MLF1 and GBA1

		MLF1	GBA1
Description		myeloid leukemia factor 1	glucosylceramidase beta 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Cilium Ciliary Basal Body Cell Projection Perinuclear Region Of Cytoplasm	Extracellular Space Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Protein Domain Specific Binding	Galactosylceramidase Activity Glucosylceramidase Activity Signaling Receptor Binding Scavenger Receptor Binding Protein Binding Beta-glucosidase Activity Transferase Activity Glycosyltransferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Glucosyltransferase Activity Steryl-beta-glucosidase Activity
	Biological Process	Myeloid Progenitor Cell Differentiation DNA-templated Transcription Regulation Of DNA-templated Transcription Cell Differentiation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle G1/S Phase Transition	Mitophagy Lipid Metabolic Process Sphingolipid Metabolic Process Glucosylceramide Metabolic Process Glucosylceramide Catabolic Process Autophagy Mitochondrion Organization Lysosome Organization Central Nervous System Development Steroid Metabolic Process Cholesterol Metabolic Process Determination Of Adult Lifespan Cellular Response To Starvation Response To PH Negative Regulation Of Macromolecule Metabolic Process Microglia Differentiation Regulation Of Macroautophagy Antigen Processing And Presentation Lipid Storage Cerebellar Purkinje Cell Layer Formation Pyramidal Neuron Differentiation Respiratory Electron Transport Chain Termination Of Signal Transduction Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-6 Production T Cell Differentiation In Thymus Response To Testosterone Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Cell Maturation Brain Morphogenesis Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Nervous System Process Neuromuscular Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Neuron Apoptotic Process Establishment Of Skin Barrier Microglial Cell Proliferation Motor Behavior Cellular Response To Tumor Necrosis Factor Hematopoietic Stem Cell Proliferation Response To Dexamethasone Lymphocyte Migration Response To Thyroid Hormone Skin Epidermis Development Beta-glucoside Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Neuronal Action Potential Autophagosome Organization Positive Regulation Of Type 2 Mitophagy Lysosomal Protein Catabolic Process Regulation Of Lysosomal Protein Catabolic Process
Pathways			Association of TriC/CCT with target proteins during biosynthesis Glycosphingolipid catabolism
Drugs			scyllo-inositol N-acetyl-alpha-D-glucosamine Velaglucerase alfa (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-1-NONYLPIPERIDINE-3,4,5-TRIOL
Diseases			Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Gaucher disease
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Depression ( 29700475) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Major depressive disorder ( 27479909) PR interval ( 32439900) Sporadic neuroblastoma ( 28545128) Systolic blood pressure ( 30224653)
Interacting Genes		14 interacting genes: CENPU CLRN1 COP1 COPS3 DNAJB6 GBA1 GMPS GRIK5 MAGEA11 MEOX2 NRBP1 RARRES1 RNF13 YWHAZ	6 interacting genes: MLF1 NEDD4 OGT PSAP SNCA TRIP12
Entrez ID		4291	2629
HPRD ID		03239	06973
Ensembl ID		ENSG00000178053	ENSG00000177628
Uniprot IDs		A0A0S2Z4A4 A0A0S2Z4U8 A0A140VKD2 A0A494C175 A0A499FJ64 B2RD48 C9JNE5 C9K0D4 P58340 Q2TLE4	A0A068F658 B7Z6S9 P04062
PDB IDs		3UAL 3UBW 6Y8E	1OGS 1Y7V 2F61 2J25 2NSX 2NT0 2NT1 2V3D 2V3E 2V3F 2VT0 2WCG 2WKL 2XWD 2XWE 3GXD 3GXF 3GXI 3GXM 3KE0 3KEH 3RIK 3RIL 5LVX 6MOZ 6Q1N 6Q1P 6Q6K 6Q6L 6Q6N 6T13 6TJJ 6TJK 6TJQ 6TN1 6YTP 6YTR 6YUT 6YV3 6Z39 6Z3I 7NWV 8AWK 8AWR 8AX3 8P3E 8P41 9F9Z 9FA3 9FA6 9FAD 9FAL 9FAY 9FAZ 9FB2 9FDI
Enriched GO Terms of Interacting Partners?			Protein Domain Specific Binding Protein Localization To Lysosome Receptor Internalization Regulation Of Protein Catabolic Process Regulation Of Synapse Organization Regulation Of Autophagy Formation Of Structure Involved In A Symbiotic Process Regulation Of Lipid Metabolic Process Ganglioside GM3 Binding Ganglioside GP1c Binding Lipid Binding Positive Regulation Of Beta-galactosidase Activity Enzyme Activator Activity Ganglioside GM1 Transport To Membrane Ganglioside GM2 Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein Localization To Vacuole Channel Inhibitor Activity Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Heterochromatin Boundary Formation Phospholipid Binding Negative Regulation Of Protein Catabolic Process Lysosomal Transport Phosphothreonine Residue Binding Ganglioside GT1b Binding Ganglioside GM1 Binding Negative Regulation Of Serotonin Uptake Negative Regulation Of Protein-containing Complex Assembly Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Generation Of Precursor Metabolites And Energy Protein O-acetylglucosaminyltransferase Activity Perinuclear Region Of Cytoplasm Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Vacuolar Transport Negative Regulation Of Dopamine Metabolic Process Regulation Of Synapse Assembly Regulation Of Protein Localization To Cell Periphery Regulation Of Serotonin Uptake Cell Cortex Nuclear Receptor-mediated Corticosteroid Signaling Pathway Protein-containing Complex
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