MAP3K10 and KIF3A

Number of citations of the paper that reports this interaction (PubMedID 9427749)
51

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		MAP3K10	KIF3A
Description		mitogen-activated protein kinase kinase kinase 10	kinesin family member 3A
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Kinesin Complex Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Kinesin II Complex Cell Projection Extracellular Exosome Ciliary Tip Axon Cytoplasm
	Molecular Function	Nucleotide Binding Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Serine Kinase Activity	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Cytoskeletal Protein Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Protein Phosphatase Binding Spectrin Binding Small GTPase Binding Protein-containing Complex Binding
	Biological Process	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Protein Autophosphorylation	Organelle Organization Microtubule-based Movement Anterograde Axonal Transport Centriole-centriole Cohesion Transport Along Microtubule Protein Transport Cell Projection Organization Microtubule Anchoring At Centrosome Cilium Assembly Plus-end-directed Vesicle Transport Along Microtubule Protein Localization To Cell Junction
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Hedgehog 'off' state Intraflagellar transport Activation of SMO Activation of SMO COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
Drugs		Fostamatinib
Diseases
GWAS		Birth weight ( 31043758) Resting heart rate ( 27798624)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31619474 31959851) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 22197932 23042114 25574825 26482879) Atopic march ( 26542096) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Refractive error ( 32231278)
Interacting Genes		32 interacting genes: ABL2 CD47 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS1 HGS HTT KIF17 KIF3A KIF3B KIFAP3 LCOR MAP2K4 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB1 RAC1 RACGAP1 SH3RF1 SMURF1 TUBB YWHAE	21 interacting genes: APP BTG3 DISC1 DSCAM DSCR9 GRB2 HUNK KIF3B KIF3C LIG4 MAP3K10 MAP3K11 MORC3 NEK1 NRIP1 PLEKHA5 PPP1R15A RPGR TRIM14 TULP3 VHL
Entrez ID		4294	11127
HPRD ID		02533	05250
Ensembl ID		ENSG00000130758	ENSG00000131437
Uniprot IDs		Q02779	B4DHG8 E9PES4 J3KPF9 Q05CT3 Q9Y496
PDB IDs		2RF0
Enriched GO Terms of Interacting Partners?		MAPK Cascade Kinesin II Complex Protein Phosphatase Binding Cytoplasm Vesicle-mediated Transport Cytoskeleton-dependent Intracellular Transport Plus-end-directed Vesicle Transport Along Microtubule Regulation Of Signal Transduction Dendrite Cytoplasm Signal Transduction Intracellular Signaling Cassette Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Plus-end-directed Organelle Transport Along Microtubule Cytosol Organelle Transport Along Microtubule Regulation Of Multicellular Organismal Process Transport Along Microtubule Nucleotide Binding Anterograde Dendritic Transport Regulation Of Cell Communication Regulation Of Signaling Endocytosis Extracellular Exosome Protein Kinase Binding Intracellular Protein Localization Cellular Localization Vesicle Transport Along Microtubule Kinesin Complex MAP-kinase Scaffold Activity Membrane Invagination Receptor Localization To Synapse Regulation Of Transport Regulation Of Immune System Process Microtubule Microtubule-based Transport MAP Kinase Activity Positive Regulation Of Cellular Component Organization Vesicle Cytoskeletal Trafficking Postsynapse Dendritic Transport Negative Regulation Of Signal Transduction JNK Cascade Cell Surface Receptor Signaling Pathway Mitotic Spindle Intracellular Transport Regulation Of Vesicle-mediated Transport Plus-end-directed Microtubule Motor Activity Microtubule Binding Microtubule Cytoskeleton Positive Regulation Of Leukocyte Migration	Cilium Kinesin Complex JUN Kinase Kinase Kinase Activity Centrosome Positive Regulation Of JUN Kinase Activity Amyloid-beta Complex Positive Regulation Of Metabolic Process Axon Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Plasma Membrane Bounded Cell Projection Organization Central Nervous System Development Regulation Of JNK Cascade Regulation Of Response To Calcium Ion Transport Along Microtubule Amylin Binding Positive Regulation Of JNK Cascade Ephrin Receptor Binding Positive Regulation Of Toll Signaling Pathway Amyloid Fibril Formation Microtubule-based Process Protein Serine/threonine Kinase Binding Cytoplasm Microtubule-based Movement Positive Regulation Of Axon Extension Guanyl-nucleotide Exchange Factor Adaptor Activity ATP Binding Microtubule Establishment Of Integrated Proviral Latency Positive Regulation Of MAP Kinase Activity Phosphorylation Peptidyl-serine Phosphorylation Protein Serine Kinase Activity Protein Phosphorylation Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Cilium Assembly Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Cilium Organization Ciliary Base Ovarian Follicle Rupture Neuron Recognition Ciliary Tip Molecular Adaptor Activity Intraciliary Transport Cell Projection Organization Cytoskeleton-dependent Intracellular Transport Acetylcholine Receptor Activator Activity PTB Domain Binding
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