KRTAP10-6 and ZC3HAV1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP10-6	ZC3HAV1
Description		keratin associated protein 10-6	zinc finger CCCH-type containing, antiviral 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Nucleus Cytoplasm Lysosome Late Endosome Cytosol
	Molecular Function	Protein Binding	RNA Binding NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Cadherin Binding Metal Ion Binding NAD+ Binding NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process		Immune System Process Response To Virus Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Positive Regulation Of MRNA Catabolic Process Protein Poly-ADP-ribosylation Positive Regulation Of RIG-I Signaling Pathway
Pathways		Keratinization	Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS			Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Multiple sclerosis ( 31604244) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)
Interacting Genes		87 interacting genes: ADAMTSL3 AVPI1 CLK1 CLK4 DHX57 DKK2 FOXD4 HAND1 HHEX HOXB5 KIAA0040 KIF9 KRTAP10-1 KRTAP10-5 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A MOBP MT1B NAA10 NAXD NKD1 NMU NOL12 NPDC1 PBXIP1 PIN1 RSPO2 SLC33A2 SNIP1 SPATA3 STRA6 VASN WT1 YTHDC1 ZBTB24 ZC3HAV1 ZIM2 ZNF114 ZNF138 ZNF155 ZNF169 ZNF221 ZNF239 ZNF264 ZNF280C ZNF302 ZNF319 ZNF418 ZNF440 ZNF479 ZNF490 ZNF543 ZNF563 ZNF595 ZNF600 ZNF669 ZNF672 ZNF679 ZNF696 ZNF774 ZNF776 ZNF792 ZNHIT1	11 interacting genes: AKT1 APP FOXP1 KRTAP10-6 MDFI NXF1 OGT PCBP3 SNRPA SRSF11 USP7
Entrez ID		386674	56829
HPRD ID		11192	09534
Ensembl ID		ENSG00000188155	ENSG00000105939
Uniprot IDs		P60371	C9J6P4 Q7Z2W4
PDB IDs			2X5Y 4X52 6UEI 6UEJ 7KZH 7TGQ 9BGL
Enriched GO Terms of Interacting Partners?		Keratinization Epidermis Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intermediate Filament Tissue Development Zinc Ion Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Regulation Of Transcription By RNA Polymerase II Keratin Filament Hair Cycle Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Wnt Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Metal Ion Binding Diaphragm Development Cartilage Morphogenesis Regulation Of Macromolecule Metabolic Process	TORC1 Signaling TOR Signaling Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of TOR Signaling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Communication Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hemopoiesis Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Phosphatidylinositol-3,4,5-trisphosphate Binding Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Identical Protein Binding Cellular Response To Nerve Growth Factor Stimulus Nucleic Acid Binding Response To Nerve Growth Factor Nucleus Negative Regulation Of Gene Expression Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Cellular Response To Nutrient Levels Regulation Of TRNA Methylation Maintenance Of Protein Location In Cell Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Gluconeogenesis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly
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