MFNG and DLL1

Number of citations of the paper that reports this interaction (PubMedID 12036964)
0

Data Source:
HPRD (in vivo)

		MFNG	DLL1
Description		MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	delta like canonical Notch ligand 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Golgi Apparatus Membrane	Extracellular Region Plasma Membrane Adherens Junction Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Raft Anchoring Junction
	Molecular Function	Transferase Activity Glycosyltransferase Activity O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Activity Metal Ion Binding	Notch Binding Calcium Ion Binding Protein Binding Tat Protein Binding Receptor Ligand Activity Scaffold Protein Binding
	Biological Process	Blastocyst Formation Marginal Zone B Cell Differentiation Pattern Specification Process Regulation Of Notch Signaling Pathway Positive Regulation Of Notch Signaling Pathway	Cell Fate Determination Somitogenesis Somite Specification Heart Looping Inhibition Of Neuroepithelial Cell Differentiation Marginal Zone B Cell Differentiation Type B Pancreatic Cell Development Cell Communication Notch Signaling Pathway Cell-cell Signaling Determination Of Left/right Symmetry Compartment Pattern Specification Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Astrocyte Development Regulation Of Somitogenesis Spinal Cord Development Cerebellar Molecular Layer Formation Cerebellar Purkinje Cell Layer Structural Organization Hemopoiesis Myeloid Cell Differentiation Cell Differentiation Regulation Of Cell Adhesion Neuron Differentiation Negative Regulation Of Epithelial Cell Differentiation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-10 Production Negative Regulation Of Glial Cell Apoptotic Process Organ Growth Regulation Of Growth Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Lateral Inhibition Skeletal Muscle Tissue Growth Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Tissue Growth Neuron Fate Specification Inner Ear Development Regulation Of Neurogenesis Regulation Of Cell Division Retina Development In Camera-type Eye Retina Morphogenesis In Camera-type Eye Neuroepithelial Cell Differentiation Notch Signaling Pathway Involved In Arterial Endothelial Cell Fate Commitment Left/right Axis Specification Nephron Development Proximal Tubule Development Loop Of Henle Development Clathrin-dependent Endocytosis Energy Homeostasis Endothelial Tip Cell Fate Specification Neuronal Stem Cell Population Maintenance Skin Epidermis Development Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Pre-NOTCH Processing in Golgi	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus MECP2 regulates transcription of neuronal ligands Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Formation of paraxial mesoderm Somitogenesis Nephron development
Drugs
Diseases
GWAS			Interferon alpha levels in systemic lupus erythematosus ( 25338677) Intraocular pressure ( 29785010) Plasma anti-thyroglobulin levels ( 29678681) Type 1 diabetes ( 21980299)
Interacting Genes		4 interacting genes: DLL1 JAG1 NOTCH1 NOTCH2	10 interacting genes: ADAM10 CCN3 CNKSR3 MAGI2 MFNG NOTCH1 NOTCH2 NOTCH3 POFUT1 PSEN1
Entrez ID		4242	28514
HPRD ID		03988	05957
Ensembl ID		ENSG00000100060	ENSG00000198719
Uniprot IDs		O00587	A0A384P5C6 O00548
PDB IDs			4XBM
Enriched GO Terms of Interacting Partners?		Nephron Tubule Development Renal Tubule Development Inhibition Of Neuroepithelial Cell Differentiation Kidney Epithelium Development Notch Signaling Pathway Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Left/right Axis Specification Epithelial Cell Development Pulmonary Valve Morphogenesis Morphogenesis Of An Epithelial Sheet Neuronal Stem Cell Population Maintenance Notch Binding Tube Development Neuroepithelial Cell Differentiation Epithelium Development Cell Fate Determination Positive Regulation Of Notch Signaling Pathway Tube Morphogenesis Negative Regulation Of Epithelial Cell Differentiation Ciliary Body Morphogenesis Heart Valve Morphogenesis Cellular Response To Tumor Cell Morphogenesis Of An Epithelium Heart Looping Distal Tubule Development Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Compartment Pattern Specification Embryonic Heart Tube Morphogenesis Cardiac Septum Morphogenesis Negative Regulation Of Neuron Differentiation Tissue Morphogenesis Axis Specification Loop Of Henle Development Regulation Of Embryonic Development Determination Of Bilateral Symmetry Regulation Of Somitogenesis Determination Of Left/right Symmetry Atrioventricular Node Development Regulation Of Notch Signaling Pathway Epidermal Cell Differentiation Proximal Tubule Development Epithelial Tube Morphogenesis Stem Cell Population Maintenance Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Maintenance Of Cell Number Calcium Ion Binding Marginal Zone B Cell Differentiation Regulation Of Inner Ear Auditory Receptor Cell Differentiation	Notch Signaling Pathway Regulation Of Notch Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Golgi Membrane Angiogenesis Protein Catabolic Process At Postsynapse Cellular Response To Tumor Cell Regulation Of Signal Transduction Pattern Specification Process Positive Regulation Of Notch Signaling Pathway Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Atrioventricular Node Development Glomerular Capillary Formation Heart Looping Embryonic Heart Tube Morphogenesis Forebrain Development Marginal Zone B Cell Differentiation Cell Surface Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryonic Limb Morphogenesis Podocyte Development Tube Morphogenesis Cell Surface Receptor Signaling Pathway Limb Morphogenesis Left/right Axis Specification Epithelial Tube Morphogenesis Amyloid Precursor Protein Catabolic Process Lymphocyte Activation Involved In Immune Response Pulmonary Valve Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Negative Regulation Of Myotube Differentiation Myeloid Leukocyte Activation Epithelial Cell Development Morphogenesis Of An Epithelial Sheet Myeloid Dendritic Cell Differentiation Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Membrane Protein Ectodomain Proteolysis Notch Binding Amyloid Precursor Protein Metabolic Process Leukocyte Activation Involved In Immune Response Regulation Of Muscle Cell Differentiation Cell Activation Involved In Immune Response Renal Tubule Development Anterior/posterior Pattern Specification Myeloid Dendritic Cell Activation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mature B Cell Differentiation Involved In Immune Response
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