FAM221B and LBX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM221B	LBX1
Description		family with sequence similarity 221 member B	ladybird homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process		Heart Looping Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Muscle Organ Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Spinal Cord Motor Neuron Differentiation Cell Differentiation Neuron Fate Commitment Neuron Fate Determination Negative Regulation Of Glutamatergic Neuron Differentiation Glutamatergic Neuron Differentiation
Pathways
Drugs
Diseases
GWAS		Multiple sclerosis ( 31604244)	Adolescent idiopathic scoliosis ( 26211971 30395268 31417091) Metabolite levels ( 23823483) Refractive error ( 32231278) Scoliosis ( 22019779) Severe insulin-resistant type 2 diabetes ( 34737425)
Interacting Genes		14 interacting genes: ANKRD11 CCDC13 CYSRT1 EFHC2 GSC2 KPRP KRT35 KRTAP10-8 KRTAP13-1 LBX1 LCE2C LZTS2 PLSCR2 TRIM50	23 interacting genes: AIPL1 DES EFEMP2 EIF5A FAM221B FAM9B IQGAP1 KANK2 KIF5B KIFC3 KRTAP5-6 KRTAP9-2 MAB21L3 PHF1 PRPF31 QRICH1 RBL2 TBCEL TMEM252 TSSK3 UBTFL1 WNK3 ZNF483
Entrez ID		392307	10660
HPRD ID		16675	09178
Ensembl ID		ENSG00000204930	ENSG00000138136
Uniprot IDs		A6H8Z2	P52954
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Epidermis Development Establishment Of Skin Barrier Skin Epidermis Development Negative Regulation Of Glutamatergic Neuron Differentiation Primary Ureteric Bud Growth
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