LAIR1 and MYH3

		LAIR1	MYH3
Description		leukocyte associated immunoglobulin like receptor 1	myosin heavy chain 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane	Cytoplasm Cytosol Muscle Myosin Complex Myosin Complex Myosin II Complex Myofibril Sarcomere Myosin Filament Contractile Muscle Fiber Extracellular Exosome
	Molecular Function	Protein Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Calmodulin Binding ATP Binding ATP Hydrolysis Activity Myosin Phosphatase Activity Actin Filament Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response-regulating Signaling Pathway	Skeletal Muscle Contraction Muscle Contraction Muscle Organ Development Actin Filament-based Movement Muscle Filament Sliding Embryonic Limb Morphogenesis Sarcomere Organization ATP Metabolic Process Face Morphogenesis
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation	Striated Muscle Contraction
Drugs
Diseases			Distal arthrogryposis (DA)
GWAS			Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Relative hand skill in reading disability ( 24068947)
Interacting Genes		13 interacting genes: APP CENPB CFL2 CNOT3 COL1A1 CSK KIR3DS1 LAIR2 MYH3 PRKCG PTPN11 PTPN6 PTPRH	11 interacting genes: APPL1 CLIP4 DYSF GNG5 LAIR1 LAMTOR5 OPTN PPP1R7 PRKD3 SNAPIN TULP3
Entrez ID		3903	4621
HPRD ID		04292	01172
Ensembl ID		ENSG00000167613	ENSG00000109063
Uniprot IDs		A0A0G2JMI0 A0A0G2JNK8 A0A140T8W3 A8MZ84 D3YTC8 Q6GTX8	P11055 Q5GJ67
PDB IDs		3KGR 3RP1 7F9L 7F9M 7F9N
Enriched GO Terms of Interacting Partners?		Face Morphogenesis T Cell Costimulation Negative Regulation Of Neutrophil Activation Myeloid Cell Development Regulation Of Immune Response Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Dephosphorylation Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Regulation Of ERK1 And ERK2 Cascade Protein Tyrosine Phosphatase Activity Negative Regulation Of Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Activity Insulin Receptor Binding Myeloid Leukocyte Activation Negative Regulation Of T Cell Activation Peptidyl-tyrosine Dephosphorylation Phosphoprotein Phosphatase Activity Platelet Formation Dephosphorylation Megakaryocyte Development Positive Regulation Of Cell Activation Regulation Of Interleukin-6 Production Immune Response-regulating Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Cell Activation Involved In Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Lymphocyte Activation Hemopoiesis Response To Mechanical Stimulus Sarcomere Organization Cell-cell Junction Protein Tyrosine Kinase Binding Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Protein Localization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Immune System Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Leukocyte Activation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Vitamin E	Negative Regulation Of Phagocytosis
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