LMAN1 and MCFD2

Number of citations of the paper that reports this interaction (PubMedID 12717434)
0

Data Source:
HPRD (in vitro, in vivo)

		LMAN1	MCFD2
Description		lectin, mannose binding 1	multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Sarcomere COPII-coated ER To Golgi Transport Vesicle Extracellular Matrix Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus ER To Golgi Transport Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding D-mannose Binding Carbohydrate Binding Metal Ion Binding Unfolded Protein Binding	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Golgi Organization Blood Coagulation Gene Expression Positive Regulation Of Organelle Organization Protein Transport Vesicle-mediated Transport Protein Exit From Endoplasmic Reticulum Early Endosome To Golgi Transport Negative Regulation Of Protein Targeting To Mitochondrion	Gene Expression Protein Transport Vesicle-mediated Transport
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER RHOA GTPase cycle RHOC GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Transport to the Golgi and subsequent modification	COPII-mediated vesicle transport Cargo concentration in the ER Transport to the Golgi and subsequent modification
Drugs		Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa	Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases		Combined deficiency of factors V and VIII (F5F8D)	Combined deficiency of factors V and VIII (F5F8D)
GWAS		Cardiac troponin-I levels ( 31014085) Chronotype ( 27494321) Morning vs. evening chronotype ( 27494321)	Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Mean reticulocyte volume ( 32888494) Response to statin therapy ( 20339536)
Interacting Genes		6 interacting genes: APP CEBPA F8 LINC00632 MCFD2 OGT	11 interacting genes: APP CLCA4 CMTM5 F8 IL1RL1 LMAN1 P2RY6 PNLIPRP1 SCD SLC35A1 SYS1
Entrez ID		3998	90411
HPRD ID		03338	09693
Ensembl ID		ENSG00000074695	ENSG00000180398
Uniprot IDs		P49257	B4DF17 Q8NI22
PDB IDs		3A4U 3LCP 3WHT 3WHU 3WNX 4GKX 4GKY 4YGB 4YGC 4YGD 4YGE 8JP4 8JP5 8JP6 8JP7 8JP8 8JP9 8JPG	2VRG 3A4U 3LCP 3WHT 3WHU 3WNX 4YGB 4YGC 4YGD 4YGE 8JP4 8JP5 8JP6 8JP7 8JP8 8JP9 8JPG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Platelet Alpha Granule Lumen Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Acute-phase Response RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Acute Inflammatory Response Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Chromatin DNA Binding Golgi Lumen Defense Response Acetylcholine Receptor Activator Activity Lipoprotein Particle Notch Signaling Pathway Positive Regulation Of Protein Import Inflammatory Response Response To Vitamin B2 C/EBP Complex PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Memory Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Protein O-acetylglucosaminyltransferase Activity Response To Nutrient Regulation Of Synapse Assembly Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Positive Regulation Of Inflammatory Response Axon Midline Choice Point Recognition	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway COPII-coated ER To Golgi Transport Vesicle G Protein-coupled UDP Receptor Activity Cellular Response To Pyrimidine Ribonucleotide Monounsaturated Fatty Acid Biosynthetic Process Interleukin-33 Binding CMP-N-acetylneuraminate Transmembrane Transporter Activity CMP-N-acetylneuraminate Transmembrane Transport Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Golgi Lumen Platelet Alpha Granule Lumen Regulation Of Type II Interferon Production Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Coagulation Blood Coagulation Hemostasis Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane G Protein-coupled UTP Receptor Activity G Protein-coupled ADP Receptor Activity Chloride Transport Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Fatty Acid Biosynthetic Process Palmitoyl-CoA 9-desaturase Activity Stearoyl-CoA 9-desaturase Activity Interleukin-33 Receptor Activity CMP-N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process Intermediate-density Lipoprotein Particle
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