MCAM and ATF7IP

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		MCAM	ATF7IP
Description		melanoma cell adhesion molecule	activating transcription factor 7 interacting protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Nuclear Body
	Molecular Function	Laminin Receptor Activity Protein Binding	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding ATP Hydrolysis Activity
	Biological Process	Angiogenesis Glomerular Filtration Cell Adhesion Anatomical Structure Morphogenesis Positive Regulation Of Cell Migration Vascular Wound Healing	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle	PKMTs methylate histone lysines Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases
GWAS		Plateletcrit ( 32888494)	Breast cancer ( 24143190) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Height ( 31562340 33713608) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Leukocyte telomere length ( 32109421) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate-specific antigen levels ( 23359319) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240 28604728 28604732)
Interacting Genes		7 interacting genes: ADRB2 ATF7IP FYN LGALS3 PACS1 PTK2B SHROOM1	71 interacting genes: A2M ACTB ACTG1 AP1B1 CADM1 CEP250 COL4A2 CREB1 CREBBP CSPG4 DISC1 DMTF1 DNM2 EHMT2 EPG5 FLNB FLT4 GMEB1 GTF2E2 GTF2F1 GTF2H1 HEYL HLA-B HMGB1 HSPG2 KIF13A KRT7 LAMA4 LAMA5 LAMC1 LUC7L2 MACF1 MBD1 MCAM MED4 MRI1 NOMO1 NPR1 PAPPA PAPPA2 PCDH1 PEX6 PIAS3 PKD1 PLEKHB2 POLR2C POLR2D POLR2G PRSS8 PSG3 QRICH1 RPS3A RRBP1 SENP3 SETDB1 SLC12A4 SMAD4 SP1 SPTBN1 SREBF2 STBD1 STRN SUMO2 SUSD1 SVEP1 TRIP12 TTC3 UBE2I ZBTB6 ZNF350 ZNF518A
Entrez ID		4162	55729
HPRD ID		01120	09811
Ensembl ID		ENSG00000076706	ENSG00000171681
Uniprot IDs		P43121	B3KNI7 B3KQF8 Q6VMQ6
PDB IDs		6LYN	2RPQ
Enriched GO Terms of Interacting Partners?		Glutamate Receptor Signaling Pathway Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Postsynaptic Density, Intracellular Component Bone Resorption Positive Regulation Of Excitatory Postsynaptic Potential Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Calcium Ion Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Cellular Response To Amyloid-beta Modulation Of Excitatory Postsynaptic Potential Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Calcium Ion Import Response To Amyloid-beta Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Neurotransmitter Receptor Regulator Activity Cellular Response To Glycine Response To Singlet Oxygen Regulation Of Bone Mineralization Cell Body Positive Regulation Of Cellular Component Organization Multicellular Organismal-level Homeostasis Beta2-adrenergic Receptor Activity Negative Regulation Of Multicellular Organismal Process Modulation Of Chemical Synaptic Transmission Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of B Cell Chemotaxis Lymphocyte Activation Response To Glycine Positive Regulation Of Protein Localization To Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Regulation Of Nervous System Process Regulation Of Ossification Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Leukocyte Activation Protein Tyrosine Kinase Activity Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Negative Regulation Of NK T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Regulation Of Multicellular Organismal Development Regulation Of Cell Shape Transmembrane Transporter Binding Norepinephrine Binding Positive Regulation Of Neuron Projection Development	Transcription By RNA Polymerase II DNA-templated Transcription Morphogenesis Of A Polarized Epithelium Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm DNA-templated Transcription Initiation Basement Membrane Laminin-11 Complex Laminin-10 Complex Lymph Vessel Morphogenesis RNA Polymerase II, Core Complex Nucleobase-containing Compound Biosynthetic Process SUMO Transferase Activity Regulation Of Transepithelial Transport Dense Body Regulation Of Multicellular Organismal Development Nuclear Thyroid Hormone Receptor Binding Presynaptic Cytosol Macromolecule Biosynthetic Process Postsynaptic Cytosol Structural Constituent Of Postsynaptic Actin Cytoskeleton Maintenance Of Blood-brain Barrier Proximal Tubule Development Focal Adhesion DNA-directed RNA Polymerase Complex Golgi To Plasma Membrane Protein Transport Histone H3K9me2 Methyltransferase Activity DNA Methylation-dependent Constitutive Heterochromatin Formation Extracellular Exosome Positive Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Histone H3K9 Methyltransferase Activity Nucleus
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