KRTAP10-1 and CBX2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KRTAP10-1	CBX2
Description		keratin associated protein 10-1	chromobox 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Euchromatin Heterochromatin Nucleus Nucleoplasm Chromosome PcG Protein Complex PRC1 Complex
	Molecular Function		DNA Binding Chromatin Binding Protein Binding Histone H3K9me2/3 Reader Activity
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Sex Differentiation Cell Differentiation Development Of Primary Sexual Characteristics
Pathways		Keratinization	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases			46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS			Brain morphology (MOSTest) ( 32665545)
Interacting Genes		152 interacting genes: ADAMTSL4 AEN AMMECR1 ATP23 AVPI1 BAHD1 BCL6B C17orf50 C22orf39 CAMK1G CARD9 CATSPER1 CBX2 CHIC2 CHRD CLPP CRCT1 CREB5 CTSZ CXCL16 CYSRT1 DAAM2 DEFB112 DHX57 DKK1 DOCK2 ECE1 FAM76B FBXO34 FCHO1 FUCA2 GLRX3 HOXA1 HOXA9 HPCAL1 HSD3B7 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP13-3 KRTAP2-3 KRTAP2-4 KRTAP21-2 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-1 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LINGO1 MAPKBP1 MEOX2 MOBP MRPL12 NBPF19 NECTIN2 NKD1 NLK NOTCH2NLA NPDC1 NR1D2 NR4A1 NR4A3 NUFIP2 OTX1 PID1 PIN1 PLLP POM121L8P POU4F2 PPARA PRKAG1 PRM2 PRPF31 RNF8 RSPO2 SH3GLB2 SHFL SLC23A1 SLC6A20 SMCP SPATA24 SPATA3 SPATA8 SPRY1 SPRY2 TNP2 TRIM42 TSPAN4 TULP3 WT1 ZBTB24 ZNF101 ZNF124 ZNF138 ZNF264 ZNF286A ZNF329 ZNF417 ZNF433 ZNF438 ZNF439 ZNF440 ZNF559 ZNF572 ZNF581 ZNF587 ZNF625 ZNF664 ZNF768 ZNF785 ZSCAN12 ZSCAN26	25 interacting genes: BOLL CYSRT1 DHX57 H3-3A H3-4 H3C1 H3C14 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-4 KRTAP4-12 KRTAP4-4 MDFI MEOX2 RBMY1A1 RBMY1F RBMY1J RBPMS2 RYBP TRIM55 TRIM63
Entrez ID		386677	84733
HPRD ID		11184	14397
Ensembl ID		ENSG00000215455	ENSG00000173894
Uniprot IDs		P60331	Q14781
PDB IDs			2D9U 3H91 5EPK
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Hair Cycle RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Zinc Ion Binding DNA Binding Lung Growth Identical Protein Binding DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding	Keratin Filament Intermediate Filament Structural Constituent Of Chromatin Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Nucleosome Assembly Regulation Of MRNA Splicing, Via Spliceosome Nucleosome Positive Regulation Of RNA Splicing Nucleosome Organization Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Protein-DNA Complex Assembly Hair Cycle Identical Protein Binding Positive Regulation Of MRNA Metabolic Process Protein Heterodimerization Activity Chromatin Remodeling Spliceosomal Complex
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