KRTAP10-3 and INPP5D

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KRTAP10-3	INPP5D
Description		keratin associated protein 10-3	inositol polyphosphate-5-phosphatase D
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Membrane Raft
	Molecular Function		Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Hydrolase Activity Phosphatase Activity SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
	Biological Process		Immune System Process Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Determination Of Adult Lifespan Negative Regulation Of Signal Transduction Immunoglobulin Mediated Immune Response Negative Regulation Of Granulocyte Differentiation Negative Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Apoptotic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Neutrophil Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Phosphatidylinositol Dephosphorylation Regulation Of Immune Response Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway Negative Regulation Of B Cell Activation
Pathways		Keratinization	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Downstream TCR signaling PECAM1 interactions Interleukin receptor SHC signaling Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer's disease (late onset) ( 24162737 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Contrast sensitivity ( 24152035) Crohn's disease ( 23128233 22412388) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Family history of Alzheimer's disease ( 30617256) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Serum alkaline phosphatase levels ( 33547301) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		293 interacting genes: ACY3 ADAMTSL3 ADAMTSL4 ADAMTSL5 AEN ALDH3B1 ALPI ALPP AMMECR1 AP1M1 AQP1 AREG AVPI1 AXIN1 B4GALT7 BAHD1 BCL6B BMP7 BMS1P1 BRME1 BUD31 BYSL C10orf62 C22orf39 CARD9 CARHSP1 CATIP CATSPER1 CBX2 CCDC26 CCER1 CD164 CD300A CD300LG CDK5R1 CERK CHIC2 CHRD CHRNG CLDN2 CLK3 CLK4 COL8A1 CREB5 CST2 CST9L CTNNBIP1 CTRC CXCL16 DAAM2 DDX43 DDX6 DERL2 DHRS1 DHX57 DMRT3 DNAL4 DOCK2 EFNA3 EGFL8 ELOA FAM124B FAM161A FAM27E3 FAM74A4 FAM76B FARS2 FBXL18 FBXW5 FOXB1 FZD9 GABARAPL1 GARIN5B GATA2 GEM GFOD1 GIP GLIDR GLIPR2 GLP1R GLRX3 GNE GNMT GOLGA8EP GPRIN2 GSTP1 GTF3C5 H2AC25 HBG1 HBZ HHEX HNRNPLL HOXA1 HPCAL1 HSBP1 HSD3B7 HSPD1 HYAL2 IGSF8 IL2RG INPP5D IQUB IWS1 JOSD1 KAT5 KCNK1 KIAA0040 KIF9 KLHL38 KLK15 KLK8 KRT83 KRTAP10-1 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP13-1 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 LCE1B LCE2A LCE3C LCE3E LIMS2 LINC00636 LINC01588 LMF2 LMNA LUZP4 LYVE1 MAPKBP1 MEOX2 MOBP MPP3 MRPL40 MXI1 NAA10 NAB2 NAXD NDUFAF3 NECTIN2 NECTIN3 NID2 NLK NOTCH2NLA NPBWR2 NPDC1 NPPB NUBP2 NUDCD3 NUFIP2 OLFM2 OPCML OTX1 P2RY6 PCED1A PCSK5 PDE9A PDIA5 PGAP2 PGAP6 PGLS PIGS PIN1 PKD2 PLSCR1 POLL PPARD PRKAA2 PRKAB2 PRKAG1 PRPF31 PTGDS PTGER3 PTPMT1 PTPRH PVR QPRT R3HDM2 RAB7A RAMP3 RHNO1 RNF175 RPS19BP1 RPS28 RPUSD3 RTN4RL1 SCNM1 SDC3 SDCBP SELENOM SERF2 SHFL SLC15A3 SLC23A1 