal Process Regulation Of Stem Cell Proliferation Response To Lipid CHOP-C/EBP Complex Cellular Response To Tumor Necrosis Factor Vitamin D Biosynthetic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Catabolic Process Glucagon Receptor Activity Negative Regulation Of Signal Transduction Male Meiosis Chromosome Segregation
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