KMT5A and USP17L2

Number of citations of the paper that reports this interaction (PubMedID 31533987)
44

Data Source:
BioGRID (pull down, enzymatic study)

		KMT5A	USP17L2
Description		lysine methyltransferase 5A	ubiquitin specific peptidase 17 like family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Polytene Chromosome Cytosol	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol
	Molecular Function	Transcription Corepressor Activity Protein Binding Methyltransferase Activity Lysine N-methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Histone H4K20 Methyltransferase Activity Histone H4 Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Mitotic Chromosome Condensation Peptidyl-lysine Monomethylation Replication Fork Processing Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Cell Division Protein Localization To Chromatin Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	MAPK Cascade Proteolysis Apoptotic Process Negative Regulation Of Protein Processing Protein Deubiquitination Regulation Of Cell Migration Regulation Of Protein Stability Negative Regulation Of GTPase Activity Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Defense Response To Virus By Host Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination CAAX-box Protein Processing Negative Regulation Of Protein Targeting To Membrane Regulation Of G2/MI Transition Of Meiotic Cell Cycle Regulation Of Ruffle Assembly Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway
Pathways		Condensation of Prophase Chromosomes PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation Negative Regulation of CDH1 Gene Transcription	Ub-specific processing proteases RAS processing
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) High density lipoprotein cholesterol levels ( 29403010)
Interacting Genes		14 interacting genes: BTRC DTL E2F2 FAM9A H4C1 H4C16 PCNA RNF168 RNF8 TCF7L2 TP53 TWIST1 UBE2I USP17L2	11 interacting genes: BRD4 CDK4 CDK6 ELK1 KLF4 KMT5A LGMN LINC02487 SIRT7 UBC ZBTB7A
Entrez ID		387893	377630
HPRD ID		06254	16844
Ensembl ID		ENSG00000183955	ENSG00000223443
Uniprot IDs		E3VVS3 Q9NQR1	Q6R6M4
PDB IDs		1ZKK 2BQZ 3F9W 3F9X 3F9Y 3F9Z 4IJ8 5HQ2 5T5G 5TEG 5TH7 5V2N 5W1Y 6BOZ 7D1Z 7D20 7XPX
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Negative Regulation Of DNA-templated Transcription Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Chromosome Organization Signal Transduction In Response To DNA Damage Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region DNA Metabolic Process Negative Regulation Of Biosynthetic Process Response To Radiation Regulation Of DNA Repair Chromatin Organization Post-translational Protein Modification Protein K63-linked Ubiquitination Regulation Of DNA Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding DNA Repair Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Site Of Double-strand Break DNA Damage Checkpoint Signaling Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein Localization To Chromosome PML Body CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Regulation Of Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Chromatin Remodeling Lymphocyte Activation Involved In Immune Response Telomere Organization Proteolysis Involved In Protein Catabolic Process Regulation Of Primary Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA Repair Translesion Synthesis Synaptonemal Complex	Regulation Of Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle DNA Damage Response Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle G2/M Phase Transition Cyclin Binding Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Cellular Response To Stress Regulation Of Cell Cycle Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Fibroblast Proliferation Cyclin D2-CDK6 Complex Transcription Cis-regulatory Region Binding RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Chromatin Remodeling Histone H4K8ac Reader Activity Nucleolus Organizer Region Polytene Chromosome Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Positive Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Negative Regulation Of RNA Biosynthetic Process FBXO Family Protein Binding Response To Growth Factor Negative Regulation Of Signal Transduction
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