MGST1 and SIGLEC12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MGST1	SIGLEC12
Description		microsomal glutathione S-transferase 1	sialic acid binding Ig like lectin 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Azurophil Granule Membrane	Plasma Membrane Membrane
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Protein Binding Transferase Activity	Protein Binding Carbohydrate Binding Sialic Acid Binding
	Biological Process	Glutathione Transport Cellular Response To Lipid Hydroperoxide Cellular Oxidant Detoxification	Cell Adhesion
Pathways		Glutathione conjugation Aflatoxin activation and detoxification Neutrophil degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Glutathione Glutathione disulfide
Diseases
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 32918910) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (2df test) ( 32918910) Bell's palsy ( 33602968) Colorectal cancer (aspirin and/or NSAID use interaction) ( 25781442) Household income (MTAG) ( 31844048) Metabolite levels ( 23823483) Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699) Mild age-related type 2 diabetes ( 34737425) Visceral fat ( 22589738)
Interacting Genes		8 interacting genes: EGF FXYD3 FZD7 LTC4S NELFB SIGLEC12 TNFRSF10C VIP	18 interacting genes: ACSF2 ADIPOQ ATP5PF CDIPT CLEC4G CMAS CTSA DNAAF3 DNAJC30 IL1RL1 MGST1 PLPP6 PLPPR2 PTCH1 PTPN11 PTPN6 TMPRSS4 YIPF1
Entrez ID		4257	89858
HPRD ID		00705	16195
Ensembl ID		ENSG00000008394	ENSG00000254521
Uniprot IDs		F5H613 P10620	Q96PQ1
PDB IDs
Enriched GO Terms of Interacting Partners?			Regulation Of Neutrophil Activation Phosphate-containing Compound Metabolic Process Dephosphorylation Organophosphate Metabolic Process Negative Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of Adaptive Immune Response Negative Regulation Of Cell-cell Adhesion Negative Regulation Of T Cell Proliferation Neutrophil Activation Involved In Immune Response Brain Development Phosphatidate Phosphatase Activity Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Immune System Process Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Cell Adhesion Platelet Formation Megakaryocyte Development Positive Regulation Of Viral Life Cycle Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Transport Negative Regulation Of T Cell Activation Negative Regulation Of Cytokine Production Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Regulation Of Cell Activation Lipid Modification Cellular Response To Lipid Hydroperoxide Negative Regulation Of Cell Population Proliferation Neural Plate Axis Specification Regulation Of Cholesterol Efflux Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cholesterol Transport Reproductive Structure Development Cytokine-mediated Signaling Pathway Regulation Of T Cell Proliferation Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Cell Activation Negative Regulation Of Lymphocyte Activation Regulation Of Tumor Necrosis Factor Production T Cell Costimulation Regulation Of Cytokine-mediated Signaling Pathway Epididymis Development Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Positive Regulation Of D-glucose Import Positive Regulation Of D-glucose Transmembrane Transport
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