REP15 and RAB34

Number of citations of the paper that reports this interaction (PubMedID 35871249)
67

Data Source:
BioGRID (two hybrid)

		REP15	RAB34
Description		RAB15 effector protein	RAB34, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Endosome Membrane Membrane Early Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome	Cytoplasm Golgi Apparatus Golgi Stack Centrosome Centriole Cytoskeleton Cilium Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Vesicle Golgi Cisterna Ruffle Membrane Cell Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GTP-dependent Protein Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Receptor Recycling Transferrin Transport	Protein Transport Antigen Processing And Presentation Cell Projection Organization Lysosome Localization Golgi To Plasma Membrane Protein Transport Macropinocytosis Positive Regulation Of Smoothened Signaling Pathway Cilium Assembly Cytosolic Ciliogenesis Protein Localization To Plasma Membrane Phagosome Maturation Phagosome-lysosome Fusion
Pathways			RAB geranylgeranylation
Drugs
Diseases
GWAS			Urate levels in lean individuals ( 25811787)
Interacting Genes		9 interacting genes: ARID3A GNG11 RAB15 RAB34 RAB3A RAB3C RAB3D ZRSR2 ZRSR2P1	9 interacting genes: CA8 RABGAP1L RALA REP15 RILP SMAD1 SMAD2 SMAD4 TGFBR1
Entrez ID		387849	83871
HPRD ID		18804	06701
Ensembl ID		ENSG00000174236	ENSG00000109113
Uniprot IDs		Q6BDI9	B4DNC0 E7ES60 P0DI83 Q96PJ7 Q9BZG1
PDB IDs		8A4A 8A4B 8A4C
Enriched GO Terms of Interacting Partners?		GTP-dependent Protein Binding GTPase Activity Myosin V Binding GTP Binding Regulation Of Exocytosis Positive Regulation Of Regulated Secretory Pathway Exocytosis Pre-mRNA 3'-splice Site Binding U2AF Complex Positive Regulation Of Exocytosis Secretion By Cell Regulation Of Regulated Secretory Pathway Synaptic Vesicle Secretion Vesicle Protein Transport Regulation Of Vesicle-mediated Transport Regulation Of Secretion By Cell Vesicle-mediated Transport Regulation Of Secretion Establishment Of Protein Localization Perinuclear Region Of Cytoplasm Lysosome Localization Positive Regulation Of Secretion By Cell Metal Ion Binding Regulation Of Presynaptic Dense Core Granule Exocytosis Positive Regulation Of Secretion Evoked Neurotransmitter Secretion Hydrolase Activity Nucleotide Binding Intracellular Protein Localization Sensory Perception Of Touch Antigen Processing And Presentation Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Regulation Of Dense Core Granule Exocytosis Zymogen Granule Clathrin-sculpted Glutamate Transport Vesicle Membrane Acrosomal Vesicle Exocytosis Clathrin-sculpted Monoamine Transport Vesicle Membrane Constitutive Secretory Pathway Cytosolic Ciliogenesis Regulation Of Plasma Membrane Repair Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Macropinocytosis Spliceosomal Complex Synaptic Vesicle Maturation Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Maintenance Of Presynaptic Active Zone Structure MRNA Splicing, Via Spliceosome Secretory Vesicle	I-SMAD Binding SMAD Protein Complex Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Homomeric SMAD Protein Complex Activin Receptor Signaling Pathway Activin Responsive Factor Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Fate Commitment Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Trophoblast Cell Migration Response To Transforming Growth Factor Beta Roof Of Mouth Development Ubiquitin Protein Ligase Binding Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Response To Growth Factor Co-SMAD Binding Primary MiRNA Processing Secondary Palate Development Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Cardiac Conduction System Development Pattern Specification Process Ameboidal-type Cell Migration Regulation Of Extracellular Matrix Assembly Anterior/posterior Pattern Specification Response To Cholesterol R-SMAD Binding Positive Regulation Of Extracellular Matrix Organization Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Filopodium Assembly Embryonic Cranial Skeleton Morphogenesis Embryonic Axis Specification Endoderm Development MiRNA Processing Tube Development Neuron Fate Commitment Ventricular Septum Morphogenesis Ureteric Bud Development Transcription Regulator Complex Enzyme-linked Receptor Protein Signaling Pathway Establishment Of Protein Localization In Utero Embryonic Development Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Cell Differentiation
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