BMAL1 and DHTKD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BMAL1	DHTKD1
Description		basic helix-loop-helix ARNT like 1	dehydrogenase E1 and transketolase domain containing 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm PML Body Chromatoid Body Aryl Hydrocarbon Receptor Complex CLOCK-BMAL Transcription Complex	Mitochondrion Mitochondrial Matrix Oxoadipate Dehydrogenase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coregulator Activity Protein Binding Aryl Hydrocarbon Receptor Binding Sequence-specific DNA Binding Protein Dimerization Activity Hsp90 Protein Binding E-box Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Oxoglutarate Dehydrogenase (succinyl-transferring) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Thiamine Pyrophosphate Binding 2-oxoadipate Dehydrogenase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Circadian Rhythm Negative Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Regulation Of Neurogenesis Regulation Of Insulin Secretion Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Canonical Wnt Signaling Pathway Oxidative Stress-induced Premature Senescence Energy Homeostasis Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Acetylation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Cellular Senescence Positive Regulation Of Skeletal Muscle Cell Differentiation	Hematopoietic Progenitor Cell Differentiation Generation Of Precursor Metabolites And Energy Glycolytic Process
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression Heme signaling NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	OADH complex synthesizes glutaryl-CoA from 2-OA
Drugs
Diseases
GWAS			Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		25 interacting genes: AHR AZIN1 BHLHE40 CLOCK CRY1 CSNK1E DELEC1 DHTKD1 EP300 EPAS1 HIF1A HLF HSP90AA1 KAT2B NPAS2 NPAS4 PER3 RARA RHOA RHOU RXRA SIRT1 TRAPPC12 UBE2I ZMYND12	1 interacting genes: BMAL1
Entrez ID		406	55526
HPRD ID		03973	09917
Ensembl ID		ENSG00000133794	ENSG00000181192
Uniprot IDs		A0A140VKD3 A0A669KBF4 B2RCL8 O00327	Q96HY7
PDB IDs		4H10 8RW6 8RW8	5RVW 5RVX 5RVY 5RVZ 5RW0 5RW1 6SY1 6U3J
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Rhythmic Process Circadian Rhythm Transcription Regulator Complex Chromatin Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity Transcription Coactivator Binding E-box Binding Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Photoperiodism Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Primary Metabolic Process Protein Acetylation Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Response To Light Stimulus Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Circadian Rhythm Peptidyl-lysine Acetylation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Gluconeogenesis Regulation Of Gluconeogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Deacetylase Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Hexose Biosynthetic Process Regulation Of Multicellular Organismal Process Nucleus Positive Regulation Of Metabolic Process Response To Radiation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Entrainment Of Circadian Clock By Photoperiod	Oxidative Stress-induced Premature Senescence Positive Regulation Of Protein Acetylation CLOCK-BMAL Transcription Complex Stress-induced Premature Senescence Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Aryl Hydrocarbon Receptor Binding Regulation Of Type B Pancreatic Cell Development Aryl Hydrocarbon Receptor Complex Positive Regulation Of Skeletal Muscle Cell Differentiation Chromatoid Body Response To Redox State Positive Regulation Of Circadian Rhythm Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Hair Cycle Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Hsp90 Protein Binding Regulation Of Cellular Senescence Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Fat Cell Differentiation E-box Binding Cellular Senescence Circadian Regulation Of Gene Expression Energy Homeostasis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of TOR Signaling Positive Regulation Of Canonical Wnt Signaling Pathway PML Body Regulation Of Circadian Rhythm Regulation Of Fat Cell Differentiation Transcription Coregulator Activity Circadian Rhythm Regulation Of TOR Signaling Regulation Of Cold-induced Thermogenesis Positive Regulation Of Wnt Signaling Pathway Regulation Of Insulin Secretion Protein Dimerization Activity DNA-binding Transcription Factor Binding Regulation Of Peptide Hormone Secretion
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