MLLT1 and AFF1

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical)
HPRD (two hybrid, in vitro, in vivo)

		MLLT1	AFF1
Description		MLLT1 super elongation complex subunit	ALF transcription elongation factor 1
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytosol Transcription Elongation Factor Complex	Nucleus Transcription Elongation Factor Complex Super Elongation Complex
	Molecular Function	Chromatin Binding Protein Binding	Protein Binding
	Biological Process	Positive Regulation Of DNA-templated Transcription	Regulation Of Gene Expression
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288)	Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Bulimia nervosa ( 23568457) Diastolic blood pressure ( 28234671) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 28869591 30598549) Hematocrit ( 27863252 32888494 29403010) Hematological and biochemical traits ( 31902109) Hemoglobin ( 32888494 29403010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252 29403010) Mean corpuscular volume ( 32888494 27863252 29403010) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) PR interval ( 32439900) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Systemic lupus erythematosus ( 22291604) Total bilirubin levels ( 29403010) Triglyceride levels ( 32154731 30698716 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 30275531 20686565 20864672 25961943) White blood cell count (basophil) ( 27863252 29403010)
Interacting Genes		14 interacting genes: AFF1 AFF4 ALKBH4 ARID1A BMI1 CBX8 FXR1 H1-5 H3-4 MLLT10 NFIX PAF1 WDR5 YIF1A	10 interacting genes: ARFIP1 H3-4 MLLT1 MLLT3 NT5E SASH1 SIAH1 SIAH2 SMAD9 TBCA
Entrez ID		4298	4299
HPRD ID		15933	08871
Ensembl ID		ENSG00000130382	ENSG00000172493
Uniprot IDs		Q03111	B4DJU9 P51825 Q14C88
PDB IDs		5J9S 6HPW 6HPX 6HPY 6HPZ 6HQ0 6HT0 6HT1 6T1I 6T1J 6T1L 6T1M 6T1N 6T1O 7B0T 7B10 7E74 7E7A 7E7C 7X88 7X8B 7X8F 7X8G 8PJI	2LM0
Enriched GO Terms of Interacting Partners?		Heterochromatin Chromatin Organization Regulation Of Macromolecule Biosynthetic Process Chromatin Remodeling Regulation Of Gene Expression Super Elongation Complex Positive Regulation Of Gene Expression, Epigenetic Ubiquitin-protein Transferase Activator Activity Nucleus Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process PRC1 Complex Regulation Of Metabolic Process Transcription Elongation Factor Complex Nucleosome Organization Positive Regulation Of Macromolecule Metabolic Process PcG Protein Complex Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleosome Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Histone H3Q5ser Reader Activity DNA N6-methyladenine Demethylase Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Euchromatin Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Adaxial/abaxial Pattern Formation Histone H3K4me1 Reader Activity Cleavage Furrow Ingression Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Structural Constituent Of Chromatin Positive Regulation Of Macromolecule Biosynthetic Process RING-like Zinc Finger Domain Binding Rostrocaudal Neural Tube Patterning Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Spermatid Development	Transcription Elongation Factor Complex Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding
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