ASNS and WDR27

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ASNS	WDR27
Description		asparagine synthetase (glutamine-hydrolyzing)	WD repeat domain 27
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleoplasm
	Molecular Function	Nucleotide Binding Asparagine Synthase (glutamine-hydrolyzing) Activity Protein Binding ATP Binding Ligase Activity	Protein Binding
	Biological Process	Asparagine Biosynthetic Process Amino Acid Biosynthetic Process Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Positive Regulation Of Mitotic Cell Cycle L-asparagine Biosynthetic Process
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Aspartate and asparagine metabolism Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs		Aspartic acid Glutamic acid ATP Asparagine
Diseases
GWAS		Regular attendance at a religious group ( 29970889) Tuberculosis ( 30713548)	Carotid intima media thickness x smoking interaction ( 32117412) Eye morphology ( 29921221) Hallux valgus ( 32131869) Insomnia ( 27992416) Insomnia complaints ( 28604731) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Type 1 diabetes ( 21980299)
Interacting Genes		7 interacting genes: ATXN1 CEBPA RAB8A STRN4 SUMO2 TRIM69 WDR27	1 interacting genes: ASNS
Entrez ID		440	253769
HPRD ID		00153	11352
Ensembl ID		ENSG00000070669	ENSG00000184465
Uniprot IDs		P08243	A0A3B3ITF5 A2RRH5
PDB IDs		6GQ3 8SUE 9B6C
Enriched GO Terms of Interacting Partners?		Postsynapse Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Nuclear Matrix Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Vitamin B2 Memory C/EBP Complex Positive Regulation Of Proteasomal Protein Catabolic Process Golgi Vesicle Fusion To Target Membrane Glutamatergic Synapse GABA-ergic Synapse White Fat Cell Proliferation POZ Domain Binding	Asparagine Synthase (glutamine-hydrolyzing) Activity Asparagine Biosynthetic Process L-asparagine Biosynthetic Process L-asparagine Metabolic Process Asparagine Metabolic Process Aspartate Family Amino Acid Metabolic Process Cellular Response To Glucose Starvation Amino Acid Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Ligase Activity Amide Biosynthetic Process L-amino Acid Metabolic Process Alpha-amino Acid Metabolic Process Cellular Response To Starvation Response To Starvation Amino Acid Metabolic Process Carboxylic Acid Biosynthetic Process Cellular Response To Nutrient Levels Positive Regulation Of Cell Cycle
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