KPRP and BTC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KPRP	BTC
Description		keratinocyte proline rich protein	betacellulin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	Protein Binding	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	Desmosome Organization Inflammatory Response Epidermis Development Skin Development Establishment Of Skin Barrier	Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Urine Volume ERBB2-EGFR Signaling Pathway ERBB4-ERBB4 Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Division Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process
Pathways		Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Asthma ( 31619474) Psoriasis ( 25854761)	Breast size ( 27182965) Chronic obstructive pulmonary disease ( 30804561 33909500) Diverticular disease ( 30177863) Electroencephalogram traits ( 25387704) FEV1 ( 30804560) Haemorrhoidal disease ( 33888516) Lung function (FEV1/FVC) ( 30804560)
Interacting Genes		110 interacting genes: ACTMAP AKAP8L ANKS1A ATG9A BTC CATSPER1 CCDC57 CES1 CKS1B CLCNKA CNFN CNNM3 COL8A1 CREB5 CYSRT1 DARS1-AS1 DMRT3 DYRK1A EIF3E ESR2 FAM221B FAM72B FBXO17 FCHO1 FHL2 FHL3 FRS3 GNE GRAP2 GRB2 GUCD1 HCK HEXIM2 HNRNPF HOXA1 HOXC8 HSD3B7 ITGB4 ITIH6 KRTAP1-3 KRTAP1-5 KRTAP10-8 KRTAP12-3 KRTAP13-2 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP3-2 KRTAP4-2 KRTAP4-5 KRTAP5-3 KRTAP5-7 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-3 LCE3A LCE3C LCE3D LCE3E LIMS1 LMO2 LNX1 MAPKBP1 MEOX2 MGAT5B MIIP MLH1 NBPF19 NCK2 NID2 NOTCH2NLA NPBWR2 NR4A3 NTN4 NUFIP2 OTX1 PDGFRB PHLDA1 PLA2G10 PLSCR4 POU4F2 PPIL1 RANBP3 RBP3 RGL2 RNF38 SAXO4 SEMA3B SH3KBP1 SLC15A2 SPRED2 SPRY1 SPRY3 STK16 TEKT4 TFAP2D TNS2 TRIM42 TRIP6 UBASH3A UBASH3B VGLL3 VWC2 ZNF587	11 interacting genes: DNAJC5 EGFR ERBB2 ERBB4 GMPPA KPRP KRT31 KRTAP1-3 MMP9 SGTA SGTB
Entrez ID		448834	685
HPRD ID		18838	02643
Ensembl ID		ENSG00000203786	ENSG00000174808
Uniprot IDs		Q5T749	A0A0S2Z3I5 A0A0S2Z437 P35070
PDB IDs			1IOX 1IP0 8U4J 8U4K
Enriched GO Terms of Interacting Partners?		Intermediate Filament Protein Binding Keratin Filament Keratinization	ERBB2 Signaling Pathway TRC Complex Epidermal Growth Factor Receptor Activity Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor ERBB2-ERBB4 Signaling Pathway Basal Plasma Membrane Localization Within Membrane ERBB2-EGFR Signaling Pathway Positive Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation ERBB Signaling Pathway Neuromuscular Junction ERBB4 Signaling Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Response To UV-A Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Modification Process Protein Tyrosine Kinase Activity Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Epidermis Development Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Programmed Cell Death Protein Targeting To ER Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Establishment Of Protein Localization To Endoplasmic Reticulum Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Establishment Of Protein Localization To Membrane Basolateral Plasma Membrane Receptor Localization To Synapse Positive Regulation Of Growth Peptidyl-tyrosine Phosphorylation Regulation Of Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Multivesicular Body, Internal Vesicle Lumen Protein Localization To Synapse Establishment Of Planar Polarity Involved In Nephron Morphogenesis Structural Constituent Of Skin Epidermis Regulation Of ERK1 And ERK2 Cascade Protein Insertion Into Membrane
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