SLC25A10 SLC25A48 SLC35A2 SLC43A2 SLC6A20 SMCO4 SMCP SMOC1 SNAI1 SNHG11 SPACA9 SPATA3 SPATA8 SPG7 SPINK2 SPRY1 SPRY2 STK16 TBC1D23 TEAD4 TEDC2 THAP10 THAP7 TINAGL1 TLE5 TMEM106C TNFRSF6B TNIP3 TNK2 TNP2 TNS2 TRIM42 TRPV6 TTC23 TXNDC5 TYMSOS TYRO3 UCP2 UNC45A UTP23 VPS11 WFDC10B WIF1 WT1 XCL1 YIPF3 ZBTB24 ZBTB9 ZFYVE21 ZFYVE26 ZMYND10 ZNF101 ZNF124 ZNF136 ZNF138 ZNF155 ZNF165 ZNF20 ZNF202 ZNF23 ZNF250 ZNF26 ZNF264 ZNF266 ZNF32 ZNF417 ZNF433 ZNF439 ZNF446 ZNF461 ZNF490 ZNF559 ZNF564 ZNF572 ZNF578 ZNF581 ZNF587 ZNF625 ZNF670 ZNF679 ZNF688 ZNF697 ZNF699 ZNF763 ZNF786 ZNF79 ZNF792 ZNRF2P1 ZSCAN21 ZSCAN26	48 interacting genes: ARAP1 CD22 CD300LF CEBPA CRK CRKL CSF1R CSF3R CYSRT1 DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR1BP FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP6-3 LILRB4 LYN MET NOTCH2NLA PAX6 PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 SLAMF1 XIAP ZDHHC17
Entrez ID		386682	3635
HPRD ID		11189	09033
Ensembl ID		ENSG00000212935	ENSG00000168918
Uniprot IDs		P60369	Q92835
PDB IDs			2YSX 5RW2 5RW3 5RW4 5RW5 5RW6 5RW7 5RW8 5RW9 5RWA 5RWB 5RWC 5RWD 5RWE 5RWF 5RWG 5RWH 5RWI 5RWJ 5RWK 5RWL 5RWM 5RWN 5RWO 5RWP 5RWQ 5RWR 5RWS 5RWT 5RWU 5RWV 5RWW 5RWX 5RWY 5RWZ 5RX0 5RX1 5RX2 5RX3 5RX4 5RX5 5RX6 5RX7 5RX8 5RX9 5RXA 5RXB 5RXC 5RXD 5RXE 5RXF 5RXG 5RXH 5RXI 5RXJ 5RXK 5RXL 5RXM 5RXO 5RXP 5RXQ 5RXR 5RXS 5RXT 5RXU 5RXV 5RXW 5RXX 5RXY 5RXZ 5RY0 5RY1 5RY2 5RY3 5RY4 5RY5 5RY6 5RY7 5RY8 5RY9 5RYA 5RYB 5RYC 5RYD 5RYE 5RYF 5RYG 5RYH 5RYI 5RYJ 5RYK 5RYL 6IBD 6XY7 8PDG 8PDH 8PDI 8PDJ 8UM5
Enriched GO Terms of Interacting Partners?		Protein Binding Keratin Filament Intermediate Filament RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II DNA Binding Hair Cycle AMP-activated Protein Kinase Activity	Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Immune System Process Negative Regulation Of Immune System Process Regulation Of MAPK Cascade Negative Regulation Of Immune Response Regulation Of Immune Response Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Positive Regulation Of Immune System Process Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Cell Migration Positive Regulation Of MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Multicellular Organismal Process Protein Phosphatase Binding Cell Motility Regulation Of Cell Activation Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Vesicle-mediated Transport Cellular Developmental Process Positive Regulation Of Cell Migration Fc-gamma Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Regulation Of Signal Transduction Positive Regulation Of Locomotion Leukocyte Differentiation Cell Differentiation Negative Regulation Of Leukocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Immune Effector Process Regulation Of Cell Shape Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Lymphocyte Activation Plasma Membrane Negative Regulation Of Cell Activation Regulation Of Cell Population Proliferation
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