LIG4 and PSMA6

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		LIG4	PSMA6
Description		DNA ligase 4	proteasome 20S subunit alpha 6
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Condensed Chromosome Nucleus Nucleoplasm DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex	Proteasome Complex P-body Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Proteasome Core Complex Ribosome Cilium Nuclear Matrix Proteasome Core Complex, Alpha-subunit Complex Myofibril Sarcomere Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding AMP Binding Ligase Activity Metal Ion Binding	RNA Binding Endopeptidase Activity Protein Binding Purine Ribonucleoside Triphosphate Binding NF-kappaB Binding
	Biological Process	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Repair Base-excision Repair Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Central Nervous System Development Cell Population Proliferation Response To X-ray Response To Ionizing Radiation Response To Gamma Radiation Neurogenesis T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion Cellular Response To Ionizing Radiation DNA Biosynthetic Process Stem Cell Proliferation Establishment Of Integrated Proviral Latency Double-strand Break Repair Via Classical Nonhomologous End Joining DN2 Thymocyte Differentiation Positive Regulation Of Chromosome Organization	Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Inflammatory Response Proteolysis Involved In Protein Catabolic Process
Pathways		2-LTR circle formation Nonhomologous End-Joining (NHEJ)	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs			(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Irritable bowel syndrome ( 29626450)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Creatine kinase levels ( 29403010) Psoriasis ( 20953189 25903422)
Interacting Genes		103 interacting genes: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATOSA ATP6V0D1 ATR B9D1 BBOF1 CAP1 CLU COL1A2 COMMD1 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C MT-CO1 MT-CO2 MT-CO3 MT-ND1 MT-ND4 MT-ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS1 WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT	34 interacting genes: ALKBH4 BRCA1 BRME1 C19orf47 CADM1 CEBPA ECT2 ERH HSPB1 KRTAP4-2 LIG4 LIMD2 NEDD8 PAXIP1 PLK1 POLR2L PSMA2 PSMA3 PSMA4 PSMA7 PSMC6 RNF170 RTP5 SIRPA SMCO3 TEPSIN TRIM39 TSPYL1 UBC UBD USP4 ZBTB44 ZKSCAN4 ZNF596
Entrez ID		3981	5687
HPRD ID		03500	04171
Ensembl ID		ENSG00000174405	ENSG00000100902
Uniprot IDs		A0A0C4DGV9 A8K8Q4 P49917	A0A140VK44 P60900
PDB IDs		1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP 6BKF 6BKG 7D9K 7D9Y 7LSY 7LT3 7NFC 7NFE 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB	4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSG 6MSH 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ 7AWE 7B12 7LXV 7NAN 7NAO 7NAP 7NAQ 7NHT 7PG9 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7V5G 7V5M 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8BZL 8CVR 8CVS 8CVT 8CXB 8JRI 8JRT 8JTI 8K0G 8QYJ 8QYL 8QYM 8QYN 8QYO 8QYS 8QZ9 8TM3 8TM4 8TM5 8TM6 8UD9 8USB 8USC 8YIX 8YIY 8YIZ 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q 9HMN
Enriched GO Terms of Interacting Partners?		Histone H2AXS139 Kinase Activity Respiratory Electron Transport Chain Electron Transport Chain Aerobic Respiration Aerobic Electron Transport Chain Cellular Respiration Regulation Of Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining ATP Synthesis Coupled Electron Transport Positive Regulation Of Signal Transduction By P53 Class Mediator DNA Repair Generation Of Precursor Metabolites And Energy Macromolecule Metabolic Process V(D)J Recombination Proton Transmembrane Transport Respiratory Chain Complex I DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Protein Localization To Site Of Double-strand Break Energy Derivation By Oxidation Of Organic Compounds Extracellular Exosome Response To Ionizing Radiation DNA Metabolic Process Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Double-strand Break Repair Telomere Maintenance Positive Regulation Of Telomerase Catalytic Core Complex Assembly Cytochrome-c Oxidase Activity Proton Motive Force-driven Mitochondrial ATP Synthesis Positive Regulation Of Chromosome Organization Chromosome Organization Protein Localization To Chromosome Positive Regulation Of DNA Metabolic Process Proton Motive Force-driven ATP Synthesis ATP Metabolic Process NADH Dehydrogenase Complex Assembly Mitochondrial Respiratory Chain Complex I Assembly Response To Radiation DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Repair Positive Regulation Of Telomere Maintenance Regulation Of Protein Metabolic Process RNA Binding NADH Dehydrogenase (ubiquinone) Activity Regulation Of Cellular Response To Heat DNA Recombination	Proteasome Core Complex, Alpha-subunit Complex Proteasome Complex Proteasome Core Complex Modification-dependent Protein Catabolic Process Nucleus Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Mitotic G2 DNA Damage Checkpoint Signaling Proteolysis Regulation Of Cell Cycle G2/M Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Mitotic G2/M Transition Checkpoint Cellular Response To Stress Response To Ionizing Radiation Protein Ubiquitination Macromolecule Catabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Protein Modification By Small Protein Conjugation Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of DNA-templated Transcription Initiation Cellular Response To Lithium Ion Regulation Of Canonical NF-kappaB Signal Transduction Protein Tag Activity Proteasomal Protein Catabolic Process Transcription By RNA Polymerase I Midbody Response To Lithium Ion Regulation Of DNA-templated Transcription Initiation Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Double-strand Break Repair DNA Damage Checkpoint Signaling Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Recombination Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Response To Tumor Necrosis Factor Response To Stress Regulation Of Cell Cycle Phase Transition Identical Protein Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Negative Regulation Of Protein Kinase C Signaling Establishment Of Integrated Proviral Latency
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