KRT6A and GNL1

		KRT6A	GNL1
Description		keratin 6A	G protein nucleolar 1 (putative)
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Extracellular Space Nucleus
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis	Nucleotide Binding GTPase Activity Structural Molecule Activity GTP Binding
	Biological Process	Morphogenesis Of An Epithelium Positive Regulation Of Cell Population Proliferation Cell Differentiation Keratinization Killing Of Cells Of Another Organism Wound Healing Intermediate Filament Organization Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Entry Of Bacterium Into Host Cell	T Cell Mediated Immunity DNA Damage Response Signal Transduction
Pathways		Keratinization Formation of the cornified envelope
Drugs		Zinc Zinc acetate
Diseases		Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS		Cutaneous squamous cell carcinoma ( 32041948)	Autism spectrum disorder or schizophrenia ( 28540026) Lung cancer ( 28604730) Major depressive disorder ( 27479909) Neuroticism ( 29255261) Rosacea symptom severity ( 29771307) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		49 interacting genes: BEX2 CCDC85B CCR1 DSP GEM GNL1 GOLGA2 HGS KDM1A KIFC3 KRT1 KRT13 KRT15 KRT17 KRT18 KRT19 KRT25 KRT26 KRT27 KRT28 KRT3 KRT31 KRT34 KRT35 KRT36 KRT38 KRT4 KRT40 KRT5 KRT6B KRT7 LMNA MTUS2 NCALD NUP62 PRPH RND1 SGTA SMARCB1 TARBP2 TCHP TFIP11 TMBIM6 TRIM23 TRIM54 TSGA10 TXLNB UBQLN2 WASHC3	8 interacting genes: DAXX GDI1 KRT6A PTP4A1 SIRPA VPS35 YIF1A ZNF212
Entrez ID		3853	2794
HPRD ID		01011	00879
Ensembl ID		ENSG00000205420	ENSG00000204590
Uniprot IDs		A0A0S2Z428 P02538	A0A024RCR2 B4DYK6 P36915
PDB IDs		5KI0
Enriched GO Terms of Interacting Partners?		Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Cytoskeleton Organization Epithelial Cell Differentiation Cytoskeleton Organelle Organization Tissue Morphogenesis Morphogenesis Of An Epithelium Structural Constituent Of Cytoskeleton Keratinization Extracellular Exosome Cellular Developmental Process Intermediate Filament Cytoskeleton Cell Differentiation Anatomical Structure Morphogenesis Hair Follicle Morphogenesis Epidermis Development Developmental Process Scaffold Protein Binding Cytosol Hair Cycle Process Protein Binding Adherens Junction Cornified Envelope Tissue Development Epithelial Cell-cell Adhesion Peptide Cross-linking Positive Regulation Of ERAD Pathway	Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Sodium Arsenite Cellular Response To Salt Cellular Response To Diamide Cellular Response To Sodium Arsenite Vesicle-mediated Transport To The Plasma Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Negative Regulation Of Protein Targeting To Membrane Rab GDP-dissociation Inhibitor Activity Negative Regulation Of Entry Of Bacterium Into Host Cell Neuromuscular Process General Adaptation Syndrome, Behavioral Process Positive Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Protein Homooligomerization Mitochondrion-derived Vesicle Positive Regulation Of Wnt Protein Secretion Regulation Of Locomotion Involved In Locomotory Behavior Tubular Endosome Negative Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of Dopamine Metabolic Process Retromer, Cargo-selective Complex Positive Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Biosynthetic Process Voluntary Musculoskeletal Movement Regulation Of Terminal Button Organization Regulation Of Dopamine Biosynthetic Process Mitochondrion To Lysosome Vesicle-mediated Transport Negative Regulation Of Protein Oligomerization Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Protein Binding Involved In Heterotypic Cell-cell Adhesion Cellular Response To Interleukin-12 Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Response To Interleukin-12 Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Monocyte Extravasation Positive Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Entry Of Bacterium Into Host Cell D1 Dopamine Receptor Binding Negative Regulation Of Inflammatory Response Negative Regulation Of Cellular Component Organization Negative Regulation Of Protein Localization Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Protein Antigen Binding Neurotransmitter Receptor Transport To Postsynaptic Membrane Mitochondrial Fragmentation Involved In Apoptotic Process Establishment Of Protein Localization To Postsynaptic Membrane Regulation Of Lysosomal Protein Catabolic Process Regulation Of Dopamine Receptor Signaling Pathway
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