LYN and GP6

Number of citations of the paper that reports this interaction (PubMedID 1715582)
58

Data Source:
HPRD (in vivo, in vitro)

		LYN	GP6
Description		LYN proto-oncogene, Src family tyrosine kinase	glycoprotein VI platelet
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Adherens Junction Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Crista Endocytic Vesicle Membrane Mitochondrial Membrane Protein-containing Complex Integrin Alpha2-beta1 Complex Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component	Plasma Membrane Cell Surface Membrane Membrane Raft Extracellular Exosome Tetraspanin-enriched Microdomain
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding ATP Binding Kinase Activity Transferase Activity SH3 Domain Binding Enzyme Binding Signaling Receptor Activator Activity Ubiquitin Protein Ligase Binding Gamma-tubulin Binding Glycosphingolipid Binding Transmembrane Transporter Binding Protein-containing Complex Binding Ephrin Receptor Binding Phosphoprotein Binding Scaffold Protein Binding Phosphorylation-dependent Protein Binding Phosphatidylinositol 3-kinase Activator Activity	Transmembrane Signaling Receptor Activity Protein Binding Collagen Binding Signaling Receptor Activity Collagen Receptor Activity Protein Tyrosine Kinase Binding
	Biological Process	DNA Damage Checkpoint Signaling Cell Morphogenesis B Cell Homeostasis Regulation Of Cytokine Production Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Stimulatory C-type Lectin Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Adaptive Immune Response Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Tolerance Induction To Self Antigen Histamine Secretion By Mast Cell Platelet Degranulation Innate Immune Response-activating Signaling Pathway Negative Regulation Of Myeloid Leukocyte Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of B Cell Apoptotic Process Protein Phosphorylation Autophagy Response To Stress Inflammatory Response DNA Damage Response Response To Sterol Depletion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Toxic Substance Response To Hormone Response To Carbohydrate Positive Regulation Of Neuron Projection Development Oligodendrocyte Development Fatty Acid Transport Peptidyl-tyrosine Phosphorylation Hemopoiesis Erythrocyte Differentiation Eosinophil Differentiation Positive Regulation Of Cell Migration Negative Regulation Of B Cell Proliferation Neuron Projection Development T Cell Costimulation Lipopolysaccharide-mediated Signaling Pathway Response To Insulin Regulation Of Mast Cell Activation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Interleukin-5-mediated Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis C-X-C Chemokine Receptor CXCR4 Signaling Pathway B Cell Proliferation Positive Regulation Of Phosphorylation Response To Amino Acid Regulation Of Mast Cell Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Response To Peptide Hormone Innate Immune Response Regulation Of Erythrocyte Differentiation Protein Autophosphorylation Ephrin Receptor Signaling Pathway Response To Axon Injury Regulation Of Inflammatory Response Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Cellular Response To Retinoic Acid Cellular Response To Lipid Regulation Of Monocyte Chemotaxis Regulation Of Platelet Aggregation Dendritic Cell Differentiation Neuroinflammatory Response Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Dendritic Cell Apoptotic Process	Immune Response-regulating Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Blood Coagulation Hemostasis Platelet Activation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Platelet Aggregation Positive Regulation Of Platelet Aggregation
Pathways		GPVI-mediated activation cascade Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Cell surface interactions at the vascular wall FCGR activation PECAM1 interactions Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling EPH-Ephrin signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation Co-stimulation by CD28 Co-inhibition by CTLA4 EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Dectin-2 family CD209 (DC-SIGN) signaling CD22 mediated BCR regulation Cyclin D associated events in G1 Platelet Adhesion to exposed collagen Signaling by Erythropoietin Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Growth hormone receptor signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	GPVI-mediated activation cascade Cell surface interactions at the vascular wall Platelet Adhesion to exposed collagen
