MEIS2 and CHRNA7

		MEIS2	CHRNA7
Description		Meis homeobox 2	cholinergic receptor nicotinic alpha 7 subunit
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GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Membrane Plasma Membrane Acetylcholine-gated Channel Complex Membrane Dendrite Cation Channel Complex Neuron Projection Plasma Membrane Raft Synapse Postsynaptic Membrane Postsynapse Neurotransmitter Receptor Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Acetylcholine Receptor Activity Toxic Substance Binding Chloride Channel Regulator Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Regulation Of DNA-templated Transcription Brain Development Positive Regulation Of Cell Population Proliferation Visual Learning Response To Mechanical Stimulus Embryonic Pattern Specification Animal Organ Morphogenesis Pancreas Development Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Positive Regulation Of Cardiac Muscle Myoblast Proliferation	Response To Hypoxia Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Signal Transduction Canonical NF-kappaB Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Learning Or Memory Memory Short-term Memory Positive Regulation Of Cell Population Proliferation Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor Production Monoatomic Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Synapse Organization Cognition Sensory Processing Positive Regulation Of Protein Metabolic Process Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Acetylcholine Receptor Signaling Pathway Dendritic Spine Organization Modulation Of Excitatory Postsynaptic Potential Dendrite Arborization Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid-beta Formation Regulation Of Amyloid Precursor Protein Catabolic Process Response To Amyloid-beta Response To Acetylcholine Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Regulation Of Amyloid Fibril Formation Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential
Pathways			Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Drugs			Choline Nicotine Succinylcholine Butabarbital Butalbital Talbutal Pentobarbital Methadone Secobarbital Metharbital Dextromethorphan Cisatracurium Thiopental Mecamylamine Galantamine Primidone Methylphenobarbital Ethanol Amantadine Phenobarbital Tubocurarine Varenicline Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Acetylcholine Lobeline GTS-21 RPI-78M Epibatidine Cytisine Cannabidiol Encenicline Choline salicylate Medical Cannabis Nabiximols
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Hyperactive-impulsive symptoms ( 18821565) Intraocular pressure ( 24002674) Major depressive disorder ( 27479909) Post bronchodilator FEV1 in COPD ( 26634245) Postprandial triglyceride response ( 32603185) Response to antipsychotic treatment ( 20195266) Restless legs syndrome ( 29029846) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)	Hepatocyte growth factor levels ( 25998175)
Interacting Genes		51 interacting genes: ADRA2C ANTKMT ANXA1 APP ARNT2 BPIFA1 C1orf94 CARTPT CCDC196 CHRNA7 CTAG1A CTAG1B DGCR6 DRD1 FAM136A FAM168A HOXA13 HOXA9 IGFBP6 ITGB3BP KRTAP10-8 KRTAP11-1 KRTAP13-1 KRTAP19-2 KRTAP19-6 KRTAP22-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 MCCD1 NDUFB7 NOTO NUP58 OIP5 OSGIN1 PBX1 POU2AF1 POU6F2 PTK6 RBPMS RUSC1 SCT SPMIP6 SQSTM1 TBX2 TIMM10B TLX1 TRIM25 TRIM42 VGLL1 ZNHIT3	7 interacting genes: ADCY6 APP AQR ATXN1 CFTR MEIS2 PIK3R1
Entrez ID		4212	1139
HPRD ID		03443	00339
Ensembl ID		ENSG00000134138	ENSG00000175344
Uniprot IDs		B3KPD8 B7Z6F6 O14770	P36544
PDB IDs		3K2A 4XRM 5BNG 5EG0	2MAW 5AFH 5AFJ 5AFK 5AFL 5AFM 5AFN 7EKI 7EKP 7EKT 7KOO 7KOQ 7KOX 7RPM 8C9X 8CAU 8CE4 8CI1 8CI2 8F4V 8P1H 8UT1 8UTB 8UZJ 8V80 8V82 8V86 8V88 8V89 8V8A 8V8C 8V8D
Enriched GO Terms of Interacting Partners?		Intermediate Filament Positive Regulation Of Long-term Synaptic Potentiation	Visual Behavior Visual Learning Response To Light Stimulus Associative Learning Cellular Response To Forskolin Response To Radiation Response To Forskolin Response To Catecholamine Cellular Response To Catecholamine Stimulus Learning Insulin Receptor Binding Multicellular Organismal-level Water Homeostasis Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Transport Positive Regulation Of Response To Endoplasmic Reticulum Stress Learning Or Memory Cellular Response To Oxygen-containing Compound Chemical Homeostasis Cognition Positive Regulation Of Establishment Of Protein Localization Cellular Response To CAMP Multicellular Organismal-level Chemical Homeostasis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Adult Locomotory Behavior Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Membrane Potential Regulation Of Protein Transport Positive Regulation Of Protein Localization Response To CAMP Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Myeloid Cell Differentiation Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Positive Regulation Of Tumor Necrosis Factor Production Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Anion Channel Activity Homeostatic Process PTB Domain Binding Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import
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