SMAD9 and PIR

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		SMAD9	PIR
Description		SMAD family member 9	pirin
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol SMAD Protein Complex Heteromeric SMAD Protein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding I-SMAD Binding	Transcription Coregulator Activity Protein Binding Quercetin 2,3-dioxygenase Activity Oxidoreductase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Osteoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Morphogenesis Cell Differentiation BMP Signaling Pathway Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway	Transcription By RNA Polymerase II Digestion Myeloid Cell Differentiation Monocyte Differentiation
Pathways		Signaling by BMP	Digestion
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Heel bone mineral density ( 28869591 30598549) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Spontaneous preterm birth (preterm birth) ( 25599974) Total body bone mineral density ( 29304378)
Interacting Genes		117 interacting genes: ABTB1 ACTB ACVR1 AFF1 AP2A1 ARHGAP9 ARID1B ARNT ASB2 ASH2L BAZ1A BTG2 CAMSAP1 CEP135 CHPF CLPB CPXM2 CSH1 CSH2 CTR9 CXXC5 CYP11A1 DIAPH3 DKK1 DNAJA3 DNAJC7 DST DSTN E4F1 EIF3C EIF3E EIF3F ERVV-1 EVC2 EXPH5 FLI1 FN1 FTL GRN HEY1 HEYL HUWE1 KDM1A KDM6A KMT2D LEMD3 LMO4 LNPEP LRP5 MACO1 MAN1A2 MAN1C1 MAN2B1 MBD1 MCM3AP METAP1 MGAT1 MTMR10 MTMR11 NAGK OTUB1 PABPC4 PAPPA PELP1 PHKA2 PIR PKP2 PLEC PNPLA2 PPARD PPP2R5E PRMT6 PSAP PSMD8 QARS1 RANBP9 RFX1 RMND5A RNF123 RRBP1 RUBCN SECISBP2 SF3B1 SIL1 SKIC3 SMAD2 SMAD3 SMAD4 SMG1 SNRNP70 SPTBN1 STAG1 SVEP1 TBCD TERF1 TINAGL1 TOB1 TRIM29 TRIP12 TWNK UBA6 UBE3A UBQLN1 UBQLN4 UNC45A VCPIP1 VPS8 XAB2 YWHAQ ZEB2 ZNF484 ZNF557 ZNF587 ZNF587B ZNF592 ZNF83 ZSCAN4	4 interacting genes: BCL3 NFIX NFKBIA SMAD9
Entrez ID		4093	8544
HPRD ID		04484	04510
Ensembl ID		ENSG00000120693	ENSG00000087842
Uniprot IDs		O15198	O00625
PDB IDs		6FZT	1J1L 3ACL 4ERO 4EWA 4EWD 4EWE 4GUL 4HLT 5JCT 6H1H 6H1I 6N0J 6N0K
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Ameboidal-type Cell Migration Nucleus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Catabolic Process Regulation Of SMAD Protein Signal Transduction Regulation Of Gene Expression Macromolecule Biosynthetic Process SMAD Protein Complex Protein Metabolic Process Regulation Of RNA Metabolic Process Gastrulation Anterior/posterior Pattern Specification Heteromeric SMAD Protein Complex Nucleoplasm Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process R-SMAD Binding Histone Methyltransferase Complex Proteolysis Activin Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Metal Ion Binding Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process MLL3/4 Complex Endoderm Development Catabolic Process Protein Catabolic Process Regionalization Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Negative Regulation Of Autophagosome Maturation Golgi Apparatus Mannose Trimming Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Regulation Of Organelle Organization Ventricular Septum Morphogenesis	Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Bcl3-Bcl10 Complex Protein Import Into Nucleus Import Into Nucleus Bcl3/NF-kappaB2 Complex Intracellular Signaling Cassette Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Follicular Dendritic Cell Differentiation Positive Regulation Of Biosynthetic Process Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Nucleus Follicular Dendritic Cell Activation I-kappaB/NF-kappaB Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of RNA Biosynthetic Process Nuclear Transport Nucleocytoplasmic Transport Positive Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process SMAD Protein Complex Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Heteromeric SMAD Protein Complex Germinal Center Formation Regulation Of Nucleobase-containing Compound Metabolic Process T-helper 2 Cell Differentiation Negative Regulation Of RNA Metabolic Process Marginal Zone B Cell Differentiation Negative Regulation Of Cytokine Production T-helper 1 Type Immune Response Establishment Of Protein Localization To Organelle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of Macrophage Derived Foam Cell Differentiation Response To UV-C Cellular Response To Cold I-SMAD Binding Intracellular Signal Transduction Negative Regulation Of Protein Import Into Nucleus
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