Drugs		Dasatinib 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Bosutinib Ponatinib Nintedanib Fostamatinib
Diseases
GWAS		Granulocyte count ( 27863252) Height ( 18391951) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Platelet count ( 32888494) Refractive error ( 32231278) Serum thyroid-stimulating hormone levels ( 24852370) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) White blood cell count ( 29403010 27863252 32888494)	Blood protein levels ( 30072576) Breast cancer and/or colorectal cancer ( 29698419) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory biomarkers (multivariate analysis) ( 33110245) Mean platelet volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Platelet aggregation ( 29185836 20526338) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Venous thromboembolism ( 31420334)
Interacting Genes		136 interacting genes: ACTB ADAM15 AGXT AR ARFGEF1 BANK1 BCAR1 BTK CASP3 CASP7 CASP9 CBL CBLC CD19 CD22 CD36 CD72 CD79A CD79B CDK1 CDK2 CDKN1B CHST15 CLCF1 COASY CREBBP CRH CRKL CSF1R CSF2RA CSF2RB CSF3R CSK CSNK2B CTLA4 DAPP1 DLG4 DOK1 DOK2 DOK3 EGFR EPOR ERBB3 ERBB4 EVL FASLG FCAR FCER1G FCGR2A FCGR2B FOLR1 GAB2 GAB3 GP6 GRIA3 HCLS1 HNRNPK IGHA1 IL1B IL2RB IL7 IL7R INPP5D ITPR1 JAK2 KHDRBS1 KIT KLHL41 LCP2 LIME1 MAP4K1 MAPK3 MATK MET MME MS4A1 MS4A2 MUC1 NDFIP2 NEDD9 NEK7 NMT1 NPHS1 PAG1 PAK2 PDCD4 PDE4A PDE4D PECAM1 PIK3CG PILRB PLCG1 PLCG2 PNMA2 PPP1R15A PPP1R8 PRAM1 PRKCD PRKCQ PRKDC PRRG4 PTK2 PTK2B PTPN6 PTPRC RASA1 RGS16 RPL10 RPS6KB1 RPS6KB2 SGK3 SH2B2 SHC1 SKAP1 SKAP2 SLC4A1 SNCA SOCS1 SPHK1 SPHK2 STAT3 SYK TEC TERF1 TNF TRAT1 TRIM28 TRIM55 TRIM63 TRIP10 TRPA1 TRPV4 TYK2 UBB UHRF2 UNC119	7 interacting genes: CRP FCER1G FCGR2A FCGR3A FYN LYN YES1
Entrez ID		4067	51206
HPRD ID		01301	10406
Ensembl ID		ENSG00000254087	ENSG00000088053
Uniprot IDs		A8K379 B4DQ79 P07948 Q6NUK7	Q9HCN6
PDB IDs		1W1F 1WA7 3A4O 5XY1 6NMW 8WFF	2GI7 5OU7 5OU8 5OU9 7NMU 7R58
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Plasma Membrane Antigen Receptor-mediated Signaling Pathway Regulation Of Programmed Cell Death Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response Regulation Of Apoptotic Process Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Immune Response Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling B Cell Receptor Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Adaptive Immune Response Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Cell Activation Immune Response T Cell Receptor Signaling Pathway Protein Kinase Activity Negative Regulation Of Programmed Cell Death Kinase Activity Phosphorylation Protein Phosphorylation Regulation Of Multicellular Organismal Process B Cell Activation Regulation Of Transport Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Cell Activation Regulation Of MAPK Cascade External Side Of Plasma Membrane Leukocyte Activation Regulation Of Leukocyte Proliferation	Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Effector Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-regulating Signaling Pathway IgG Binding Adaptive Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Immune System Process Regulation Of Immune Response Negative Regulation Of Inflammatory Response To Antigenic Stimulus Immunoglobulin Mediated Immune Response Fc-gamma Receptor III Complex Non-membrane Spanning Protein Tyrosine Kinase Activity B Cell Mediated Immunity T Cell Costimulation Immune Response Ephrin Receptor Signaling Pathway Leukocyte Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Acute Inflammatory Response IgG Receptor Activity Regulation Of Immune System Process Antibody-dependent Cellular Cytotoxicity Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Positive Regulation Of Lymphocyte Activation Positive Regulation Of Multicellular Organismal Process Immune Response-activating Signaling Pathway Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulated Exocytosis Hypersensitivity Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cell Activation Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Inflammatory Response Lymphocyte Mediated Immunity Activation Of Immune Response Positive Regulation Of Immune System Process Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Lymphocyte Activation Acute Inflammatory Response To Antigenic Stimulus Transmembrane Transporter Binding Leukocyte Mediated Immunity Regulation Of Lymphocyte Activation Negative Regulation Of Immune System Process Stimulatory C-type Lectin Receptor Signaling Pathway
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