MARK1 and NIBAN1

		MARK1	NIBAN1
Description		microtubule affinity regulating kinase 1	niban apoptosis regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Dendrite Cell Projection Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Phosphatidylserine Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Phosphatidic Acid Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Protein Phosphorylation Cytoskeleton Organization Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Wnt Signaling Pathway Intracellular Signal Transduction Regulation Of Dendrite Development Establishment Of Mitochondrion Localization Regulation Of Postsynapse Assembly	Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Translation Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Bipolar disorder ( 22205951) Breast size ( 27182965) Fat distribution (HIV) ( 21897333)
Interacting Genes		17 interacting genes: CCDC102B CCR6 ESRRG GJA5 INCA1 KCNK2 MAP2 MAP4 MAPT NIBAN1 STK11 TAOK1 TCL1B TFAP2A TGFB2 USH2A YAF2	4 interacting genes: AKT1 FHL2 MARK1 NPM1
Entrez ID		4139	116496
HPRD ID		07353	10725
Ensembl ID		ENSG00000116141	ENSG00000135842
Uniprot IDs		A0A087X0I6 B4DIB3 Q9P0L2 X5D2M4	Q9BZQ8
PDB IDs		2HAK 3OSE 6C9D
Enriched GO Terms of Interacting Partners?		Regulation Of Microtubule-based Process Positive Regulation Of Vesicle Transport Along Microtubule Main Axon Central Nervous System Neuron Development Regulation Of Microtubule-based Movement Neuronal Cell Body Neuron Development Tubulin Binding Regulation Of Organelle Transport Along Microtubule Negative Regulation Of Growth Embryonic Limb Morphogenesis Atrial Septum Morphogenesis Limb Morphogenesis Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Stress-activated MAPK Cascade Generation Of Neurons Microtubule Polymerization Negative Regulation Of Developmental Process Regulation Of Growth Regulation Of Axonogenesis Isotype Switching To IgA Isotypes DN3 Thymocyte Differentiation Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Ventricular Septum Morphogenesis Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Skeletal System Development Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Negative Regulation Of Cell Population Proliferation Axon Negative Regulation Of Cell Growth Regulation Of Cell Growth Regulation Of Microtubule Cytoskeleton Organization Microtubule Cytoskeleton Organization Apical Distal Dendrite Negative Regulation Of Microtubule Polymerization Or Depolymerization Tau Protein Binding Microtubule Associated Complex Microtubule Polymerization Or Depolymerization Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Optic Cup Structural Organization	Regulation Of Endodeoxyribonuclease Activity Response To Rapamycin Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Cell Cycle Phase Transition Osteoblast Differentiation Regulation Of MRNA Stability Import Into Nucleus Negative Regulation Of Metabolic Process Microtubule Cytoskeleton Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Apoptotic Process Postsynapse Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Fatty Acid Beta-oxidation Potassium Channel Activator Activity Positive Regulation Of Cell Cycle Process Regulation Of Protein Ubiquitination Mammalian Oogenesis Stage Response To UV Positive Regulation Of Gene Expression Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Protein Import Into Nucleus Regulation Of Organelle Assembly Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Maintenance Of Protein Location In Mitochondrion Regulation Of Postsynapse Organization TRNA (guanine-N7)-methylation Protein Localization To Nucleus Regulation Of RNA Stability Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process TORC2 Complex Binding Cellular Response To Rapamycin Positive Regulation Of Translation Regulation Of Protein Localization To Nucleus Regulation Of Translational Initiation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Nuclear Transport Nucleocytoplasmic Transport Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of TRNA Methylation Negative Regulation Of Programmed Cell Death Positive Regulation Of Endodeoxyribonuclease Activity Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Localization To Nucleus
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