MDM2 and PSMC5

Number of citations of the paper that reports this interaction (PubMedID 20479273)
26

Data Source:
BioGRID (pull down)

		MDM2	PSMC5
Description		MDM2 proto-oncogene	proteasome 26S subunit, ATPase 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Nuclear Body Transcription Repressor Complex Endocytic Vesicle Membrane Protein-containing Complex Centriolar Satellite Glutamatergic Synapse	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle Proteasome Regulatory Particle, Base Subcomplex Membrane Inclusion Body Proteasome Accessory Complex Cytoplasmic Vesicle Nuclear Proteasome Complex Cytosolic Proteasome Complex Extracellular Exosome Blood Microparticle
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding 5S RRNA Binding Zinc Ion Binding Transferase Activity Ligase Activity SUMO Transferase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Receptor Serine/threonine Kinase Binding Identical Protein Binding Peroxisome Proliferator Activated Receptor Binding Ribonucleoprotein Complex Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Disordered Domain Specific Binding	Nucleotide Binding Signaling Receptor Binding Protein Binding ATP Binding Transcription Factor Binding ATP Hydrolysis Activity TBP-class Protein Binding Thyrotropin-releasing Hormone Receptor Binding Proteasome-activating Activity General Transcription Initiation Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Blood Vessel Development Blood Vessel Remodeling Regulation Of Heart Rate Heart Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Ventricular Septum Development Atrial Septum Development Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Traversing Start Control Point Of Mitotic Cell Cycle Heart Development Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Toxic Substance Response To Iron Ion Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Protein Processing Negative Regulation Of Neuron Projection Development Protein Ubiquitination Protein Sumoylation DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Destabilization Response To Magnesium Ion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Regulation Of Protein Catabolic Process Response To Cocaine Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein-containing Complex Organization Establishment Of Protein Localization Response To Ether Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Response To Antibiotic Positive Regulation Of Protein Export From Nucleus Response To Steroid Hormone Positive Regulation Of Muscle Cell Differentiation Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Cycle Protein Autoubiquitination Cardiac Septum Morphogenesis Protein-containing Complex Assembly Regulation Of Biological Quality Cellular Response To Hydrogen Peroxide Cellular Response To Antibiotic Cellular Response To Vitamin B1 Cellular Response To Alkaloid Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Hypoxia Cellular Response To Gamma Radiation Cellular Response To UV-C Signal Transduction By P53 Class Mediator Fibroblast Activation Cellular Response To Actinomycin D Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Formaldehyde Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Amyloid Fibril Formation Response To Water-immersion Restraint Stress Negative Regulation Of Apoptotic Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Programmed Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways		AKT phosphorylates targets in the cytosol Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins Trafficking of AMPA receptors Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53 Regulation of RUNX3 expression and activity Signaling by ALK fusions and activated point mutants Degradation of CDH1 NPAS4 regulates expression of target genes	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs		Zinc Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Penile cancer Alveolar rhabdomyosarcoma Choriocarcinoma Osteosarcoma Glioma
GWAS		Pneumoconiosis in silica exposure ( 24986923) Red blood cell count ( 32888494)
