MCC and KIF3C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MCC	KIF3C
Description		MCC regulator of Wnt signaling pathway	kinesin family member 3C
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Lamellipodium Cell Projection	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Cilium Ciliary Tip
	Molecular Function	Protein Binding Signaling Receptor Activity	Nucleotide Binding Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity
	Biological Process	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Microtubule-based Movement
Pathways			MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Nicotine dependence symptom count ( 25555482) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172)	Atrial fibrillation ( 29892015 30061737)
Interacting Genes		78 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 KAT5 KEAP1 KIF3C KIFC3 LRRC45 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 STOML2 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792	5 interacting genes: CDC5L DISC1 KIF3A MCC TFIP11
Entrez ID		4163	3797
HPRD ID		01157	04164
Ensembl ID		ENSG00000171444	ENSG00000084731
Uniprot IDs		P23508	A2RU78 O14782
PDB IDs		6MTU 6MTV	3B6V
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Centrosome	Kinesin Complex Spliceosomal Complex RNA Splicing, Via Transesterification Reactions WD40-repeat Domain Binding MRNA Splicing, Via Spliceosome Catalytic Step 2 Spliceosome Wnt Signaling Pathway Plus-end-directed Vesicle Transport Along Microtubule Cilium Assembly Plus-end-directed Organelle Transport Along Microtubule Kinesin II Complex Spliceosomal Complex Disassembly Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Protection From Non-homologous End Joining At Telomere U2-type Post-mRNA Release Spliceosomal Complex Radial Glia-guided Pyramidal Neuron Migration Pyramidal Neuron Migration To Cerebral Cortex Cerebral Cortex Radial Glia-guided Migration Central Region Of Growth Cone DNA Replication Factor A Complex RNA Splicing Prp19 Complex Regulation Of Wnt Signaling Pathway Microtubule Microtubule Anchoring At Centrosome Plasma Membrane Bounded Cell Projection Assembly Protein-containing Complex Binding Cell Projection Assembly Microtubule Anchoring At Microtubule Organizing Center Centriole-centriole Cohesion Cilium Organization Telomere Maintenance In Response To DNA Damage Cell Proliferation In Forebrain Negative Regulation Of Epithelial Cell Migration Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
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