MAP3K9 and SH3RF1

Number of citations of the paper that reports this interaction (PubMedID 14504284)
0

Data Source:
HPRD (in vitro)

		MAP3K9	SH3RF1
Description		mitogen-activated protein kinase kinase kinase 9	SH3 domain containing ring finger 1
Image
GO Annotations	Cellular Component	Cytoplasm	Cytoplasm Golgi Apparatus Cytosol Lamellipodium Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity Protein Serine Kinase Activity Molecular Function Activator Activity	MAP-kinase Scaffold Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Apoptotic Process Signal Transduction Positive Regulation Of Apoptotic Process Protein Autophosphorylation	MAPK Cascade Neuron Migration Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Response To Aldosterone Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			RHOV GTPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Drugs		12-(2-hydroxyethyl)-2-(1-methylethoxy)-13,14-dihydronaphtho[2,1-a]pyrrolo[3,4-c]carbazol-5(12H)-one Fostamatinib
Diseases
GWAS		Anthropometric traits (multi-trait analysis) ( 30166351) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309)	Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)
Interacting Genes		3 interacting genes: PIK3CA SH3RF1 SMURF1	69 interacting genes: ACAP1 ADAM15 AKT1 AKT2 ARHGEF15 ATN1 ATXN7L2 CBLB CCDC6 DLGAP4 DMRTB1 DNM2 EAF1 EVL FGD1 FHL2 GGN HERPUD1 KCNJ1 LCP2 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 MTURN NAF1 NCF1 NFKBID NHSL2 NUTM2F ONECUT3 PAK2 PDCD6IP PRAM1 PRB3 PRR20A PRR20B PRR20C PRR20D PRR20E PXN RAC1 RACGAP1 RAD23A RIN1 RNF208 RUNX1T1 SEMA6A SF3A2 SH2D4A SH3BP2 SH3D19 SIAH1 SLC22A5 SOCS7 SORBS2 SUFU SYNPO2L TP53BP2 UBASH3A UBE2D1 UBE2D3 UBE2K UBE2N VPS37C WASL WIPF1 XIRP1
Entrez ID		4293	57630
HPRD ID		15965	15335
Ensembl ID		ENSG00000006432	ENSG00000154447
Uniprot IDs		B4DZC4 G3V347 J3KPI6 P80192 Q8NEB1	Q7Z6J0
PDB IDs		3DTC 4UY9	7NZC 7NZD
Enriched GO Terms of Interacting Partners?		Response To Butyrate Response To Ketone Cellular Response To Hydrostatic Pressure Response To Corticosteroid Lamellipodium Response To Steroid Hormone Positive Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Engulfment Of Target By Autophagosome Autosome Genomic Imprinting Response To Muscle Inactivity Regulation Of Developmental Growth Phosphatidylinositol 3-kinase Complex, Class IB Phosphatidylinositol 3-kinase Complex 1-phosphatidylinositol-4-phosphate 3-kinase Activity Transferase Activity Negative Regulation Of Fibroblast Apoptotic Process 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Positive Regulation Of Cell Projection Organization Response To Hydrostatic Pressure Activin Receptor Binding Ubiquitin Protein Ligase Activity Substrate Localization To Autophagosome Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Regulation Of Proteolysis Cardiac Muscle Cell Contraction Phosphatidylinositol 3-kinase Complex, Class IA 1-phosphatidylinositol-3-kinase Activity Response To Water Response To Inactivity Anoikis MAP-kinase Scaffold Activity Relaxation Of Cardiac Muscle Insulin Receptor Substrate Binding Protein Targeting To Vacuole Involved In Autophagy Ectoderm Development Response To L-leucine Regulation Of Developmental Process I-SMAD Binding Negative Regulation Of Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Binding Relaxation Of Muscle Regulation Of Fibroblast Apoptotic Process Regulation Of Growth Phosphatidylinositol-3-phosphate Biosynthetic Process Vascular Endothelial Growth Factor Signaling Pathway Genomic Imprinting Negative Regulation Of Anoikis	SH3 Domain Binding MAP Kinase Kinase Kinase Activity Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly JUN Kinase Kinase Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Protein Autophosphorylation Ubiquitin Conjugating Enzyme Activity Lamellipodium Negative Regulation Of Membrane Tubulation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Actin Filament-based Process Regulation Of Protein Modification Process Focal Adhesion Ubiquitin-dependent Protein Catabolic Process Protein Serine Kinase Activity Modification-dependent Protein Catabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Proteolysis Involved In Protein Catabolic Process T Cell Receptor Signaling Pathway Ubiquitin-protein Transferase Activity Actin Cytoskeleton Organization Actin Polymerization Or Depolymerization Actomyosin Contractile Ring Assembly JNK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Apoptotic Process Cell Surface Receptor Signaling Pathway Signal Transduction Protein Polymerization Programmed Cell Death Cell Death Positive Regulation Of Protein Phosphorylation Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Protein Phosphorylation Cytoskeleton Organization Positive Regulation Of Phosphorylation Regulation Of Signaling Immune Response-activating Signaling Pathway Regulation Of Cell Communication Protein Modification Process Cytoplasm
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