DDI1 and RALGAPA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DDI1	RALGAPA2
Description		DDI proteasomal shuttling factor 1	Ral GTPase activating protein catalytic subunit alpha 2
Image			No pdb structure
GO Annotations	Cellular Component		Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	GTPase Activator Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Proteolysis Proteasomal Protein Catabolic Process Regulation Of Protein Stability Cellular Response To Hydroxyurea Regulation Of DNA Stability	Ral Protein Signal Transduction Regulation Of Protein Localization Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Exocyst Localization Activation Of GTPase Activity
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Cognitive function ( 24684796) Fruit consumption ( 32066663) Height ( 28552196 31562340)
Interacting Genes		18 interacting genes: ADRM1 CCL28 CYGB DVL2 FAM161B GPANK1 GSK3A KLHL42 MFHAS1 NCCRP1 RALGAPA2 RPP25 SDS TEKT3 TRAF2 UBC UBE2K USP2	2 interacting genes: DDI1 RALGAPB
Entrez ID		414301	57186
HPRD ID		13128	11135
Ensembl ID		ENSG00000170967	ENSG00000188559
Uniprot IDs		Q8WTU0	Q2PPJ7
PDB IDs		3S8I
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Catabolic Process Proteolysis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of JNK Cascade Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of UDP-glucose Catabolic Process TORC2 Complex Disassembly Regulation Of Brood Size Outer Acrosomal Membrane Fatty Acid Peroxidase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor	Ral Protein Signal Transduction Regulation Of DNA Stability Cellular Response To Hydroxyurea Response To Hydroxyurea Activation Of GTPase Activity Aspartic-type Endopeptidase Activity
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