GADD45B and NFIX

		GADD45B	NFIX
Description		growth arrest and DNA damage inducible beta	nuclear factor I X
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Chromatin Nucleus
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Apoptotic Process Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of P38MAPK Cascade	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways			RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS			Bipolar disorder ( 28115744) Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Clozapine-induced agranulocytosis ( 25187353) Cortical surface area ( 32963231) Cortical volume ( 32963231) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Hip index ( 34021172) Intelligence (MTAG) ( 29326435) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		17 interacting genes: CCNB1 CDK1 CDKN1A CFTR CNOT9 EFHC1 ESR1 GADD45G GADD45GIP1 MAP2K7 MAP3K4 MAP3K5 NFIX PCNA PPARA PPARD PPARG	32 interacting genes: ARL4A GADD45B GZMA JMJD6 LHX4 MATK MLLT1 NFIB NRTN PAX2 PAX6 PAX7 PAX8 PIR POLR2E PRDM1 QRICH1 RFX1 RWDD1 SKI SOX10 SOX15 SOX17 SOX5 SOX6 SOX9 SP7 TBR1 TLX2 TLX3 YY1 ZNF614
Entrez ID		4616	4784
HPRD ID		05382	01234
Ensembl ID		ENSG00000099860	ENSG00000008441
Uniprot IDs		O75293	B4DHW2 D2DXM9 Q14938
PDB IDs			7QQD 7QQE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of MiRNA Transcription Positive Regulation Of Metabolic Process Negative Regulation Of Cholesterol Storage Nuclear Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Cyclin B1-CDK1 Complex PCNA-p21 Complex Regulation Of MiRNA Transcription Nuclear Steroid Receptor Activity Negative Regulation Of Lipid Storage Response To Wounding Regulation Of MiRNA Metabolic Process Positive Regulation Of P38MAPK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Rhythmic Process Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Response To Lipid Positive Regulation Of DNA Metabolic Process Positive Regulation Of Fatty Acid Metabolic Process Fibroblast Proliferation Positive Regulation Of DNA Replication Regulation Of P38MAPK Cascade Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Growth Cyclin-dependent Protein Kinase Holoenzyme Complex Hormone-mediated Signaling Pathway Placenta Development Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Biosynthetic Process Regulation Of Lipid Storage Cellular Developmental Process Response To UV Intracellular Signal Transduction Transcription Coactivator Binding Positive Regulation Of RNA Metabolic Process Reproductive Process Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Apoptotic Process Cellular Senescence Enzyme Binding Regulation Of Gene Expression Regulation Of Heart Growth Negative Regulation Of Macromolecule Metabolic Process	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Metanephric Nephron Tubule Formation Regulation Of Gene Expression Cell Fate Commitment Gene Expression Regulation Of Macromolecule Biosynthetic Process Glial Cell Differentiation Negative Regulation Of Developmental Process Metanephric Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Macromolecule Metabolic Process Lacrimal Gland Development Developmental Process Glial Cell Fate Specification Ureter Development Regulation Of Developmental Process Regulation Of Cell Differentiation Neuron Differentiation Positive Regulation Of Macromolecule Metabolic Process Retina Development In Camera-type Eye Regulation Of Stem Cell Differentiation Pattern Specification Process Regionalization
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