LUM and TRA2B

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		LUM	TRA2B
Description		lumican	transformer 2 beta homolog
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Fibrillar Collagen Trimer Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Extracellular Exosome	Nucleus Nuclear Inner Membrane Nucleoplasm Spliceosomal Complex Protein-containing Complex
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding Pre-mRNA Binding Identical Protein Binding
	Biological Process	Visual Perception Collagen Fibril Organization Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Response To Growth Factor Response To Aroclor 1254	RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Cerebral Cortex Regionalization Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Cellular Response To Glucose Stimulus Embryonic Brain Development
Pathways		Keratan sulfate biosynthesis Keratan sulfate degradation Integrin cell surface interactions ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs		Copper
Diseases
GWAS		Blood protein levels ( 30072576) Intraocular pressure ( 29617998) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure (alcohol consumption interaction) ( 24376456)	Appendicular lean mass ( 33097823) Height ( 31562340) Menarche (age at onset) ( 21102462 25231870 27182965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		6 interacting genes: ACAN CFTR COL1A2 GNAQ MMP14 TRA2B	109 interacting genes: - CDK6 CLK1 CLK3 EPM2AIP1 HINFP HIPK3 HNRNPA1 IVNS1ABP LUM MAGOHB MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYPOP NGFR NXF1 PCDHB14 PIK3CA RBMX RBMXL2 RBMY1A1 RBMY1F RBMY1J RNPS1 SREK1 SRPK1 SRSF10 SRSF2 SRSF3 SRSF4 SRSF8 SRSF9 TNPO3 U2AF1 USP13 YTHDC1 YWHAG YWHAZ ZRANB2
Entrez ID		4060	6434
HPRD ID		02793	04097
Ensembl ID		ENSG00000139329	ENSG00000136527
Uniprot IDs		A0A384N669 P51884	P62995
PDB IDs			2CQC 2KXN 2RRA 2RRB
Enriched GO Terms of Interacting Partners?		Skeletal System Development Response To Ketone Extracellular Matrix Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Collagen Metabolic Process Protein Heterotrimerization Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Golgi Lumen Extracellular Matrix Structural Constituent Odontogenesis Animal Organ Morphogenesis Positive Regulation Of Anion Channel Activity Collagen Type I Trimer Positive Regulation Of Monoatomic Anion Transport Response To Odorant Positive Regulation Of Enamel Mineralization Response To Genistein Transepithelial Water Transport Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway GDF15-GFRAL Signaling Pathway Response To Hydroxyisoflavone Macropinosome Positive Regulation Of Tooth Mineralization Astrocyte Cell Migration Cerebral Cortex Regionalization Chloride Channel Inhibitor Activity Cellular Response To Oxygen-containing Compound Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Phenylpropanoid Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Phospholipase C-activating Serotonin Receptor Signaling Pathway Amelogenesis Extracellular Structure Organization Fibrillar Collagen Trimer Extracellular Matrix Organization Response To Alcohol Perineuronal Net ATPase-coupled Inorganic Anion Transmembrane Transporter Activity System Development Regulation Of Body Fluid Levels Platelet-derived Growth Factor Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Regulation Of Monoatomic Anion Transport	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Extracellular Vesicle Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Regulation Of Metabolic Process Positive Regulation Of MRNA Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Locomotion Negative Regulation Of Cytokine Production Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Protein Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Developmental Process Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Space Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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