MEF2D and MEF2A

Number of citations of the paper that reports this interaction (PubMedID 9858528)
49

Data Source:
HPRD (in vitro, in vivo)

		MEF2D	MEF2A
Description		myocyte enhancer factor 2D	myocyte enhancer factor 2A
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Sequence-specific DNA Binding SMAD Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	Apoptotic Process Nervous System Development Adult Heart Development Muscle Organ Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade DNA-templated Transcription Regulation Of DNA-templated Transcription Apoptotic Process Nervous System Development Heart Development Muscle Organ Development Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Mitochondrion Distribution Animal Organ Development Dendrite Morphogenesis Ventricular Cardiac Myofibril Assembly Cardiac Conduction ERK5 Cascade Cellular Response To Calcium Ion
Pathways		Transcriptional activation of mitochondrial biogenesis Myogenesis NGF-stimulated transcription NGF-stimulated transcription Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2	ERK/MAPK targets Myogenesis
Drugs
Diseases
GWAS		A body shape index ( 34021172) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Medication use (antimigraine preparations) ( 31015401) Migraine ( 23793025 27182965 27322543 22683712) Migraine - clinic-based ( 23793025) Monocyte count ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) TPE interval (resting) ( 32386560) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Cervical cancer ( 28806749) Dental caries (decayed and filled deciduous teeth) ( 31533690) Gestational age at birth (maternal effect) ( 28598419) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		25 interacting genes: AKT1 APP ASCL1 CABIN1 CARM1 CASP7 CDK6 COPS5 DNMT3L EP300 EPIC1 FBXO7 HDAC4 HDAC5 MAPK14 MAPK7 MEF2A MEF2C NFATC2 PRKACA PRMT5 SKP2 SNCA SP1 YWHAQ	31 interacting genes: ACTN4 ASCL1 CASP3 CASP7 CDK5 DDB1 DNMT3L EP300 ERBIN GABARAPL2 HAND1 HDAC4 HDAC5 HDAC7 HDAC9 HSF2BP MAPK14 MAPK7 MEF2D MEOX1 MYOD1 MYOG NDUFB9 PHB2 SCAND2P SMAD2 SMAD4 SUMO1 TEAD1 THRA VGLL4
Entrez ID		4209	4205
HPRD ID		02810	02807
Ensembl ID		ENSG00000116604	ENSG00000068305
Uniprot IDs		Q14814	A0A0S2Z417 A0A0S2Z453 A0A0S2Z454 A0A0S2Z4C8 A0A0S2Z4N0 A0A8I5KVQ4 A8K720 Q02078
PDB IDs		7X1N 8C84	1C7U 1EGW 1LEW 3KOV 3MU6 3P57 6BYY 6BZ1 7XUZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Cytosol Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Activation Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Neuron Apoptotic Process Transcription Cis-regulatory Region Binding Cellular Response To Fluid Shear Stress Cellular Response To Metal Ion Intracellular Signaling Cassette Cellular Developmental Process Cellular Response To Oxygen-containing Compound DNA-binding Transcription Factor Binding Regulation Of Apoptotic Process Response To Growth Factor RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of Signal Transduction Positive Regulation Of Gene Expression	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Cellular Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Cell Differentiation Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Myotube Differentiation Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Developmental Process Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Macromolecule Biosynthetic Process Animal Organ Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Protein Lysine Deacetylase Activity Positive Regulation Of Biosynthetic Process Regulation Of Muscle Cell Differentiation DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Heart Development Cell Fate Commitment DNA-binding Transcription Factor Binding Histone Deacetylase Activity Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity Skeletal Muscle Tissue Development Striated Muscle Tissue Development Nucleoplasm Chromatin Striated Muscle Cell Differentiation
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