SUMO4 and PHGDH

Number of citations of the paper that reports this interaction (PubMedID 16236267)
0

Data Source:
HPRD (in vivo)

		SUMO4	PHGDH
Description		small ubiquitin like modifier 4	phosphoglycerate dehydrogenase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus SUMO Ligase Complex	Cytosol Extracellular Exosome
	Molecular Function	Protein Tag Activity Ubiquitin-like Protein Ligase Binding	Phosphoglycerate Dehydrogenase Activity Protein Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor L-malate Dehydrogenase (NAD+) Activity NAD Binding
	Biological Process	Protein Sumoylation Cellular Response To Oxidative Stress Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of DNA-templated Transcription Regulation Of Protein Localization To Nucleus	Glutamine Metabolic Process Glycine Metabolic Process L-serine Metabolic Process L-serine Biosynthetic Process Threonine Metabolic Process Brain Development Amino Acid Biosynthetic Process Gamma-aminobutyric Acid Metabolic Process Regulation Of Gene Expression Taurine Metabolic Process Spinal Cord Development Glial Cell Development Neural Tube Development Neurogenesis Neuron Projection Development G1 To G0 Transition
Pathways			Serine metabolism
Drugs			NADH
Diseases
GWAS		Dupuytren's disease ( 28886342)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Glycine levels ( 31070104 30837465) Height ( 25282103) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Macular telangiectasia type 2 ( 33654266 28250457) Mean corpuscular hemoglobin ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Metabolite levels ( 23378610) Multiple sclerosis ( 31604244 24076602) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Red blood cell count ( 27863252 32888494) Serum metabolite levels ( 33031748) Severe gingival inflammation ( 28459102) Total cholesterol levels ( 30275531)
Interacting Genes		75 interacting genes: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5F1B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB1 PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RACK1 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1	11 interacting genes: APP CEBPA CHMP2B LINC01554 MAPK6 OGT PIAS4 PJA1 SIRT2 SUMO4 TTN
Entrez ID		387082	26227
HPRD ID		10584	06047
Ensembl ID		ENSG00000177688	ENSG00000092621
Uniprot IDs		Q6EEV6	O43175
PDB IDs			2G76 5N53 5N6C 5NZO 5NZP 5NZQ 5OFM 5OFV 5OFW 6CWA 6PLF 6PLG 6RIH 6RJ2 6RJ3 6RJ5 6RJ6 7CVP 7DKM 7EWH 7VA1
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Protein Folding ATP-dependent Protein Folding Chaperone Unfolded Protein Binding Protein Folding Chaperone Cytoplasm Purine Nucleotide Metabolic Process Cytosol Nucleotide Metabolic Process Ubiquitin Protein Ligase Binding Ribose Phosphate Metabolic Process Regulation Of Apoptotic Process Ficolin-1-rich Granule Lumen Purine-containing Compound Metabolic Process Regulation Of Programmed Cell Death Identical Protein Binding RNA Binding Nucleoside Phosphate Metabolic Process Nicotinamide Nucleotide Metabolic Process Protein Refolding ATP Metabolic Process Secretory Granule Lumen Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Peroxiredoxin Activity Ribonucleotide Metabolic Process Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Cytokine Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Telomerase RNA Localization To Cajal Body Mitochondrion Positive Regulation Of Telomere Maintenance Via Telomerase Oxidoreductase Activity Antioxidant Activity Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Ribonucleoprotein Complex Small Molecule Metabolic Process Generation Of Precursor Metabolites And Energy Response To Peptide Enzyme Binding Regulation Of Telomerase RNA Localization To Cajal Body Peroxidase Activity Nucleus Hydrogen Peroxide Metabolic Process Response To Stress Organophosphate Metabolic Process	Positive Regulation Of Proteolysis Negative Regulation Of RNA Biosynthetic Process Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Regulation Of Protein Catabolic Process Protein-containing Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Negative Regulation Of RNA Metabolic Process Nuclear Membrane Reassembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Localization Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Transferase Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nuclear Membrane Organization Membrane Assembly Negative Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Caloric Restriction Positive Regulation Of Binding Regulation Of DNA Binding Protein Sumoylation Regulation Of Synapse Organization Regulation Of Carbohydrate Catabolic Process Autophagy Acetylcholine Receptor Activator Activity Regulation Of ATP Metabolic Process Cognition Protein-containing Complex Organization Response To Metal Ion Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Developmental Process
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