Interacting Genes		272 interacting genes: ABL1 ABL2 ADRB2 AKAP5 AKT1 ANKRD17 APEX1 APOB APP AR ARRB1 ARRB2 ATF3 ATF4 ATM ATP2A2 ATRX AURKA BAIAP2L1 BRINP1 BTK BTRC CANX CASP2 CASP3 CCAR1 CCDC3 CCNG1 CDC34 CDKN2A CHEK2 CLSTN1 CLU COPS5 CREBBP CSNK2A1 CSNK2A2 CSNK2B CTBP2 CWC25 DAPK1 DAPK3 DAXX DDX24 DDX42 DHFR DLG4 DNAJB4 DYRK2 EGLN3 EID1 EP300 ESR1 EZR F3 FBXO31 FGFR2 FHL2 FKBP1A FOS FOXO1 FOXO3 FOXP3 G3BP2 GADD45A GCAT GLIS2 GNL3 GORAB GRK2 GSK3B GTF2E2 GYS2 H2BC21 H3-4 HCK HDAC1 HEY1 HIF1A HIPK2 HLA-DMB HMGA2 HMGN1 HNRNPK HSP90B1 IER3 IGF1R IL33 IRF1 IRF2 JMY JUN JUND KAT2B KAT5 KIAA1671 KPNA1 LMO7 MAGEA2 MAGEC2 MAP1LC3A MAP2 MAPKAPK2 MAPT MDM4 MED1 MKRN3 MS4A1 MTBP MYC MYD88 MYDGF NACA NAT10 NCL NDUFS1 NGFR NOLC1 NOTCH1 NPIPB3 NPM1 NR1I2 NR3C1 NRON NUCKS1 NUMB OVOL2 PADI4 PAK6 PBX1 PBXIP1 PDCD1 PDE4D PDIA3 PDLIM7 PDS5A PGAM2 PHF7 PHLDB3 PIAS1 PJA1 PKM PLK1 PML POLE POT1 PPIB PPM1D PPP1R10 PRDM2 PRKN PSMA3 PSMC5 PSMD10 PSMD4 PSME3 PTK2 RAB8A RAD23A RALY RANBP1 RANBP2 RARA RASSF1 RB1 RBBP6 RBM10 RBM38 RESF1 RIDA RLIM RNF10 RNF115 RNF126 RNF8 RPL11 RPL22 RPL26 RPL36A RPL4 RPL5 RPS23 RPS3 RPS5 RRM2B RRP1 RSL1D1 RUVBL2 RYBP RYR2 S100A1 S100A2 S100A4 S100A6 S100B SDHC SESN2 SET SETD7 SETDB1 SHPK SIRT2 SIRT3 SMARCA2 SMARCA4 SMARCE1 SMG7 SNCA SORBS2 SRC SREK1 SRSF11 SUMO1 TAF1 TBP TCAP TFIP11 TOP1 TP53 TP53I3 TP53RK TP73 TPR TPT1 TRAF5 TRIB3 TRIM13 TRIM23 TRIM27 TRIM4 TRIM9 TSG101 UBB UBC UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2H UBE2I UBE2J2 UBE2K UBE2L3 UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2U UBE2Z UBE3A UBQLN4 UBTF USP15 USP2 USP7 VCP VEGFA WRN WT1 XBP1 XIAP XPC YY1AP1 ZNF133 ZNF420	75 interacting genes: AKT1 AZIN2 BACH2 BFSP2 CAMK2A CCDC136 CDC42 CFAP206 EPHA8 ERCC3 ERCC6 ESR1 ESR2 ESRRA ESRRG FOS FXR1 GTF2B HARS1 HNF4G HOMER3 HSPA1A HTT INSIG2 KRT15 KRT27 KRT31 KRT38 KRT40 LAMB1 MDM2 MYO18B NR1H3 NR1I2 NR1I3 NR3C2 OGT PDC PDCL PLEKHO1 PPARD PRKN PSMC3 PSMC4 RAD23A RARA RARB RARG RORA RORB RORC RXRA SCOC SHOC2 SIRPA SKA1 SP1 SSNA1 SUMO2 TAF10 TFIP11 THAP11 THRB TNNI2 TNNI3 TNNT1 TP53 TPM1 TRIP11 UBE3C UBLCP1 USP4 VDR VIM XPC
Entrez ID		4193	5705
HPRD ID		01272	03400
Ensembl ID		ENSG00000135679	ENSG00000087191
Uniprot IDs		A0A0A8KB75 A7UKX7 A7UKX8 A7UKX9 G3XA89 Q00987 Q96DS0	A0A140VJS3 P62195
PDB IDs		1RV1 1T4E 1T4F 1YCR 1Z1M 2AXI 2C6A 2C6B 2F1Y 2FOP 2GV2 2HDP 2LZG 2M86 2MPS 2RUH 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ 3MQS 3TJ2 3TPX 3TU1 3V3B 3VBG 3VZV 3W69 4DIJ 4ERE 4ERF 4HBM 4HFZ 4HG7 4JV7 4JV9 4JVE 4JVR 4JWR 4MDN 4MDQ 4OAS 4OBA 4OCC 4ODE 4ODF 4OGN 4OGT 4OGV 4OQ3 4QO4 4QOC 4UD7 4UE1 4UMN 4WT2 4XXB 4ZFI 4ZGK 4ZYC 4ZYF 4ZYI 5AFG 5C5A 5HMH 5HMI 5HMK 5J7F 5J7G 5LAV 5LAW 5LAY 5LAZ 5LN2 5MNJ 5OAI 5OC8 5SWK 5TRF 5UMM 5VK0 5WTS 5XXK 5Z02 5ZXF 6AAW 6GGN 6H22 6HFA 6I29 6I3S 6IM9 6KZU 6Q96 6Q9H 6Q9L 6Q9O 6SQO 6T2D 6T2E 6T2F 6Y4Q 6YR6 7AD0 7AI0 7AI1 7AYE 7BIR 7BIT 7BIV 7BJ0 7BJ6 7BMG 7KJM 7NA1 7NA2 7NA3 7NA4 7NUS 7QDQ 8AEU 8BGU 8EI9 8EIA 8EIB 8EIC 8F0Z 8F10 8F12 8F13 8GCG 8J81 8P0D 8PWC 9GFC	2KRK 3KW6 5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Modification Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Protein Ubiquitination Regulation Of Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Proteolysis Involved In Protein Catabolic Process Positive Regulation Of RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Catabolic Process DNA Damage Response Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Signal Transduction By P53 Class Mediator Cytosol Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Response To Stress	Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor-mediated Signaling Pathway Nuclear Steroid Receptor Activity Hormone-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Developmental Process Retinoic Acid Receptor Signaling Pathway Developmental Process RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Estrogen Response Element Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Nucleus Response To Lipid Regulation Of RNA Biosynthetic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA Binding Transcription By RNA Polymerase II MRNA Transcription Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Hormone Stimulus Intermediate Filament Organization Positive Regulation Of Proteasomal Protein Catabolic Process
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