MMP1 and SERPINA3

Number of citations of the paper that reports this interaction (PubMedID 1311327)
0

Data Source:
HPRD (in vitro, in vivo)

		MMP1	SERPINA3
Description		matrix metallopeptidase 1	serpin family A member 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein-containing Complex Assembly Cellular Response To UV-A	Acute-phase Response Inflammatory Response Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Response To Cytokine
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Basigin interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling	Platelet degranulation Neutrophil degranulation
Drugs		Marimastat CGS-27023 N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Choriocarcinoma
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058)	Blood protein levels ( 30072576) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein levels ( 29403010)
Interacting Genes		17 interacting genes: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11	29 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CFTR CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 HSP90AA1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD
Entrez ID		4312	12
HPRD ID		00384	00120
Ensembl ID		ENSG00000196611	ENSG00000196136
Uniprot IDs		B4DN15 P03956 Q53G95	P01011
PDB IDs		1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C	1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE 9C2T 9D7K
Enriched GO Terms of Interacting Partners?		Extracellular Space Extracellular Region Extracellular Matrix Myeloid Leukocyte Migration Leukocyte Chemotaxis Hyaluronic Acid Binding Granulocyte Migration Cell Chemotaxis Regulation Of Cell Migration Cell Migration Granulocyte Chemotaxis Cytokine Activity Monocyte Chemotaxis Eosinophil Migration Eosinophil Chemotaxis Regulation Of Cell Motility Leukocyte Migration CCR Chemokine Receptor Binding Cell Motility Regulation Of Locomotion CCR2 Chemokine Receptor Binding Animal Organ Morphogenesis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Chemotaxis Chemokine Activity Positive Regulation Of Locomotion Locomotion Cytokine-mediated Signaling Pathway Perineuronal Net Chemokine-mediated Signaling Pathway Regulation Of Cell Morphogenesis Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Regulation Of Anatomical Structure Morphogenesis Homeostatic Process Inflammatory Response Cartilage Development Mononuclear Cell Migration Peptidase Inhibitor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Apoptotic Process Regulation Of Lymphocyte Chemotaxis Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Cell Shape Positive Regulation Of Chemotaxis Central Nervous System Development	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptidase Activity Extracellular Matrix Disassembly Secretory Granule Proteolysis Extracellular Region Endopeptidase Activity Hydrolase Activity Extracellular Matrix Organization Extracellular Structure Organization Extracellular Space Protein Metabolic Process Macromolecule Metabolic Process Extracellular Matrix Protein Maturation Protein Processing Amelogenesis Defense Response To Fungus ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Defense Response To Bacterium Response To Fungus Neutrophil-mediated Killing Of Bacterium Glial Cell Development Angiotensin Maturation Protein-containing Complex Localization Response To Yeast Platelet Alpha Granule Protein Catabolic Process Response To Bacterium Neutrophil Mediated Immunity Protein-folding Chaperone Binding Basolateral Plasma Membrane Amyloid-beta Complex Monoatomic Ion Homeostasis Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Monoatomic Cation Homeostasis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Biofilm Matrix Disassembly Killing By Host Of Symbiont Cells Glycoprotein Catabolic Process Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Positive Regulation Of MAP Kinase Activity Regulation Of Protein Serine/threonine Kinase Activity Myelin Sheath
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