MPL and ANKRA2

Number of citations of the paper that reports this interaction (PubMedID 22649097)
0

Data Source:
BioGRID (unspecified method)

		MPL	ANKRA2
Description		MPL proto-oncogene, thrombopoietin receptor	ankyrin repeat family A member 2
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Nuclear Membrane Neuronal Cell Body	Nucleus Cytoplasm Cytosol Cytoskeleton Membrane Protein-containing Complex 3M Complex
	Molecular Function	Cytokine Receptor Activity Protein Binding Thrombopoietin Receptor Activity	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Neutrophil Homeostasis Platelet Formation Monocyte Homeostasis Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Cellular Response To Hypoxia Positive Regulation Of Platelet Formation Eosinophil Homeostasis Basophil Homeostasis	Regulation Of Gene Expression Regulation Of Protein-containing Complex Assembly
Pathways		Platelet Aggregation (Plug Formation)
Drugs		Romiplostim SB-559448 Eltrombopag Thrombopoietin Avatrombopag Lusutrombopag
Diseases		Congenital amegakaryocytic thrombocytopenia (CAMT)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Monobrow thickness ( 26926045)
Interacting Genes		10 interacting genes: ANKRA2 ATXN2L IRS2 JAK2 PTPN11 PTPRF SHC1 SOCS1 THPO YWHAQ	14 interacting genes: ABL1 APP CDKN2A F2RL1 HDAC4 HDAC5 HDAC9 LRP2 MPL NEK6 PDE3B RFX7 SAMD4A TSHZ3
Entrez ID		4352	57763
HPRD ID		01161	12044
Ensembl ID		ENSG00000117400	ENSG00000164331
Uniprot IDs		P40238	Q9H9E1
PDB IDs		8G04	3SO8 3V2O 3V2X 3V31 4LG6 4QQI 8CXG 8CXH 8CXI
Enriched GO Terms of Interacting Partners?		Insulin Receptor Binding Protein Kinase Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Thrombopoietin-mediated Signaling Pathway Myeloid Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptide Hormone Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Phosphatidylinositol 3-kinase Binding Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Cell Activation Cytokine-mediated Signaling Pathway Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Hormone Secretion Megakaryocyte Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Insulin Secretion Neuron Projection Regeneration Hemopoiesis Regulation Of Lymphocyte Activation Positive Regulation Of ERK1 And ERK2 Cascade 14-3-3 Protein Binding Regulation Of Peptide Hormone Secretion Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of D-glucose Import Epithelial Cell Migration Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Lipid Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of D-glucose Transmembrane Transport Phosphotyrosine Residue Binding Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Activation Regulation Of Hormone Secretion Regulation Of Protein Secretion Positive Regulation Of T Cell Activation Signal Transduction Regulation Of MAPK Cascade Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of D-glucose Import Histone H3Y41 Kinase Activity Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway Positive Regulation Of Secretion By Cell	Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone Deacetylase Activity B Cell Differentiation Negative Regulation Of Metabolic Process Protein Kinase C Binding Mononuclear Cell Differentiation Leukocyte Activation Cell Activation Regulation Of Myotube Differentiation Histone Deacetylase Complex Regulation Of Cell Differentiation Leukocyte Differentiation Regulation Of Cell Migration Involved In Sprouting Angiogenesis DNA-binding Transcription Factor Binding Regulation Of Primary Metabolic Process Mitochondrial Depolarization B Cell Activation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Developmental Process Lymphocyte Activation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Type II Interferon Production Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Macromolecule Metabolic Process Lymphocyte Differentiation Negative Regulation Of Long-term Synaptic Potentiation Regulation Of RNA Metabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Striated Muscle Cell Differentiation Epigenetic Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Catecholamine Stimulus Negative Regulation Of Myotube Differentiation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Type II Interferon Production Regulation Of Multicellular Organismal Process Response To Catecholamine Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Superoxide Anion Generation SUMO Transferase Activity Regulation Of Metabolic Process Regulation Of Superoxide Anion Generation Negative Regulation Of Biosynthetic Process Endosome Lumen Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Gene Expression
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