MDM4 and CBLC

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MDM4	CBLC
Description		MDM4 regulator of p53	Cbl proto-oncogene C
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Repressor Complex	Plasma Membrane Membrane Raft
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding	Phosphotyrosine Residue Binding Ubiquitin-protein Transferase Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Transferase Activity SH3 Domain Binding Receptor Tyrosine Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Ventricular Septum Development Atrial Septum Development Negative Regulation Of Cell Population Proliferation Protein Ubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Population Proliferation Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Protein-containing Complex Organization Negative Regulation Of DNA-templated Transcription Protein Stabilization Regulation Of Cell Cycle Protein-containing Complex Assembly Regulation Of Biological Quality Cellular Response To Hypoxia	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Protein Ubiquitination Regulation Of Signaling Protein Catabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Protein Stabilization Response To Glial Cell Derived Neurotrophic Factor
Pathways		Oxidative Stress Induced Senescence Oncogene Induced Senescence Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Breast cancer ( 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 29058716 27117709) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 23544013) Cognitive performance ( 19734545) Diastolic blood pressure ( 27618452 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fish- and plant-related diet ( 32066663) Glioma ( 28346443) Haemorrhoidal disease ( 33888516) Levodopa wearing off effect (time symptoms uncontrolled) in Parkinson's disease (response to zonisamide) ( 32355309) Non-glioblastoma glioma ( 28346443) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 23535732) Regular attendance at a religious group ( 29970889) Systolic blood pressure ( 27618452) Type 2 diabetes ( 32499647)	Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 24507774) Weight ( 28552196)
Interacting Genes		67 interacting genes: AIRIM AKT1 APP ARF1 ATM BECN1 CAPN7 CASP3 CBLC CD160 CD44 CDK1 CDK4 CDKN2A CDKN2B CHEK1 CHEK2 CSNK1A1 E2F1 EP300 EPHA2 FGFR4 GLIS2 HGF LATS2 LRSAM1 MAGEA1 MAP2K5 MDM2 MKRN3 MNAT1 NAA10 NF2 NRON PELI1 PRKAA1 RAD54B RB1 RNF115 S100B SFN SMAD3 SMAD4 SMARCA2 TOP2A TP53 TP63 TP73 TRIM46 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 UBE3A USP7 VPS26C WDR5 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZCCHC2 ZKSCAN3 ZKSCAN4	55 interacting genes: AKT1 BAP1 BIRC2 CCND2 CDK6 CDKN2B CHFR CKM CRK EGFR EPHA2 ERBB2 FGFR4 FYN GLIS2 GRB2 ITCH LATS2 LYN MAP2K3 MDM4 MYC NACAD NF2 NFIC NSD3 OTUD6A OXA1L RAF1 SH3GL3 SHC1 SNCA SPRY2 SRC STK11 TERT TGFB1I1 TP53 TRAF4 TRIM46 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2I UBE2K UBE2L3 UBE2L6 UBE2R2 USP2 USP21 YES1 ZAP70
Entrez ID		4194	23624
HPRD ID		04082	09765
Ensembl ID		ENSG00000198625	ENSG00000142273
Uniprot IDs		A0A087WTR9 A0A087WUE3 A0A087WZ58 O15151 Q59FS6 Q68DC0	Q9ULV8
PDB IDs		2CR8 2MWY 2N06 2N0U 2N0W 2N14 2VJE 2VJF 2VYR 3DAB 3EQY 3FDO 3FE7 3FEA 3JZO 3JZP 3JZQ 3LBJ 3MQR 3U15 4RXZ 5MNJ 5UML 5VK1 6Q9Q 6Q9S 6Q9U 6Q9W 6Q9Y 6YR5 6YR7 7C3Q 7C3Y 7C44 7EL4 7KJN 7MLA 8HDG 8IA5	3OP0 3VRN 3VRO 3VRP 3VRQ 3VRR
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Negative Regulation Of Signaling Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Negative Regulation Of TORC1 Signaling Protein Ubiquitination Regulation Of Apoptotic Process Regulation Of TORC1 Signaling Protein Modification Process Post-translational Protein Modification Nucleus Regulation Of Protein Localization To Nucleus Protein Modification By Small Protein Conjugation Cellular Response To Stress Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TOR Signaling Signal Transduction TORC1 Signaling Negative Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Regulation Of Mitotic Cell Cycle Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of TOR Signaling Regulation Of Protein Localization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Nutrient Levels Regulation Of Cell Population Proliferation Negative Regulation Of Macromolecule Metabolic Process TOR Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Component Organization Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Cell Cycle Phase Transition Regulation Of Protein Stability Positive Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Macromolecule Catabolic Process Programmed Cell Death Cell Death	Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Metabolic Process Regulation Of Signal Transduction Proteolysis Regulation Of Protein Modification Process ATP Binding Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Protein Tyrosine Kinase Activity Regulation Of MAPK Cascade Nucleotide Binding Response To Growth Factor Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Metabolic Process Protein Kinase Activity Cell Surface Receptor Signaling Pathway Kinase Activity Cytosol Regulation Of Protein Metabolic Process Protein Polyubiquitination Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Macromolecule Catabolic Process Positive Regulation Of Phosphate Metabolic Process Protein Modification By Small Protein Conjugation Ephrin Receptor Binding Positive Regulation Of Phosphorylation Protein Ubiquitination Nucleus Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Primary Metabolic Process
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